THE ROLE OF PARATHYROID HORMONE IN RENAL OSTEODYSTROPHY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 具体目标： 1. 确定在接受慢性血液透析的年轻人中，通过第二次PTH-IMA测量的PTH浓度是否比通过第一次PTH-IMA获得的PTH水平更准确地评估骨形成和骨转换。 2. 确定通过第二PTH-IMA测量的PTH浓度是否能更准确地评估骨 与透析前的慢性肾病（CKD）患者和年轻成人中通过第一次PTH-IMA获得的PTH水平相比， 3. 评估肾脏和骨骼对PTH抵抗的程度和进展，并确定氨基末端截短的PTH（1-84）片段的丰度是否有助于透析前患有CKD的年轻成人的抵抗状态，以及接受慢性血液透析的年轻成人的骨骼抵抗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. SPECIFIC AIMS: 1. To determine whether PTH concentrations measured by 2nd PTH-IMA provide a more accurate assessment of bone formation and turnover than PTH levels obtained with 1st PTH-IMA in and young adults undergoing chronic hemodialysis. 2. To determine whether PTH concentrations measured by 2nd PTH-IMA provide a more accurate assessment of bone formation and turnover than PTH levels obtained by 1st PTH-IMA in and young adults with chronic kidney disease (CKD) prior to dialysis. 3. To assess the magnitude and progression of renal and skeletal resistance to PTH and to determine whether the abundance of amino-terminally truncated PTH(1-84) fragments contribute to the state of resistance in young adults with CKD prior to dialysis, and of skeletal resistance alone in young adults undergoing chronic hemodialysis.