GENETICS OF WHITE MATTER DEFICITS IN SCHIZOPHRENIA

精神分裂症白质缺陷的遗传学

• 批准号: 8167249
• 负责人: PHILIP R SZESZKO
• 金额: $ 3.86万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167249
• 关键词: Brain; Computer Retrieval of Information on Scientific Projects Database; Data; Databases; Funding; Genes; Genetic; Genetic Variation; Grant; Individual; Institution; Magnetic Resonance Imaging; Measures; Mental disorders; Patients; Protocols documentation; Research; Research Ethics Committees; Research Personnel; Resources; Schizophrenia; Source; Structure; United States National Institutes of Health; healthy volunteer; in vivo; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The aim of this study is to examine the relationship between genetic variation and measures of brain structure and function in individuals with psychiatric disorders and healthy volunteers. In particular, we will determine the relationship between genes associated with white matter structure and in-vivo measures of brain white matter integrity in patients with schizophrenia and healthy volunteers. Archival data will be obtained through the IRB-approved protocol entitled "Data repository for Magnetic Resonance Imaging (MRI) Scans of Psychiatric Patients and Healthy Volunteers."

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本研究的目的是研究精神疾病患者和健康志愿者的遗传变异与脑结构和功能测量之间的关系。 特别是，我们将确定与白色物质结构相关的基因和精神分裂症患者和健康志愿者脑白色物质完整性的体内测量之间的关系。 将通过IRB批准的方案（标题为“精神病患者和健康志愿者磁共振成像（MRI）扫描的数据存储库”）获得存档数据。"