Effects of BPA and Phthalates on Adiposity and Metabolic Risk Factors in Women
BPA 和邻苯二甲酸盐对女性肥胖和代谢危险因素的影响
基本信息
- 批准号:8618462
- 负责人:
- 金额:$ 11.92万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-02-01 至 2016-01-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdultAgeAnalytical ChemistryAnimalsAreaAwardBirthBlood PressureBody WeightChemicalsChildCholesterolCohort StudiesConsumptionDNA MethylationDataDevelopmentDiabetes MellitusDietDietary FatsDiseaseDoseEndocrine DisruptorsEnvironmentEnvironmental EpidemiologyEnvironmental ExposureEnvironmental HealthEnvironmental Risk FactorEpidemicEpidemiologic StudiesEpidemiologyEpigenetic ProcessEstrogen Receptor alphaExposure toFastingFoundationsFundingGenesGlucocorticoid ReceptorGoalsGrowthGrowth and Development functionHealthHigh Density Lipoprotein CholesterolHomeostasisHormonalHumanHypertriglyceridemiaIn VitroInsulin ResistanceIntakeInterdisciplinary StudyKnowledgeLaboratoriesLeptinLifeLipidsMaternal ExposureMaternal HealthMeasurementMeasuresMediator of activation proteinMentorsMetabolicMetabolic DiseasesMetabolic stressMetabolismMexicoMolecular BiologyMorbidity - disease rateMothersNatureNeurocognitiveNuclear Receptor GeneNutrientNutritionalObesityOther GeneticsOutcomePPAR gammaParentsPathway interactionsPeroxisome Proliferator-Activated ReceptorsPhasePhenotypePhysical activityPhysiologicalPlaguePlasmaPlayPostpartum PeriodPregnancyPrevalencePreventive MedicinePublic HealthPublicationsReadingReproductionResearchResearch ActivityResearch TrainingRisk FactorsRoleRotationSelf CareSocial EnvironmentSocial SciencesSpecific qualifier valueStagingStressSystemTestingTimeToxicologyTrainingTraining ActivityUrineWeightWomanWomen&aposs Healthadipokinesadiponectinbasebisphenol Acardiovascular disorder riskcareercareer developmentcohortearly life exposureenergy balancefollow-upglucose metabolismhuman studyinnovationlipid metabolismmedical schoolsmeetingsmortalitymother nutritionnutritionnutritional epidemiologyobesity in childrenphthalatesprenatalprogramsprospectivepublic health relevancereproductivereproductive epidemiologyresponsesaturated fatskillsstressor
项目摘要
DESCRIPTION (provided by applicant):
Obesity and related cardio-metabolic health disorders are leading causes of morbidity and mortality among women. The rapidly increasing worldwide prevalence of these disorders suggests that risk factors other than genetics, diet, and physical activity are involved. Environmental factors, such as endocrine disrupting chemicals (EDC), likely play an important role in modifying the response to dietary nutrients. Bisphenol A (BPA) and phthalates are examples of EDCs that are ubiquitous in our environment and may contribute to the development of metabolic disorders by interfering with glucose and lipid metabolism and energy balance. Much of the current research focuses on exposures during stages of early life growth and development. However, pregnancy is a relatively unappreciated sensitive life stage in adults that is associated with numerous physiologic changes, which may have lasting consequences for women's health. Associations of exposures to BPA and phthalates during pregnancy and the development of cardio-metabolic health indicators in women during the long-term postpartum period have not yet been investigated. The candidate has a strong foundation in the methodological and analytical skills related to nutritional and reproductive epidemiology. The intent of this application is in seeking a Pathway to Independence Award to gain the additional training needed to accomplish the following long-term career goal: to establish an independent research program to investigate the intersection of environmental and nutritional factors related to disease development, progression, and treatment. The training component of this project will be based in the Department of Preventive Medicine (DPM) at Mount Sinai School of Medicine. The DPM is internationally renowned for excellence in innovative, interdisciplinary research in public health, epidemiology, environmental health, and social sciences. The mentors, Drs. Susan Teitelbaum and Robert Wright, are experts in the field of environmental health and the advisory team, Drs. Mary Wolff, Andrea Baccarelli, Brent Coull, and Mara Tellez-Rojo, possesses complementary areas of expertise to address training and research goals. The proposed training plan includes formal coursework, directed readings, attendance to scholarly seminars and meetings, and mentored career development activities, as well as rotations in Dr. Wright's molecular biology and analytical chemistry laboratories. From this training, the idea is to gain knowledge and skills related to environmental health and EDCs, toxicology, epigenetics, and advanced statistical analysis, which will be applied during the research component of this project. The proposed research will determine whether exposures to BPA and phthalates during pregnancy and the postpartum are associated with the development of adiposity and cardio-metabolic health indicators in women. This research will be conducted by leveraging data regarding maternal exposures and health outcomes collected from the Programming Research in Obesity, Growth, Environment, and Social Stressors (PROGRESS) study (R01 ES013744 and R01 ES021357 BPA, Phthalates & Stress: Mechanisms and Interactions for Childhood Obesity), a prospective birth cohort in Mexico. The following aims will be accomplished: 1) Determine whether exposures to BPA and phthalates in pregnancy and the postpartum are associated with the development of adiposity and cardio-metabolic health indicators in adult women up to 7 years postpartum. 2) Determine whether exposure to BPA and phthalates modifies the association of dietary fat with the development of adiposity and cardio-metabolic health indicators. 3) Determine the role of DNA methylation as a mediator of the associations of BPA and phthalates and the development of adiposity and cardio-metabolic health indicators. DNA methylation of nuclear receptor genes that are involved in body weight homeostasis will be measured: glucocorticoid receptor, ER¿, and PPAR?. The training and research activities will result in scientific presentations and publications, and will prepare me to successfully compete for R01 funding during the R00 phase.
