Immunophenotyping and Lymphocyte Effector Functions in Sarcoidosis

结节病的免疫表型和淋巴细胞效应器功能

• 批准号: 8128048
• 负责人: LAURA L KOTH
• 金额: $ 38.63万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-27 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8128048
• 关键词: Adrenal Cortex Hormones; Area; Autoantigens; Biological; Biological Assay; Biology; Blood; Blood Circulation; Bronchoalveolar Lavage Fluid; CD8B1 gene; Cells; Cellular biology; Characteristics; Chronic; Clinical; Clinical Research; Data; Development; Disease; Disease Progression; Educational workshop; Effector Cell; Etiology; Frequencies; Funding; Future; Goals; Granuloma; Granulomatous; Health; Home environment; Homologous Gene; Human; Immune response; Immune system; Immunology; Immunophenotyping; In Vitro; Individual; Inflammation; Inflammatory; Inflammatory Response; Interferons; Interleukin-17; Knowledge; Left; Life; Longitudinal Studies; Lung; Lung diseases; Lymphocyte; Measurement; Measures; Mediastinal lymph node group; Mediating; Morbidity - disease rate; Mus; NCAM1 gene; National Heart, Lung, and Blood Institute; Natural History; Nature; Pathogenesis; Patients; Phenotype; Pilot Projects; Play; Production; Progressive Disease; Property; Pulmonary Sarcoidosis; Recruitment Activity; Research; Research Project Grants; Respiratory physiology; Role; Sarcoidosis; Severities; Severity of illness; Steroids; Surface; Symptoms; T-Lymphocyte; T-Lymphocyte Subsets; Testing; Time; Toxic effect; United States National Institutes of Health; X-Ray Computed Tomography; airway inflammation; airway obstruction; arm; base; cohort; cytokine; cytotoxicity; disease phenotype; human disease; improved; killer T cell; mortality; mouse model; new therapeutic target; novel; patient oriented; prevent; public health relevance; research study; response

项目成果

Interferon-inducible chemokines reflect severity and progression in sarcoidosis.

• DOI: 10.1186/1465-9921-14-121
• 发表时间: 2013-11-07
• 期刊: Respiratory research
• 影响因子: 5.8
• 作者: Su R;Nguyen ML;Agarwal MR;Kirby C;Nguyen CP;Ramstein J;Darnell EP;Gomez AD;Ho M;Woodruff PG;Koth LL
• 通讯作者: Koth LL

Longitudinal analysis of sarcoidosis blood transcriptomic signatures and disease outcomes.

结节病血液转录组特征和疾病结果的纵向分析。

• DOI: 10.1183/09031936.00039714
• 发表时间: 2014
• 期刊: The European respiratory journal
• 作者: Su,Robert;Li,MichaelM;Bhakta,NiravR;Solberg,OwenD;Darnell,EliPB;Ramstein,Joris;Garudadri,Suresh;Ho,Melissa;Woodruff,PrescottG;Koth,LauraL
• 通讯作者: Koth,LauraL