BEHAVIORAL AND NEUROCHEMICAL CORRELATES OF PRESENILIN-1 MUTATION STATUS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 具体目标： 1.确定临床前PS1突变携带者是否会在临近发病年龄时进行神经心理测试，测量情景记忆和执行功能，结果是否明显逊于携带非突变携带者的亲属。 2.确定临床前PS1突变携带者是否会比其非突变携带者的亲属有更高的抑郁患病率和更高水平的抑郁症状，尽管他们不知道他们的遗传状态。 3.探讨临床前PS1突变携带者是否存在脑脊液抗体寡聚体等AD发病标志物的升高。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Specific Aims: 1. To determine if pre-clinical PS1 mutation carriers will perform significantly worse than their non-mutation carrying kin on neuropsychological tests measuring episodic memory and executive function as they approach the age of disease onset. 2. To determine if pre-clinical PS1 mutation carriers will have a higher prevalence of depression and higher levels of depressive symptoms than their non-mutation carrying kin despite being unaware of their genetic status. 3. To determine if biomarkers of AD pathogenesis such as CSF Ab oligomers will be found to be elevated in pre-clinical PS1 mutation carriers.