POLYMODAL NEUROIMAGING IN GENETICALLY DETERMINED PARKINSON'S DISEASE

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 在本申请中，我们计划调查的病理生理学和病理解剖学在遗传决定和特发性帕金森病（PD）在不同阶段的PD（无症状和症状阶段）。我们提出以下目标：首先，使用正电子发射断层扫描，测量局部脑多巴胺浓度和葡萄糖代谢的遗传决定（LRRK 2突变携带者）和特发性PD患者和正常志愿者，以确定特定的脑代谢异常的PD。第二，使用磁共振成像（MRI），调查结构模式的遗传决定（LRRK 2突变携带者）和特发性PD患者和正常志愿者，以确定具体的异常大脑结构的PD。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this application we plan to investigate the pathophysiology and pathoanatomy in genetically determined and idiopathic Parkinson's disease (PD) in different stages of PD (asymptomatic and symptomatic stage). We propose the following aims: First, using positron emission tomography, to measure regional cerebral dopamine concentration and glucose metabolism in patients with genetically determined (LRRK2 mutation carriers) and idiopathic PD and normal volunteers in order to determine the specific abnormalities of brain metabolism in PD. Second, using Magnetic-Resonance-Imaging (MRI), to investigate structural patterns in patients with genetically determined (LRRK2 mutation carriers) and idiopathic PD and normal volunteers in order to determine the specific abnormalities of brain structure in PD.