Windows of Susceptibility to PAH/DEP Exposure and Asthma
PAH/DEP 暴露和哮喘的易感性窗口
基本信息
- 批准号:8080991
- 负责人:
- 金额:$ 65.05万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-06-01 至 2012-05-31
- 项目状态:已结题
- 来源:
- 关键词:AcuteAdolescenceAffectAgeAirAir PollutantsAir PollutionAllergicAnimalsAromatic Polycyclic HydrocarbonsAsthmaBackBehavioralBiologicalBiological MarkersBiostatistics CoreBirthCarbon BlackCharacteristicsChildChildhood AsthmaCitiesClinicalClinical ResearchClinical TreatmentCohort StudiesCollectionCotinineDataData SetDevelopmentDiesel ExhaustDiseaseEducationEnrollmentEnsureEnvironmentEnvironmental ExposureEnvironmental HealthEnvironmental Tobacco SmokeEpidemiologic StudiesEpigenetic ProcessEpithelial CellsExhalationExposure toFetusFundingGeneticGrantHumanHypersensitivityIgEImmunoglobulinsIn VitroIndividualInflammatory ResponseIntegration Host FactorsInterventionInvestigationLeadLinkMeasurementMeasuresMetabolicNatural experimentNatureNitric OxideObesityOutcomeOutcome MeasureParticulate MatterPathogenesisPatternPhysiciansPhysiologicalPlasmaPlayPoliciesPositioning AttributePredispositionProxyPublic HealthPublic PolicyQuestionnairesRegulationReportingResearchResearch Project GrantsRespiratory physiologyRiskRisk FactorsRoleSamplingSmooth Muscle MyocytesSourceStagingSulfurSymptomsTechnologyTeenagersThird Pregnancy TrimesterTimeUncertaintyUrineWheezingair cleanerair samplingairway inflammationasthma preventionatopybasecohortdata managementearly childhoodearly life exposurefetalfollow-uphazardimprovedin uteroinner cityinnovationnutritionparticleparticle exposurepollutantpostnatalprenatalpreventprospectiverespiratoryrespiratory smooth muscleresponsesuccesstime intervaltraffickingtrendurinary
项目摘要
This proposal is submitted in response to the RFA-ES-06-001 DISCOVER initiative. The fetus and young
child have physiologic, developmental, metabolic, and behavioral patterns that make them uniquely
vulnerable to hazards in their environments. Ambient air pollution has been implicated as a major risk factor
for asthma and asthma exacerbation, however epidemiological studies have been hampered by
uncertainties in exposures and the nature of airway responses.
The Columbia Center for Children's Environmental Health (CCCEH) Disease Investigation through
Specialized Clinically-Oriented Ventures in Environmental Research (DISCOVER) seeks to understand
when and how airborne polycyclic aromatic hydrocarbons (PAHs) and diesel exhaust particles(DEP)
increase the risk for childhood asthma and airway inflammation, develop new biomarkers to identify children
at risk and improve clinical treatment, evaluate the success of a public policy intervention, and implement
physician education initiatives as a mode of intervention.
This proposal includes four closely linked projects and both an Administartive and Data Management and
Biostatistics Core each ensuring the seamless coordintion of the multiple research acivities involved in this
proposal. The cores play vital roles in the quality of research information and statistical analyses and the
administrative/financial oversight and translational components1 of the fourmain DISCOVER research project
initiatives. The four project aims are: 1) Take advantage of repeat PAH measurements pre- and post-natally
to distinguish between the biological effects of prenatal PAH exposure versus postnatal exposure during
early childhood and pre-adolescence; 2) To advance the understanding of the influence of diesel exhaust
exposures, which include PAHs, in acute asthma exacerbations by linking innovative exposure and outcome
measures; 3) To determine whether epigenetic changes related to PAH exposure are involved in the
pathogenesis of childhood asthma; 4) To ascertain if traffic related PAHs affect [32AR function in airway
smooth muscle cells in vitro, alter |32ARfunction following in utero and early life exposures, affect P2AR
expression and function in airway epithelial cells in vitro. The research is translational to asthma prevention,
clinical treatment, physician education, and policy.
