WHITE MATTER ENDOPHENOTYPES IN BIPOLAR DISORDER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本研究旨在利用扩散张量和功能磁共振成像技术研究双相情感障碍患者及其未受影响的同胞的脑异常，并与健康对照组进行比较。我们假设，与健康志愿者相比，双相情感障碍患者将在额纹状体和前额叶腹侧脑区表现出白质异常和功能变化，而未受影响的兄弟姐妹将表现出介于双相情感障碍患者和健康志愿者之间的脑异常模式。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study aims to investigate brain abnormalities in idividuals with bipolar disorder and their unaffected siblings compared to healthy control subjects using diffusion tensor and functional magnetic resonance imaging. We hypothesize that individuals with bipolar disorder will exhibit white matter abnormalities and functional alterations in frontostriatal and ventral prefrontal brain regions comapred to healthy volunteers, and that unaffected siblings will demonstrate a pattern of brain abnormalities intermediate between individuals with bipolar disorder and healthy volunteers.