描述(由申请人提供):
肥胖和相关的心脏代谢健康障碍是妇女发病率和死亡率的主要原因。这些疾病在全球范围内的迅速流行表明,除了遗传、饮食和体力活动之外,还有其他危险因素参与其中。环境因素,如内分泌干扰物(EDC),可能在改变对饮食营养的反应方面发挥重要作用。双酚A(BPA)和邻苯二甲酸酯是在我们的环境中普遍存在的内分泌细胞的例子,它们可能通过干扰糖、脂代谢和能量平衡而导致代谢紊乱的发展。目前的大部分研究集中在生命早期、生长和发育阶段的暴露。然而,在成年人中,怀孕是一个相对未被认识到的敏感生命阶段,与许多生理变化有关,这可能会对女性的健康产生持久的影响。怀孕期间暴露于双酚A和邻苯二甲酸盐与妇女在产后长期内心脏代谢健康指标的发展之间的关系尚未被调查。候选人在与营养和生殖流行病学相关的方法和分析技能方面有很强的基础。本申请的目的是寻求获得独立之路奖,以获得完成以下长期职业目标所需的额外培训:建立一个独立的研究计划,调查与疾病发展、进展和治疗相关的环境和营养因素的交集。该项目的培训部分将设在西奈山医学院预防医学系。DPM在公共卫生、流行病学、环境健康和社会科学领域的创新、跨学科研究方面的卓越表现享誉国际。导师Susan Teitelbaum博士和Robert Wright博士是环境健康领域的专家,顾问团队Mary Wolff博士、Andrea Baccarelli博士、Brent Coull博士和Mara Tellez-Rojo博士拥有互补的专业知识领域,以满足培训和研究目标。拟议的培训计划包括正式的课程作业、定向阅读、参加学术研讨会和会议、指导职业发展活动,以及在赖特博士的分子生物学和分析化学实验室轮换。从这次培训中,我们的想法是获得与环境健康和环境控制、毒理学、表观遗传学和高级统计分析有关的知识和技能,这些知识和技能将在本项目的研究部分中应用。这项拟议的研究将确定怀孕期间和产后暴露于双酚A和邻苯二甲酸酯是否与女性肥胖和心脏代谢健康指标的发展有关。这项研究将利用从肥胖、生长、环境和社会压力(PROCESS)规划研究(PROCESS)研究(R01 ES013744和R01 ES021357 BPA,邻苯二甲酸盐和压力:儿童肥胖的机制和相互作用)收集的关于母亲暴露和健康结果的数据进行,这是墨西哥的一项预期出生队列。将实现以下目标:1)确定怀孕和产后暴露于双酚A和邻苯二甲酸盐是否与成年妇女产后7年内肥胖和心脏代谢健康指标的发展有关。2)确定暴露于双酚A和邻苯二甲酸盐是否会改变膳食脂肪与肥胖和心脏代谢健康指标的关系。3)确定DNA甲基化在双酚A和邻苯二甲酸酯之间的关系以及肥胖和心脏代谢健康指标的发展中所起的中介作用。将测量参与体重动态平衡的核受体基因的DNA甲基化:糖皮质激素受体、ER和PPAR?培训和研究活动将产生科学报告和出版物,并将为我在R00阶段成功争取R01资金做好准备。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANDREA L DEIERLEIN其他文献
ANDREA L DEIERLEIN的其他文献
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{{ truncateString('ANDREA L DEIERLEIN', 18)}}的其他基金
Harnessing Patient Generated Data to Find Causes and Effects of Diet in Pregnancy
利用患者生成的数据来查找怀孕期间饮食的原因和影响
- 批准号:
10402359 - 财政年份:2019
- 资助金额:
$ 11.92万 - 项目类别:
Harnessing Patient Generated Data to Find Causes and Effects of Diet in Pregnancy
利用患者生成的数据来查找怀孕期间饮食的原因和影响
- 批准号:
9980490 - 财政年份:2019
- 资助金额:
$ 11.92万 - 项目类别:
Harnessing Patient Generated Data to Find Causes and Effects of Diet in Pregnancy
利用患者生成的数据来查找怀孕期间饮食的原因和影响
- 批准号:
9914388 - 财政年份:2019
- 资助金额:
$ 11.92万 - 项目类别:
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