NEUROIMAGING STUDIES OF FRONTAL LOBE PATHOLOGY IN OCD

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 很少有磁共振研究研究强迫症(OCD)患者前额叶皮质可能的结构变化，尽管这一区域对强迫症的神经生物学模型很重要。对强迫症患者额叶亚区的评估可能很重要，因为众所周知，额叶在结构和功能上都是不同的。在这项研究中，我们将使用皮质表面标测的方法来研究眼眶额叶皮质，它已经从功能神经成像研究中牵涉到强迫症的病理生理学。25名DSM-IV诊断为强迫症的患者和匹配的健康志愿者将接受磁共振成像扫描，包括124个连续的T1加权冠状SPGR磁共振图像(层厚=1.5 mm)。据推测，与健康志愿者相比，患者将表现出眼眶额部灰质密度增加，这与功能神经成像研究表明，在休息条件和症状激发时该区域的高代谢是一致的。在反应抑制指标上，灰质密度的增加与神经心理功能的恶化有关。预计这些数据将提供有关额叶皮质异常在强迫症神经生物学中的潜在作用以及结构-功能关系异常的重要信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Few magnetic resonance (MR) studies have investigated possible structural alterations of the prefrontal cortex in individuals with obsessive-compulsive disorder (OCD) despite the importance of this region to neurobiologic models of the disorder. Assessment of frontal subregions in OCD is potentially important because it is known that the frontal lobes are both structurally and functionally heterogeneous. In this study we will use methods for cortical surface mapping to investigate the orbital frontal cortex, which has been implicated in the pathophysiology of OCD from functional neuroimaging studies. Twenty-five patients with a DSM-IV diagnosis of OCD and matched healthy volunteers will receive MR imaging scans consisting of 124 contiguous T1-weighted coronal SPGR MR images (slice thickness = 1.5mm). It is hypothesized that compared to healthy volunteers, patients will demonstrate increased grey matter density in the orbital frontal region consistent with functional neuroimaging studies demonstrating hypermetabolism of this region during rest conditions and symptom provocation. Increased grey matter density will be associated with worse neuropsychological functioning on measures of response inhibition. It is expected that these data will yield important information regarding the potential role of frontal cortical abnormalities in the neurobiology of OCD as well as abnormal structure-function relations.