ANALYSIS OF BODY FAT USING MRI/MRS IN HEALTHY CHILDREN AND IN CYSTIC FIBROSIS

使用 MRI/MRS 分析健康儿童和囊性纤维化患者的体脂

• 批准号: 8167202
• 负责人: Talissa A Altes
• 金额: $ 1.34万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167202
• 关键词: Adult; Age; Body fat; Body mass index; Child; Childhood; Computer Retrieval of Information on Scientific Projects Database; Cystic Fibrosis; Data; Detection; Disease; Evaluation; Fatty acid glycerol esters; Funding; Grant; Height; Institution; Knowledge; Leg; Liver; Measurement; Measures; Methods; Muscle; Normal Range; Overweight; Pediatric Hospitals; Philadelphia; Population; Research; Research Personnel; Resources; Skinfold Thickness; Source; United States National Institutes of Health; Weight; arm; children with cystic fibrosis; cystic fibrosis patients; lipid metabolism; metabolic abnormality assessment; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. MRI/MRS has been shown to be a fast, safe and non-invasive method for measuring fat content in the liver and has proven to be an important tool for muscle lipid metabolism studies. Most of the prior studies on MRI/MRS of body fat have included only adults and to our knowledge no prior study has included the non-overweight pediatric population. This study will assess the liver and muscle fat content in healthy non-overweight children. Obtaining a range of normal values in healthy non-overweight children will aid in detection and evaluation of liver and muscle fat content in other diseases, such as in children with Cystic Fibrosis (CF). A prior study was performed at Children's Hospital of Philadelphia (CHOP) using MRI/MRS to assess liver and muscle fat accumulation in children with CF. One of the difficulties in interpreting the data is that normative data from healthy children of a similar weight and age is not available. The purpose of this study is to collect the normative data from healthy control subjects for comparison with the results obtained in patients with CF. In this study, healthy children 10 years or older will have their height and weight, and size of their waist, arms and legs skin fold thicknesses measured. An MRI/MRS of the liver and lower leg muscle will be performed. Body mass index (BMI) will be calculated. Hypothesis: Body fat measurements in normal weight children will differ from existing data in overweight children. The data for normal children is required for comparison with data from children with diseases such as cystic fibrosis.

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