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Impact of the autoimmunity associated PTPN22 1858T

Impact of the autoimmunity associated PTPN22 1858T
自身免疫相关的影响 PTPN22 1858T
批准号：
8128210
负责人：
Jane Hoyt Buckner
金额：
$45.55万
依托单位：
BENAROYA RESEARCH INST AT VIRGINIA MASON
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
项目状态：
已结题
起止时间：
2010-09-01 至 2011-08-14
来源：
https://reporter.nih.gov/project-details/8128210
关键词：
AddressAllelesAmino AcidsAutoimmune DiabetesAutoimmune DiseasesAutoimmunityBindingBiochemicalCD4 Positive T LymphocytesCarrier ProteinsCell SurvivalCell physiologyCellsDevelopmentDiseaseGenesGenetic VariationGenotypeGrantGraves&apos DiseaseHealthHumanImmuneImmune responseImmune systemImmunizationImpairmentIn VitroIndividualInsulin-Dependent Diabetes MellitusLeadLinkMeasuresMemoryMolecularMyasthenia GravisPTPN22 genePathway interactionsPeripheralPhenotypePhosphoric Monoester HydrolasesPlayPneumococcal conjugate vaccinePolyvalent pneumococcal vaccinePopulationPredispositionProductionProtein Tyrosine PhosphataseReceptor SignalingRoleShapesSignal PathwaySignal TransductionSystemic Lupus ErythematosusT cell responseT memory cellT-Cell ReceptorT-LymphocyteTestingVaccinationVariantcross reacting material 197cytokinefunctional outcomesgain of functiongenetic variantgenome wide association studyhuman subjectin vivoinhibitor/antagonistmemory CD4 T lymphocyteperipheral tolerancepublic health relevanceresponse

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