POLYMODAL NEUROIMAGING IN GENETICALLY DETERMINED PARKINSON'S DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这项应用中，我们计划研究遗传决定的和特发性帕金森病(PD)不同阶段(无症状和症状期)的病理生理学和病理解剖学。我们提出了以下目的：首先，利用正电子发射断层扫描技术，检测遗传性(LRRK2突变携带者)、特发性帕金森病患者和正常志愿者的局部脑多巴胺浓度和糖代谢，以确定帕金森病患者脑代谢的特异性异常。其次，利用磁共振成像(MRI)技术，对LRRK2基因突变携带者、特发性帕金森病患者和正常志愿者的脑结构进行研究，以确定帕金森病患者脑结构的特异性异常。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this application we plan to investigate the pathophysiology and pathoanatomy in genetically determined and idiopathic Parkinson's disease (PD) in different stages of PD (asymptomatic and symptomatic stage). We propose the following aims: First, using positron emission tomography, to measure regional cerebral dopamine concentration and glucose metabolism in patients with genetically determined (LRRK2 mutation carriers) and idiopathic PD and normal volunteers in order to determine the specific abnormalities of brain metabolism in PD. Second, using Magnetic-Resonance-Imaging (MRI), to investigate structural patterns in patients with genetically determined (LRRK2 mutation carriers) and idiopathic PD and normal volunteers in order to determine the specific abnormalities of brain structure in PD.