A Compact Instrument for Time-Resolved Airborne Particle Chemistry

描述（由申请人提供）：本提案旨在满足对直径低于2.5 5 m的大气颗粒物的化学成分进行广泛的时间分辨测量的需求。这些细颗粒与发病率和死亡率增加有关。它们通过对全球气候的影响以及对云的形成、消散和寿命的影响，在公共卫生方面发挥间接作用。我们的方法使用了一个“智能”采样器，它可以在单个收集晶片上收集连续的、随时可以分析的样品，在晶片上写有所有相关的收集数据，如位置、时间和空气体积。收集晶片在实验室中由自动进样器离子色谱系统处理，该系统提取、注入和分析样品，而无需实验室操作员手动处理。此外，对实验室系统进行编程以读取晶片上的闪存并将分析数据与收集信息联合收割机组合以产生简化的数据集，其中分析物浓度以5g/m3空气表示。该项目旨在通过正在进行的开发和现场测试，结合正在进行的NIH资助的流行病学研究和环境空气监测计划，改进，验证和演示该系统。它还寻求扩展分析能力，包括更快，更灵敏的芯片实验室分析方法。我们的目标是为环境监测和暴露评估研究提供一种具有成本效益的方法，用于每小时分辨的空气颗粒物化学成分监测。 公共卫生相关性：空气中的小颗粒与发病率和死亡率的增加有关，并通过影响云的形成和寿命来影响全球气候。该提案解决了需要更好地了解这些颗粒的来源和浓度，提供了一个负担得起的时间分辨分析其化学成分的手段。

DESCRIPTION (provided by applicant): This proposal addresses the need to provide widespread, time-resolved measurement of the chemical composition of atmospheric particles that are below 2.5 5m in diameter. These fine particles have been associated with increased morbidity and mortality. They play an indirect role in public health through their influence on global climate and their influence on the formation, albedo and lifetime of clouds. Our approach uses a "smart" sampler that collects sequential, ready-to-analyze samples on a single collection wafer, onto which is written all of the relevant collection data such as location, time and air volume. The collection wafer is handled in the laboratory by an autosampler ion chromatograph system that extracts, injects and analyzes the samples without manual handling by the laboratory operator. Further, the laboratory system is programmed to read the flash memory on the wafer and to combine the analytical data with the collection information to produce a reduced data set, with analyte concentrations expressed in 5g/m3 of air. This project seeks to refine, validate and demonstrate this system through ongoing development and field testing in conjunction with on-going NIH-funded epidemiology studies and ambient air monitoring programs. It also seeks to extend analytical capabilities to include the faster, more sensitive lab-on-a-chip analysis methods. We aim to provide a cost-effective method for hourly- resolved monitoring of the chemical constituents of airborne particulate for both environmental monitoring and exposure assessment studies. PUBLIC HEALTH RELEVANCE: Small airborne particles are associated with increased morbidity and mortality, and affect global climate through their influence on the formation and lifetime of clouds. This proposal addresses the need to better understand the origins and concentrations of these particles by providing an affordable means for time-resolved assay of their chemical composition.