COMPREHENSIVE MAGNETIC RESONANCE IN PAD
PAD 中的全面磁共振
基本信息
- 批准号:8167203
- 负责人:
- 金额:$ 0.13万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-03-01 至 2013-02-28
- 项目状态:已结题
- 来源:
- 关键词:Activities of Daily LivingAffectArterial Fatty StreakAtherosclerosisBlood flowChronic Kidney FailureComputer Retrieval of Information on Scientific Projects DatabaseEvaluationExerciseFunctional disorderFundingGadoliniumGrantIndividualInstitutionKidneyKineticsLower ExtremityMagnetic ResonanceMagnetic Resonance ImagingMeasuresMethodsMusclePatientsPerfusionPeripheral arterial diseasePhosphocreatinePhysical therapy exercisesRecoveryRenal functionResearchResearch PersonnelResourcesRisk FactorsSkeletal MuscleSourceSpectrum AnalysisSpin LabelsSuperficial Femoral ArteryTestingUnited States National Institutes of HealthWalkingartery occlusionnovelprograms
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Peripheral arterial disease (PAD) is characterized by lower limb arterial obstruction due to atherosclerosis that impairs blood flow to the lower limb. PAD is quite common with over 8 million affected individuals in the U.S. Over the past 6 years, our multi-disciplinary team of investigators has developed several new magnetic resonance measures to aid in the evaluation of PAD including atherosclerotic plaque volume measures in the superficial femoral artery, phosphocreatine (PCr) recovery kinetics after exercise by 31P spectroscopy (MRS), and first-pass contrast-enhanced calf muscle perfusion at peak exercise. The latter requires gadolinium chelates which are now contraindicated in advanced chronic kidney disease, whose risk factors overlap with PAD. Quantification of muscle blood flow and flow reserve without the use of contrast would thus be desirable in PAD patients with significant renal dysfunction. We hypothesize that both contrast and non-contrast flow reserve measures in PAD are feasible, perform better at 3T than 1.5T, and are reproducible. Thus, Specific Aim #1 is to develop and test MRI methods to quantify skeletal muscle blood flow and flow reserve at peak exercise in peripheral arterial disease, both with and without contrast (arterial spin labeling or ASL) in normal subjects and in PAD. We hypothesize that these novel methods will be be able to detect changes brought about by established therapies for PAD. Specific Aim #2 is to test the ability of peak exercise measures of calf muscle perfusion reserve and energetics to detect changes in PAD patients after percutaneous revascularization. Twenty five patients will be studied before, 4-8 weeks after, and 6 months after revascularization. Specific Aim #3 is to test the ability of peak exercise measures of calf muscle perfusion reserve and energetics to detect changes in PAD patients after supervised exercise therapy. Ninety five patients will be studied before and after a 12-week exercise program. All patients in Aims 2 and 3 will undergo first pass contrast-enhanced measures of perfusion reserve or ASL depending on underlying renal function, exercise 31P MRS measures of PCr recovery kinetics, as well as functional measures including treadmill exercise, VO2 testing, and 6-minute walk. Correlations will be examined between changes in calf muscle perfusion and energetics with improvements in functional capacity.
这个子项目是许多研究子项目中的一个
由NIH/NCRR资助的中心赠款提供的资源。子项目和
研究者(PI)可能从另一个NIH来源获得了主要资金,
因此可以在其他CRISP条目中表示。所列机构为
研究中心,而研究中心不一定是研究者所在的机构。
外周动脉疾病(PAD)的特征是由于动脉粥样硬化导致的下肢动脉阻塞,损害了流向下肢的血流。在美国,PAD在超过800万受影响的个体中相当常见。在过去的6年中,我们的多学科研究人员团队开发了几种新的磁共振测量方法来帮助评估PAD,包括股浅动脉中的动脉粥样硬化斑块体积测量,运动后31 P光谱(MRS)的磷酸肌酸(PCr)恢复动力学,以及在运动高峰时的首过对比增强小腿肌肉灌注。后者需要钆螯合物,这是目前晚期慢性肾脏疾病的禁忌,其风险因素与PAD重叠。因此,在不使用造影剂的情况下定量肌肉血流量和血流储备对于具有显著肾功能不全的PAD患者是理想的。我们假设PAD中的造影剂和非造影剂血流储备测量都是可行的,在3 T下的表现优于1.5T,并且是可重复的。因此,具体目标#1是开发和测试MRI方法,以量化正常受试者和PAD中外周动脉疾病在峰值运动时的骨骼肌血流量和血流储备,包括使用和不使用造影剂(动脉自旋标记或ASL)。我们假设这些新的方法将能够检测到PAD的既定疗法所带来的变化。具体目标#2是测试小腿肌肉灌注储备和能量学的峰值运动测量值检测经皮血运重建后PAD患者变化的能力。25例患者将在血运重建前、血运重建后4-8周和血运重建后6个月进行研究。具体目标#3是测试小腿肌肉灌注储备和能量学的峰值运动测量的能力,以检测PAD患者在监督运动治疗后的变化。95名患者将在12周的运动计划前后进行研究。目标2和3中的所有患者将根据基础肾功能接受灌注储备或ASL的首过造影增强测量、PCr恢复动力学的运动31 P MRS测量以及功能测量,包括跑步机运动、VO 2测试和6分钟步行。将检查小腿肌肉灌注和能量学变化与功能能力改善之间的相关性。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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CHRISTOPHER M. KRAMER其他文献
CHRISTOPHER M. KRAMER的其他文献
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{{ truncateString('CHRISTOPHER M. KRAMER', 18)}}的其他基金
HCMR Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
肥厚型心肌病预后的 HCMR 新标志物
- 批准号:
8577787 - 财政年份:2013
- 资助金额:
$ 0.13万 - 项目类别:
HCMR Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
肥厚型心肌病预后的 HCMR 新标志物
- 批准号:
8705001 - 财政年份:2013
- 资助金额:
$ 0.13万 - 项目类别:
HCMR Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
肥厚型心肌病预后的 HCMR 新标志物
- 批准号:
8843536 - 财政年份:2013
- 资助金额:
$ 0.13万 - 项目类别:
COMPREHENSIVE MAGNETIC RESONANCE IN PERIPHERAL ARTERIAL DISEASE
外周动脉疾病的综合磁共振
- 批准号:
8167148 - 财政年份:2010
- 资助金额:
$ 0.13万 - 项目类别:
COMPREHENSIVE MAGNETIC RESONANCE IN PERIPHERAL ARTERIAL DISEASE
外周动脉疾病的综合磁共振
- 批准号:
7951458 - 财政年份:2009
- 资助金额:
$ 0.13万 - 项目类别:
COMPREHENSIVE MAGNETIC RESONANCE IN PERIPHERAL ARTERIAL DISEASE
外周动脉疾病的综合磁共振
- 批准号:
7718538 - 财政年份:2008
- 资助金额:
$ 0.13万 - 项目类别:
COMPREHENSIVE MAGNETIC RESONANCE IN PERIPHERAL ARTERIAL DISEASE
外周动脉疾病的综合磁共振
- 批准号:
7606680 - 财政年份:2007
- 资助金额:
$ 0.13万 - 项目类别:
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