GENETICS OF BRAIN STRUCTURE AND FUNCTION

脑结构和功能的遗传学

• 批准号: 7719261
• 负责人: PHILIP R SZESZKO
• 金额: $ 0.18万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-22 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719261
• 关键词: Anterior; Brain; Brain-Derived Neurotrophic Factor; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Funding; Genes; Genetic; Genetic Polymorphism; Genetic Variation; Grant; Hippocampus (Brain); Individual; Institution; Lead; Magnetic Resonance Imaging; Measures; Memory; Molecular; Molecular Genetics; Morphology; Patients; Play; Proteins; Research; Research Personnel; Resources; Role; Schizophrenia; Shapes; Source; Structure; Testing; United States National Institutes of Health; base; brain size; cognitive function; endophenotype; healthy volunteer; neuroimaging; novel

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. There is limited data regarding the molecular basis for alterations in brain size, shape or function in schizophrenia. One gene, brain derived neurotrophic factor (BDNF), is a secreted protein that is widely expressed in the hippocampus. BDNF has been found to play a role in hippocampal morphology and associated cognitive functions such as memory. To date, few studies have examined the relationship between BDNF polymorphism and hippocampal morphology. Moreover, prior neuroimaging studies have not distinguished between the anterior and posterior hippocampus, a critical distinction given previous data suggesting that structural and functional deficits may be most robust in the anterior hippocampus in schizophrenia. In this study, we propose assessing the relationship between magnetic resonance (MR) imaging measures of brain structure/function and genetic information in 100 healthy volunteers and 100 patients with schizophrenia. We will test the hypothesis that BDNF genetic variation is associated with anterior hippocampal structure and function and abnormalities in regions to which the anterior hippocampus is connected. These data may lead to novel endophenotypes in molecular genetic studies of schizophrenia as well as a better understanding of how genes contribute to brain development in healthy individuals.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 关于精神分裂症患者大脑大小、形状或功能变化的分子基础的数据有限。脑源性神经营养因子(BDNF)是一种分泌蛋白，在海马体中广泛表达。脑源性神经营养因子已被发现在海马区的形态和相关的认知功能，如记忆中发挥作用。到目前为止，很少有研究考察BDNF基因多态与海马形态的关系。此外，以前的神经成像研究没有区分前海马区和后海马区，这是一个关键的区别，因为之前的数据表明，结构和功能缺陷可能在精神分裂症的前海马区最明显。在这项研究中，我们建议评估100名健康志愿者和100名精神分裂症患者大脑结构/功能的磁共振成像测量与遗传信息之间的关系。我们将检验这一假设，即BDNF基因变异与前海马体结构和功能以及与前海马体相连区域的异常有关。这些数据可能会导致精神分裂症的分子遗传学研究中出现新的内表型，并更好地理解基因如何对健康个体的大脑发育做出贡献。