Translational Research Training in Pediatric Nephrology

小儿肾脏病学转化研究培训

• 批准号: 9506110
• 负责人: ISIDRO B. SALUSKY
• 金额: $ 7.16万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9506110
• 关键词: Childhood; Nephrology; Research Training; Translational Research

 DESCRIPTION (provided by applicant): The proposed Translational Research Training in Pediatric Nephrology T32 program at the David Geffen School of Medicine at UCLA is designed to prepare outstanding postdoctoral scholars (MDs and/or PhDs) for academic research careers in Pediatric Nephrology and aligned disciplines, at a time of declining numbers of physician-scientists nationwide and of expanding need for improved understanding and management of chronic disease care. During the initial 5-year period, with 4 postdoctoral trainees per year, each for a 2- or, if indicated, 3-year appointment, this new training program will fill a critical need or research focused on a diverse range of developmental issues in chronic kidney disease (CKD) and will advance the goals of interdisciplinary collaboration across the T1-T4 spectrum of translational medicine through rigorous cross- training in the different concepts and methods of basic, clinical, and population- and laboratory-based approaches to CKD, including assessment of health care system impact through health services research and policy analysis. Over the last several decades, major advances have occurred in the diagnosis, treatment, and management of kidney diseases in childhood, altogether resulting in the increased life span of such patients. This success has, however, brought new health status challenges, such as cardiovascular disease (the leading cause of death), muscle-skeletal problems, growth retardation, infections, and allograft loss, among others, all of which are optimally addressed from a developmental perspective. In response to these challenges, the interdisciplinary curriculum and mentored, hands-on research training of this new program encompass the biomedical and clinical sciences, including comparative effectiveness and patient-centered outcomes research, interweaving the scientific expertise and mentoring experience of 35 high-quality multidisciplinary faculty who are committed to collaborative, team-based science. The new training program will leverage the resources of the UCLA Specialty Training and Advanced Research Program, Training Program in Translational Science (former K30), and existing K12, T32, and R25 programs for the core curriculum and protected time, all collectively geared to achieve the following specific aims: (1) expand the multidisciplinary knowledge base of life and health sciences as it relates to different aspects of pediatric kidney diseases; (2) provide didactic and experimental research training in the intellectual and philosophical foundation of clinical-translational research; (3) develop trainees' scientific writing skills for publications ad grants; (4) provide an academic environment that enables development of the research skills and experience needed for successful, independent scientific careers in academic medicine as members and leaders of interdisciplinary teams in cross-cutting research domains germane to Pediatric Nephrology; and (5) model research-empowering teaching and mentoring skills for trainees' development, including their eventual replication of research training programs in life-span CKD and co-morbidities as their careers evolve into stable, scientific independence.

 描述（申请人提供）：加州大学洛杉矶分校大卫格芬医学院拟议的儿科肾脏病T32项目转化研究培训旨在培养优秀的博士后学者（医学博士和/或博士）在儿科肾病和对齐学科的学术研究生涯，在全国范围内的医生，科学家的数量下降和扩大需要改善慢性病护理的理解和管理的时候。在最初的5年期间，每年有4名博士后培训生， 对于2年或3年的任命，这个新的培训计划将填补一个关键的需要或研究集中在一个不同的范围内的发展问题，慢性肾脏病（CKD），并将推进跨学科合作的目标，跨T1-T4谱的转化医学通过严格的交叉培训，在不同的概念和方法的基础，临床，以及基于人群和实验室的CKD方法，包括通过卫生服务研究和政策分析评估卫生保健系统的影响。在过去的几十年里，儿童肾脏疾病的诊断、治疗和管理取得了重大进展，从而延长了此类患者的寿命。然而，这一成功也带来了新的健康状况挑战，如心血管疾病（死亡的主要原因）、肌肉骨骼问题、生长迟缓、感染和同种异体移植物丢失等，所有这些都是从发展的角度得到最佳解决的。为了应对这些挑战，这个新项目的跨学科课程和指导，实践研究培训涵盖了生物医学和临床科学，包括比较有效性和以患者为中心的成果研究，将科学专业知识和指导经验交织在一起。新的培训计划将利用加州大学洛杉矶分校专业培训和高级研究计划，转化科学培训计划的资源（前K30），以及现有的K12，T32和R25计划的核心课程和保护时间，所有这些都旨在实现以下具体目标：（1）扩大生命和健康科学的多学科知识基础，因为它涉及儿科肾脏疾病的不同方面;（2）提供临床转化研究的知识和哲学基础方面的教学和实验研究培训;（3）培养学员的科学写作技能，以便出版和获得赠款;（4）提供一个学术环境，使研究技能和经验的发展所需的成功，独立的科学事业在学术医学的成员和跨学科团队的领导者在横向研究领域密切相关的儿科肾病;以及（5）为学员的发展提供示范研究授权的教学和指导技能，包括他们最终复制终身CKD和共病的研究培训计划，因为他们的职业发展到稳定的，科学的独立性。