SAFETY OF NEBULIZED ISOTONIC SALINE WITH ADDED ALKALINE GLYCINE SOLUTION

添加碱性甘氨酸溶液的雾化等渗盐水的安全性

• 批准号: 8167187
• 负责人: JOHN Francis HUNT
• 金额: $ 1.34万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167187
• 关键词: Acids; Aftercare; Breathing; Buffers; Cells; Computer Retrieval of Information on Scientific Projects Database; Data; Development; Enrollment; Evaluation; Exhalation; Funding; Gases; Gastric Acid; Glycine; Grant; Institution; Isotonic Exercise; Measurement; Measures; Nitric Oxide; Oxygen; Pathologic; Production; Research; Research Personnel; Resources; Safety; Saline; Solutions; Source; Spirometry; Symptoms; Testing; United States National Institutes of Health

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Airway pH disturbance causes diverse pathologic sequelae and can be caused by inhalation of acidic gas, aspiration of gastric acid, or production of acid by airway cells. There has been no concerted effort to therapeutically neutralize acidic airways. We hypothesize that an isotonic saline solution with added alkaline glycine buffer will be well tolerated by healthy subjects. We will enroll 10 healthy subjects for inhalation of the test compound. We will perform spirometry and measurements of exhaled breath acid and exhaled nitric oxide before and after treatment. We will examine vital signs and oxygen saturation band symptom development as part of the safety evaluation. We will perform pre-post analysis of the safety data by repeated measures ANOVA.

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