Impact of the autoimmunity associated PTPN22 1858T

自身免疫相关的影响 PTPN22 1858T

• 批准号: 8128210
• 负责人: Jane Hoyt Buckner
• 金额: $ 45.55万
• 依托单位: BENAROYA RESEARCH INST AT VIRGINIA MASON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2011-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128210
• 关键词: Address; Alleles; Amino Acids; Autoimmune Diabetes; Autoimmune Diseases; Autoimmunity; Binding; Biochemical; CD4 Positive T Lymphocytes; Carrier Proteins; Cell Survival; Cell physiology; Cells; Development; Disease; Genes; Genetic Variation; Genotype; Grant; Graves' Disease; Health; Human; Immune; Immune response; Immune system; Immunization; Impairment; In Vitro; Individual; Insulin-Dependent Diabetes Mellitus; Lead; Link; Measures; Memory; Molecular; Myasthenia Gravis; PTPN22 gene; Pathway interactions; Peripheral; Phenotype; Phosphoric Monoester Hydrolases; Play; Pneumococcal conjugate vaccine; Polyvalent pneumococcal vaccine; Population; Predisposition; Production; Protein Tyrosine Phosphatase; Receptor Signaling; Role; Shapes; Signal Pathway; Signal Transduction; Systemic Lupus Erythematosus; T cell response; T memory cell; T-Cell Receptor; T-Lymphocyte; Testing; Vaccination; Variant; cross reacting material 197; cytokine; functional outcomes; gain of function; genetic variant; genome wide association study; human subject; in vivo; inhibitor/antagonist; memory CD4 T lymphocyte; peripheral tolerance; public health relevance; response