The Aging Brain: Vasculature, Ischemia, and Behavior

大脑老化：脉管系统、缺血和行为

• 批准号: 7848856
• 负责人: HELENA Chang CHUI
• 金额: $ 186.72万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-15 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7848856
• 关键词: Aging; Brain; Vasculature; Ischemia; Behavior

DESCRIPTION (provided by applicant): The overarching goal of this competitive renewal application is to examine the pleiotropic effects of arteriosclerosis (AS), on brain structure and function, either alone or in combination with Alzheimer disease (AD). We propose a prospective, longitudinal study of a convenience sample (231 current + 276 new = 507 subjects), selected using the Framingham cardiovascular risk profile (FCRP) to ensure representation of subjects ranging from little to severe arteriosclerosis (AS). The PPG includes 4 Cores (Administrative, Clinical, Imaging, and Pathology) and 4 Projects. Project 1 (Reed & Jagust) will use amyloid imaging (Pittsburgh Imaging B [PIB] compound) to identify in vivo a cohort of subjects representing the full spectrum of AS, with minimal AD pathology. Project 2 (Weiner, DeCarli, and Singh) will determine the extent to which arteriosclerosis (AS) is associated with changes of brain perfusion and volume and integrity of gray matter (GM) and white matter (WM) and the extent to which these associations relate to AD- vs. CVD-pathology. .Project 6 (Zarow & Vinters) seeks to improve the clinical diagnosis of hippocampal sclerosis and to clarify its pathogenesis. Project 7 (Chui & Mungas) will test the overarching hypothesis using data obtained in the Clinical, Imaging, and Pathology Cores.

描述（由申请人提供）： 这项竞争性更新应用的首要目标是研究动脉硬化（AS）对大脑结构和功能的多效性影响，无论是单独还是与阿尔茨海默病（AD）相结合。我们提出了一个前瞻性的，纵向研究的方便样本（231当前+276新= 507名受试者），选择使用FCRP心血管风险特征（FCRP），以确保代表性的主题范围从轻微到严重的动脉硬化（AS）。PPG包括4个核心（管理、临床、成像和病理）和4个项目。项目1（Reed & Jagust）将使用淀粉样蛋白成像（匹兹堡成像B [PI B]化合物）在体内鉴定代表AS全谱的一组受试者，具有最小的AD病理。项目2（Weiner、DeCarli和Singh）将确定动脉硬化（AS）与脑灌注和灰质（GM）和白色物质（WM）体积和完整性变化的相关程度，以及这些相关性与AD和CVD病理学的相关程度。项目6（Zarow & Vinters）寻求改善海马硬化的临床诊断并阐明其发病机制。项目7（Chui & Mungas）将使用临床、成像和病理核心中获得的数据来测试总体假设。