BEHAVIORAL AND NEUROCHEMICAL CORRELATES OF PRESENILIN-1 MUTATION STATUS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 具体目标： 1. 确定临床前PS1突变携带者在接近疾病发作年龄时，在测量情景记忆和执行功能的神经心理学测试中的表现是否显著差于其非突变携带亲属。 2. 确定临床前PS1突变携带者是否比其非突变携带亲属具有更高的抑郁症患病率和更高水平的抑郁症状，尽管他们不知道自己的遗传状态。 3. 确定临床前PS1突变携带者中是否会发现AD发病机制的生物标志物（如CSF Ab寡聚体）升高。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims: 1. To determine if pre-clinical PS1 mutation carriers will perform significantly worse than their non-mutation carrying kin on neuropsychological tests measuring episodic memory and executive function as they approach the age of disease onset. 2. To determine if pre-clinical PS1 mutation carriers will have a higher prevalence of depression and higher levels of depressive symptoms than their non-mutation carrying kin despite being unaware of their genetic status. 3. To determine if biomarkers of AD pathogenesis such as CSF Ab oligomers will be found to be elevated in pre-clinical PS1 mutation carriers.