WHITE MATTER ENDOPHENOTYPES IN BIPOLAR DISORDER

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 本研究旨在通过弥散张量和功能性磁共振成像研究双相情感障碍患者及其未受影响的同胞与健康对照组的脑异常。我们假设，与健康志愿者相比，双相情感障碍患者的额纹状体和腹侧前额叶脑区会表现出白色异常和功能改变，而未受影响的兄弟姐妹会表现出介于双相情感障碍患者和健康志愿者之间的大脑异常模式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study aims to investigate brain abnormalities in idividuals with bipolar disorder and their unaffected siblings compared to healthy control subjects using diffusion tensor and functional magnetic resonance imaging. We hypothesize that individuals with bipolar disorder will exhibit white matter abnormalities and functional alterations in frontostriatal and ventral prefrontal brain regions comapred to healthy volunteers, and that unaffected siblings will demonstrate a pattern of brain abnormalities intermediate between individuals with bipolar disorder and healthy volunteers.