-K

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 脑中的淀粉样斑块在AD的神经病理学中是明显的。 操纵这种淀粉样蛋白的产生和积累是AD干预中最被提出的机制之一。 有研究表明胆固醇和AD之间的联系，并且胆固醇水平的降低可能会改变淀粉样蛋白的加工，这反过来会降低A β的产生水平，从而减少斑块形成。 有研究表明饮食胆固醇和AD的生物标志物之间的关联，其中小鼠的高胆固醇饮食增加了A β的产生。 这些研究支持循环胆固醇可能是增加A β产生的风险因素的观点。 也有一些数据表明，胆固醇水平的差异也会影响认知功能。 研究表明，胆固醇水平升高可能与淀粉样蛋白沉积和认知功能有关，降低胆固醇可能会导致认知益处。 选择辛维他汀是因为其能够穿过血脑屏障，具有良好的安全性，并且是第二种最常用的药物。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Amyloid plaque in the brain is evident in the neuropathology of AD. The manipulation of the making and accumulating of this amyloid is one of the most proposed mechanisms in the intervention of AD. There are studies that have shown the link between cholesterol and AD and that the decreasing of the cholesterol levels may then change the processing of the amyloid which in turn would decrease the levels of A beta production decreasing plaque formation. There have been studies to show the association between dietary cholesterol and biological markers for AD where high cholesterol diets in mice increase A beta production. The studies support the notion that circulating cholesterol may be a risk factor for increasing A beta production. There is also some data show that differences in cholesterol levels also affect cognitive function. The studies indicate that elevated cholesterol levels may be related to amyloid deposits and cognitive function and that lowering the cholesterol may lead to cognitive benefit. Simvistatin was chosen due to its ability to cross blood brain barrier, has a good safety profile and it is the second most commonly used agent.