该提案是为了响应 RFA-ES-06-001 DISCOVER 倡议而提交的。胎儿和幼年
孩子有独特的生理、发育、代谢和行为模式
容易受到环境中危险的影响。环境空气污染被认为是主要风险因素
对于哮喘和哮喘恶化,然而流行病学研究受到以下因素的阻碍
暴露的不确定性和气道反应的性质。
哥伦比亚儿童环境健康中心 (CCCEH) 疾病调查
环境研究专业临床导向企业 (DISCOVER) 旨在了解
空气中的多环芳烃 (PAH) 和柴油机尾气颗粒 (DEP) 何时以及如何
增加儿童哮喘和气道炎症的风险,开发新的生物标志物来识别儿童
面临风险并改善临床治疗,评估公共政策干预的成功,并实施
医生教育举措作为一种干预模式。
该提案包括四个密切相关的项目以及行政和数据管理以及
生物统计学核心确保参与此项研究的多项研究活动的无缝协调
提议。核心在研究信息和统计分析的质量以及
四个主要 DISCOVER 研究项目的行政/财务监督和转化部分1
倡议。四个项目目标是: 1) 利用产前和产后重复 PAH 测量
区分产前 PAH 暴露与产后暴露的生物效应
幼儿期和青春期前; 2) 加深对柴油机尾气影响的认识
通过将创新暴露与结果联系起来,了解哮喘急性发作中的暴露(包括多环芳烃)
措施; 3) 确定与PAH暴露相关的表观遗传变化是否参与
儿童哮喘的发病机制; 4) 确定交通相关的 PAH 是否影响气道中的 [32AR 功能
体外平滑肌细胞,在子宫内和早期生命暴露后改变 |32AR 功能,影响 P2AR
体外气道上皮细胞中的表达和功能。该研究可转化为哮喘预防,
临床治疗、医生教育和政策。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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RACHEL L MILLER其他文献
RACHEL L MILLER的其他文献
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{{ truncateString('RACHEL L MILLER', 18)}}的其他基金
Mitochondrial DNA biomarkers to assess responses to changes in personal environmental exposures in pediatric urban asthma
线粒体 DNA 生物标志物可评估城市儿童哮喘对个人环境暴露变化的反应
- 批准号:
10047663 - 财政年份:2019
- 资助金额:
$ 65.05万 - 项目类别:
Pregnancy and Prenatal PAHs and other Environmental Exposures and Breast Cancer
怀孕和产前多环芳烃和其他环境暴露与乳腺癌
- 批准号:
9145662 - 财政年份:2015
- 资助金额:
$ 65.05万 - 项目类别:
Secondhand smoke and asthma: Mechanistic outcomes of DNA methylation in T cells
二手烟与哮喘:T 细胞 DNA 甲基化的机制结果
- 批准号:
8791343 - 财政年份:2014
- 资助金额:
$ 65.05万 - 项目类别:
Secondhand smoke and asthma: Mechanistic outcomes of DNA methylation in T cells
二手烟与哮喘:T 细胞 DNA 甲基化的机制结果
- 批准号:
9197326 - 财政年份:2014
- 资助金额:
$ 65.05万 - 项目类别:
Secondhand smoke and asthma: Mechanistic outcomes of DNA methylation in T cells
二手烟与哮喘:T 细胞 DNA 甲基化的机制结果
- 批准号:
8630582 - 财政年份:2014
- 资助金额:
$ 65.05万 - 项目类别:
Mouse allergen intervention and DNA methylation of asthma regulatory genes
小鼠过敏原干预和哮喘调节基因的 DNA 甲基化
- 批准号:
8496706 - 财政年份:2012
- 资助金额:
$ 65.05万 - 项目类别:
Mouse allergen intervention and DNA methylation of asthma regulatory genes
小鼠过敏原干预和哮喘调节基因的 DNA 甲基化
- 批准号:
8350980 - 财政年份:2012
- 资助金额:
$ 65.05万 - 项目类别:
Windows of Susceptibility to PAH/DEP Exposure and Asthma
PAH/DEP 暴露和哮喘的易感性窗口
- 批准号:
8279273 - 财政年份:2011
- 资助金额:
$ 65.05万 - 项目类别:
Black carbon exposure, DNA methylation, airway inflammation in pediatric asthma
黑碳暴露、DNA 甲基化、小儿哮喘气道炎症
- 批准号:
8236573 - 财政年份:2005
- 资助金额:
$ 65.05万 - 项目类别:
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