THE ROLE OF PARATHYROID HORMONE IN RENAL OSTEODYSTROPHY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 1.确定第二次PTH-IMA测定的甲状旁腺素水平是否比第一次PTH-IMA测定的PTH水平更准确地评估慢性血液透析患者和年轻人的骨形成和骨转换。 2.探讨第二次PTH-IMA测定的甲状旁腺素水平是否比第一次PTH-IMA测定的甲状旁腺素水平更准确地评估慢性肾脏病(CKD)患者透析前的骨形成和骨转换。 3.评估肾脏和骨骼对甲状旁腺素抵抗的程度和进展，并确定甲状旁腺激素(1-84)氨基末端截短片段的丰度是否与透析前CKD青年患者的抵抗状态有关，以及在接受慢性血液透析的年轻人中是否仅与骨骼抵抗有关。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: 1. To determine whether PTH concentrations measured by 2nd PTH-IMA provide a more accurate assessment of bone formation and turnover than PTH levels obtained with 1st PTH-IMA in and young adults undergoing chronic hemodialysis. 2. To determine whether PTH concentrations measured by 2nd PTH-IMA provide a more accurate assessment of bone formation and turnover than PTH levels obtained by 1st PTH-IMA in and young adults with chronic kidney disease (CKD) prior to dialysis. 3. To assess the magnitude and progression of renal and skeletal resistance to PTH and to determine whether the abundance of amino-terminally truncated PTH(1-84) fragments contribute to the state of resistance in young adults with CKD prior to dialysis, and of skeletal resistance alone in young adults undergoing chronic hemodialysis.