SAFETY OF NEBULIZED ISOTONIC SALINE WITH ADDED ALKALINE GLYCINE SOLUTION

添加碱性甘氨酸溶液的雾化等渗盐水的安全性

• 批准号: 8167187
• 负责人: JOHN Francis HUNT
• 金额: $ 1.34万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167187
• 关键词: Acids; Aftercare; Breathing; Buffers; Cells; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Enrollment; Evaluation; Exhalation; Funding; Gases; Gastric Acid; Glycine; Grant; Institution; Isotonic Exercise; Measurement; Measures; Nitric Oxide; Oxygen; Pathologic; Production; Research; Research Personnel; Resources; Safety; Saline; Solutions; Source; Spirometry; Symptoms; Testing; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Airway pH disturbance causes diverse pathologic sequelae and can be caused by inhalation of acidic gas, aspiration of gastric acid, or production of acid by airway cells. There has been no concerted effort to therapeutically neutralize acidic airways. We hypothesize that an isotonic saline solution with added alkaline glycine buffer will be well tolerated by healthy subjects. We will enroll 10 healthy subjects for inhalation of the test compound. We will perform spirometry and measurements of exhaled breath acid and exhaled nitric oxide before and after treatment. We will examine vital signs and oxygen saturation band symptom development as part of the safety evaluation. We will perform pre-post analysis of the safety data by repeated measures ANOVA.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 气道pH值紊乱可引起多种病理后遗症，可由吸入酸性气体、吸入胃酸或气道细胞产生酸引起。 目前还没有一致的努力来治疗中和酸性气道。 我们假设健康受试者对添加碱性甘氨酸缓冲液的等渗盐水溶液具有良好的耐受性。 我们将招募 10 名健康受试者来吸入测试化合物。我们将在治疗前后进行肺活量测定以及呼出气酸和呼出一氧化氮的测量。 作为安全性评估的一部分，我们将检查生命体征和氧饱和度带症状的发展。 我们将通过重复测量方差分析对安全性数据进行事前分析。