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Prospective predictors of alcohol expectancies in children with and without ADHD

患有和不患有多动症的儿童酒精预期的前瞻性预测因素

基本信息

批准号：
8144481
负责人：
Steve Lee
金额：
$ 3.7万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-20 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8144481
关键词：
10 year old 8 year old 9 year old Adolescence Adopted Age Alcohol abuse Alcohol consumption Alcohol or Other Drugs use Alcohols Area Attention deficit hyperactivity disorder Behavioral Caucasians Caucasoid Race Child Childhood Clinical Cognitive Communities Comorbidity Conduct Disorder Cross-Sectional Studies Data Dependence Detection Development Disease Disruptive Behavior Disorder Ethnic Origin Expectancy Family Funding Future Goals Grant Impairment Individual Intervention Interview Interviewer Longitudinal Studies Measures Methods Modeling Modification Moods Neurocognitive Oppositional Defiant Disorder Outcome Parenting behavior Parents Phenotype Positioning Attribute Prevention Preventive Intervention Prospective Studies Psychopathology Public Health Race Research Research Personnel Risk Factors Sampling School-Age Population Short-Term Memory Structure Substance Use Disorder Taste Perception Testing Time Time Study Traction addiction alcohol expectancy alcohol use disorder alcohol use initiation analog base early adolescence early alcohol use effective intervention executive function follow-up functional disability high risk improved informant innovation neuropsychological peer prevent programs prospective public health relevance response sex social socioeconomics teacher

项目摘要

DESCRIPTION (provided by applicant): Despite the clinical and public health significance of alcohol use disorders, relatively little is known about the childhood risk factors that precede alcohol problems. This implies that future studies must adopt a more developmentally-informed approach to the study of the timing (i.e., onset), sequencing, and progression from initial alcohol expectancies to alcohol use initiation, and to alcohol problems. Using a rigorously characterized sample of ethnically- and socioeconomically-diverse 200-225 6-9 year-old children with and without attention- deficit/hyperactivity disorder (ADHD), the proposed study aims to conduct a two-year prospective longitudinal study to understand the behavioral, neuropsychological, and family predictors of early alcohol expectancies and alcohol engagement. At baseline, children and families were comprehensively assessed using a mixture of multiple methods (i.e., rating scales, structured and semi-structured interviews, analogue, observational) and informants (i.e., parent, interviewer, teacher) across cognitive, academic, neuropsychological, family, and psychopathology domains. The proposed follow-up will preserve similar methods/constructs as baseline, with appropriate developmental modifications, to facilitate cross-time comparisons. However, the focus of the prospective follow-up is to incorporate rigorous and developmentally-sensitive assessments of alcohol-related phenotypes in children and parents. Our long-term goal is to leverage this large cross-sectional study of children with and without ADHD into a highly-informative prospective longitudinal study of the behavioral, neuropsychological, and family precursors of alcohol use disorders and related problems. Based on the premise that innovations in intervention and prevention can be expected from studies that identify potential causal risk factors for alcohol expectancies, use initiation, and escalation of alcohol use, we anticipate that findings from this study will help to reduce the considerable clinical and public health burden associated with alcohol use disorders. PUBLIC HEALTH RELEVANCE: To date, there are relatively few studies that have identified childhood precursors of alcohol expectancies and explicit use. The proposed study will help elucidate the behavioral, neuropsychological, and family determinants of alcohol expectancies and use in school-aged children. This study will also position the investigative team to follow this well-characterized sample into early adolescence and to characterize the timing and sequencing of alcohol use initiation and escalation.

描述（由申请人提供）：尽管酒精使用障碍具有临床和公共卫生意义，但人们对酒精问题之前的儿童危险因素知之甚少。这意味着未来的研究必须采用一种更加注重发展的方法来研究从最初的饮酒预期到开始饮酒以及到酒精问题的时间（即开始）、顺序和进展。拟议的研究使用严格表征的 200-225 名患有或不患有注意力缺陷/多动障碍 (ADHD) 的 6-9 岁儿童样本，该样本具有种族和社会经济多样性，旨在进行一项为期两年的前瞻性纵向研究，以了解早期饮酒预期和饮酒参与的行为、神经心理学和家庭预测因素。在基线时，使用多种方法（即评级量表、结构化和半结构化访谈、模拟、观察）和认知、学术、神经心理学、家庭和精神病理学领域的信息提供者（即家长、访谈者、教师）对儿童和家庭进行全面评估。拟议的后续行动将保留类似的方法/结构作为基线，并进行适当的开发修改，以促进跨时间比较。然而，前瞻性随访的重点是对儿童和父母的酒精相关表型进行严格且发育敏感的评估。我们的长期目标是利用这项针对患有和不患有多动症的儿童的大型横断面研究，对酒精使用障碍及相关问题的行为、神经心理学和家庭先兆进行信息丰富的前瞻性纵向研究。基于这样的前提，即通过研究确定饮酒预期、饮酒开始和饮酒升级的潜在因果风险因素，可以预期干预和预防方面的创新，我们预计这项研究的结果将有助于减轻与酒精使用障碍相关的相当大的临床和公共卫生负担。公共卫生相关性：迄今为止，确定儿童时期饮酒预期和明确饮酒前兆的研究相对较少。拟议的研究将有助于阐明学龄儿童饮酒预期和使用的行为、神经心理学和家庭决定因素。这项研究还将帮助调查团队跟踪这一特征明确的样本直至青春期早期，并确定饮酒开始和升级的时间和顺序。