Prospective predictors of alcohol expectancies in children with and without ADHD

患有和不患有多动症的儿童酒精预期的前瞻性预测因素

• 批准号: 8064229
• 负责人: Steve Lee
• 金额: $ 3.85万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-20 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8064229
• 关键词: 10 year old; 8 year old; 9 year old; Adolescence; Adopted; Age; Alcohol abuse; Alcohol consumption; Alcohols; Area; Attention deficit hyperactivity disorder; Behavioral; Caucasians; Caucasoid Race; Child; Childhood; Clinical; Cognitive; Communities; Comorbidity; Conduct Disorder; Cross-Sectional Studies; Data; Dependence; Detection; Development; Disease; Disruptive Behavior Disorder; Ethnic Origin; Expectancy; Family; Follow-Up Studies; Funding; Future; Goals; Grant; Impairment; Individual; Intervention; Interview; Interviewer; Longitudinal Studies; Measures; Methods; Modeling; Modification; Moods; Neurocognitive; Oppositional Defiant Disorder; Outcome; Parenting behavior; Parents; Phenotype; Positioning Attribute; Prevention; Preventive Intervention; Prospective Studies; Psychopathology; Public Health; Race; Research; Research Personnel; Risk Factors; Sampling; School-Age Population; Seeds; Short-Term Memory; Structure; Substance Use Disorder; Taste Perception; Testing; Time; Time Study; Traction; addiction; alcohol expectancy; alcohol use disorder; alcohol use initiation; analog; base; early adolescence; early alcohol use; effective intervention; executive function; follow-up; functional disability; high risk; improved; informant; innovation; neuropsychological; peer; prevent; programs; prospective; public health relevance; response; sex; social; socioeconomics; teacher

DESCRIPTION (provided by applicant): Despite the clinical and public health significance of alcohol use disorders, relatively little is known about the childhood risk factors that precede alcohol problems. This implies that future studies must adopt a more developmentally-informed approach to the study of the timing (i.e., onset), sequencing, and progression from initial alcohol expectancies to alcohol use initiation, and to alcohol problems. Using a rigorously characterized sample of ethnically- and socioeconomically-diverse 200-225 6-9 year-old children with and without attention- deficit/hyperactivity disorder (ADHD), the proposed study aims to conduct a two-year prospective longitudinal study to understand the behavioral, neuropsychological, and family predictors of early alcohol expectancies and alcohol engagement. At baseline, children and families were comprehensively assessed using a mixture of multiple methods (i.e., rating scales, structured and semi-structured interviews, analogue, observational) and informants (i.e., parent, interviewer, teacher) across cognitive, academic, neuropsychological, family, and psychopathology domains. The proposed follow-up will preserve similar methods/constructs as baseline, with appropriate developmental modifications, to facilitate cross-time comparisons. However, the focus of the prospective follow-up is to incorporate rigorous and developmentally-sensitive assessments of alcohol-related phenotypes in children and parents. Our long-term goal is to leverage this large cross-sectional study of children with and without ADHD into a highly-informative prospective longitudinal study of the behavioral, neuropsychological, and family precursors of alcohol use disorders and related problems. Based on the premise that innovations in intervention and prevention can be expected from studies that identify potential causal risk factors for alcohol expectancies, use initiation, and escalation of alcohol use, we anticipate that findings from this study will help to reduce the considerable clinical and public health burden associated with alcohol use disorders. PUBLIC HEALTH RELEVANCE: To date, there are relatively few studies that have identified childhood precursors of alcohol expectancies and explicit use. The proposed study will help elucidate the behavioral, neuropsychological, and family determinants of alcohol expectancies and use in school-aged children. This study will also position the investigative team to follow this well-characterized sample into early adolescence and to characterize the timing and sequencing of alcohol use initiation and escalation.

描述(由申请人提供)：尽管酒精使用障碍具有临床和公共卫生意义，但人们对酒精问题之前的儿童风险因素知之甚少。这意味着未来的研究必须采用一种更了解发育的方法来研究从最初的饮酒预期到酒精使用开始，再到酒精问题的时间选择(即发病)、顺序和进展。通过对200-225名患有和不患有注意力缺陷/多动障碍(ADHD)的6-9岁儿童进行严格表征的种族和社会经济学样本，这项拟议的研究旨在进行一项为期两年的前瞻性纵向研究，以了解早期饮酒预期和饮酒行为的行为、神经心理和家庭预测因素。在基线阶段，使用多种方法(即评分表、结构化和半结构化访谈、模拟、观察性)和告密者(即家长、面试者、教师)对儿童和家庭进行全面评估，涉及认知、学术、神经心理、家庭和精神病理学领域。拟议的后续行动将保留类似的方法/结构作为基线，并进行适当的发展修改，以便利跨时间的比较。然而，前瞻性随访的重点是纳入对儿童和父母的酒精相关表型的严格和发育敏感的评估。我们的长期目标是利用这项对患有和不患有ADHD的儿童进行的大型横断面研究，对酒精使用障碍和相关问题的行为、神经心理和家庭前驱进行具有高度信息量的前瞻性纵向研究。基于这样的前提，即通过研究确定酒精预期、开始使用和酒精使用升级的潜在原因风险因素，可以预期干预和预防方面的创新，我们预计这项研究的结果将有助于减轻与酒精使用障碍相关的相当大的临床和公共卫生负担。 与公共卫生相关：到目前为止，确定儿童饮酒预期和明确饮酒的前兆的研究相对较少。这项拟议的研究将有助于阐明学龄儿童饮酒预期和饮酒的行为、神经心理和家庭决定因素。这项研究还将使调查小组跟随这一特征良好的样本进入青春期早期，并确定酒精使用开始和升级的时间和顺序。