WHITE MATTER ENDOPHENOTYPES IN BIPOLAR DISORDER

双相情感障碍中的白质内表型

• 批准号: 8167288
• 负责人: PHILIP R SZESZKO
• 金额: $ 0.42万
• 依托单位: FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167288
• 关键词: Bipolar Disorder; Brain; Brain region; Computer Retrieval of Information on Scientific Projects Database; Diffusion; Exhibits; Functional Magnetic Resonance Imaging; Funding; Grant; Individual; Institution; Pattern; Research; Research Personnel; Resources; Siblings; Source; United States National Institutes of Health; endophenotype; healthy volunteer; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study aims to investigate brain abnormalities in idividuals with bipolar disorder and their unaffected siblings compared to healthy control subjects using diffusion tensor and functional magnetic resonance imaging. We hypothesize that individuals with bipolar disorder will exhibit white matter abnormalities and functional alterations in frontostriatal and ventral prefrontal brain regions comapred to healthy volunteers, and that unaffected siblings will demonstrate a pattern of brain abnormalities intermediate between individuals with bipolar disorder and healthy volunteers.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究旨在使用弥散张量和功能磁共振成像研究双相情感障碍患者及其未受影响的兄弟姐妹与健康对照受试者相比的大脑异常。我们假设，与健康志愿者相比，双相情感障碍患者会表现出白质异常以及额纹状体和腹侧前额叶大脑区域的功能改变，而未受影响的兄弟姐妹将表现出介于双相情感障碍患者和健康志愿者之间的大脑异常模式。