Measuring Endoscopic Probe - A Novel Supportive Tool for Endoscopy

测量内窥镜探头——一种新型内窥镜辅助工具

• 批准号: 7910253
• 负责人: VLADIMIR RUBTSOV
• 金额: $ 13.9万
• 依托单位: INTELLIGENT OPTICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7910253
• 关键词: Address; Algorithms; Area; Biological; Caliber; California; Collaborations; Colonoscopes; Color; Communities; Computer software; Data; Development; Devices; Diagnosis; Diagnostic; Diagnostic Procedure; Dimensions; Endoscopes; Endoscopy; Engineering; Esophagus; Evaluation; Excision; Expert Systems; Fiber Optics; Fingers; Foundations; Funding; Goals; Grant; Hand; Image; Laboratories; Lesion; Lighting; Los Angeles; Measurement; Measures; Mechanics; Medical; Medical center; Methods; Nanomanufacturing; Operative Surgical Procedures; Optics; Phase; Photogrammetry; Physicians; Polyps; Procedures; Process; Reproduction; Research; Research Personnel; Sampling; Schools; Secure; System; Technology; Time; Tissues; Uncertainty; Universities; Visual; base; commercialization; cost; design; instrument; lens; next generation; novel; operation; prototype; public health relevance; restoration; software development; tool

DESCRIPTION (provided by applicant): Noncontact remote dimensional measurements in difficult to access areas are an important part of nondestructive remote visual evaluation in many industrial fields. Endoscopes are the major devices that are used for this purpose. It is impossible, however, to measure the actual size of the imaged objects using an endoscope that is not equipped with additional features, as the instrument magnifies object details depending on its distance from the endoscope tip, and this distance is unknown, and is constantly changing during the examination. This measurement situation changed, in 1996, when Olympus Industrial introduced a two objective measuring endoscope that produced an optical stereopair that could be used to determine distance via the triangulation method used in classical two-camera photogrammetry. The diameter of the outer shaft of this endoscope is 4.4mm, and the device is widely used in the industrial field. The medical community, however, has not embraced this device, most likely for two reasons: (i) a reduced angle of view (700) compared to the larger angle of view (more than1100) used in endoscopic visual examination; and (ii) the high cost involved in the measurement process. Diagnostic endoscopy is typically qualitative. The physicians make conclusions from observation of the tissue colors and abnormalities. High quality color reproduction devices with a wide field of view are in use. As medical diagnostics progresses, however, there are more requests for quantative measurements during endoscopy. The development of an endoscopic supportive tool with measurement capabilities, that will not interrupt the endoscopic procedure, but can rapidly provide quantative support to the diagnosis, would be valuable to medical practitioners. This tool would best be delivered through the instrumental channel of the endoscope, as are other supportive tools. The diameter of the instrumental channel is restricted, however, and a two lens probe, such as the Olympus probe, will not fit in the channel. Intelligent Optical Systems (IOS) is collaborating with the UCLA Medical Center and School of Engineering to develop technologies specifically focused on the fabrication of novel unique surgical tools and MEMS devices to enhance endoscope measurement capabilities. IOS has developed and proven a method of producing a stereopair using a single lens with an optically transparent tilting plate in front of the lens. UCLA researchers have fabricated and demonstrated the operability of a MEMS device incorporating an optically transparent plate. In this project, the IOS-UCLA team proposes to develop a single lens endoscopic measuring probe no more than 2.5mm in diameter. In Phase I, the team will fabricate and demonstrate a measuring endoscope probe prototype 5.5mm in diameter, based on an already fabricated tilting plate; develop measurement algorithms and software, and modify the MEMS fabrication flow process to downsize the device to the 2.5mm dimension. A precommercial prototype of the measuring endoscopic probe, ready for FDA approval, will be presented at the end of Phase II. PUBLIC HEALTH RELEVANCE: Requirements for quantifying the size of lesions, polyps, and other pathological parts of tissue during endoscopy diagnostics, are growing. Reliable, low cost, high accuracy tools to support endoscopy procedures with quantative data, however, do not exist. IOS, in collaboration with UCLA researchers, proposes to develop a measuring endoscopic probe, a tool that can be inserted into the instrumental channel of the endoscope, and will provide dimensional measurements of biological objects during endoscopic procedures. This novel tool will help to reduce the number of uncertainties that still exist in endoscopy diagnosis.

描述（由申请人提供）：在难以接近的区域进行非接触式远程尺寸测量是许多工业领域中无损远程视觉评估的重要组成部分。内窥镜是用于此目的的主要器械。然而，使用未配备附加功能的内窥镜测量成像对象的实际尺寸是不可能的，因为仪器根据其与内窥镜尖端的距离放大对象细节，并且该距离是未知的，并且在检查期间不断变化。1996年，奥林巴斯工业公司推出了一种双物镜测量内窥镜，该内窥镜产生的光学立体对可用于通过经典双相机摄影测量中使用的三角测量方法确定距离。该内窥镜的外轴直径为4.4mm，该装置广泛应用于工业领域。然而，医学界还没有接受这种设备，最可能的原因有两个：（i）与内窥镜视觉检查中使用的较大视角（超过1100）相比，视角（700）减小;以及（ii）测量过程中涉及的高成本。诊断性内窥镜检查通常是定性的。医生通过观察组织颜色和异常情况得出结论。使用具有宽视场的高质量颜色再现设备。然而，随着医学诊断的进步，对内窥镜检查期间的定量测量有更多的要求。开发一种具有测量能力的内窥镜支持工具，该工具不会中断内窥镜手术，但可以快速地为诊断提供定量支持，这对医学从业者来说是有价值的。该工具最好通过内窥镜的器械通道输送，其他支持工具也是如此。然而，仪器通道的直径是有限的，并且双透镜探针（例如Olympus探针）将不适合通道。智能光学系统（IOS）正在与加州大学洛杉矶分校医学中心和工程学院合作，开发专门用于制造新型独特手术工具和MEMS设备的技术，以增强内窥镜测量能力。IOS已经开发并证明了一种使用单个透镜产生立体对的方法，其中在透镜前面具有光学透明的倾斜板。加州大学洛杉矶分校的研究人员已经制造并展示了一个包含光学透明板的MEMS器件的可操作性。在该项目中，IOS-UCLA团队建议开发一种直径不超过2.5 mm的单透镜内窥镜测量探头。在第一阶段，该团队将基于已经制造的倾斜板制造和演示直径为5.5 mm的测量内窥镜探头原型;开发测量算法和软件，并修改MEMS制造流程，将设备尺寸缩小到2.5 mm。在第二阶段结束时，将提交一个准备好等待FDA批准的测量内窥镜探头的预商业化原型。 公共卫生相关性：在内窥镜诊断期间，对病变、息肉和组织的其他病理部分的尺寸进行量化的需求正在增长。然而，不存在可靠的、低成本的、高精度的工具来支持具有定量数据的内窥镜检查程序。IOS与加州大学洛杉矶分校的研究人员合作，建议开发一种测量内窥镜探头，这是一种可以插入内窥镜仪器通道的工具，并将在内窥镜手术期间提供生物物体的尺寸测量。这种新的工具将有助于减少内窥镜诊断中仍然存在的不确定性。