CORE--Data Management and Statistic

核心--数据管理与统计

• 批准号: 8279277
• 负责人: HOWARD F. ANDREWS
• 金额: $ 12.4万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8279277
• 关键词: Acute; Adrenergic Receptor; Age; Asthma; Biological Markers; Biometry; Birth; Child; Childhood Asthma; Clinical; Computer software; Confidentiality; Consultations; Data; Data Analyses; Data Base Management; Data Files; Data Quality; Data Security; Data Sources; Data Storage and Retrieval; Databases; Documentation; Ensure; Environmental Exposure; Environmental Health; Epigenetic Process; Health; Individual; Information Systems; Knowledge; Laboratories; Leadership; Measurement; Measures; Modification; Mothers; Outcome; Pathogenesis; Policies; Predisposition; Procedures; Protocols documentation; Public Health Applications Research; Publications; Questionnaires; Relative (related person); Research; Research Design; Research Infrastructure; Research Project Grants; Resources; Role; Secure; Statistical Data Interpretation; Testing; Time; Translations; Update; Work; base; cohort; cost; data management; data sharing; database design; design; electronic data; high standard; improved; meetings; pollutant; prenatal; programs; quality assurance; relational database; repository; response; statistics; trafficking

The Data Management and Biostatistics (DMS) Core will maintain a centralized, integrated database containing all exposure, biomarker, asthma, and other health-related questionnaire data collected in the past eight years on the Columbia Center for Child Environmental Health (CCCEH) northern Manhattan cohort of 700+ children and mothers, including the extensive additional information that will be acquired about these children under the proposed DISCOVER project. The DMS Core will serve as a central resource for high quality data management, cohort tracking and coordination, statistical planning, data analysis and publication review for all four projects. The DMS Core will also provide technical support for the translational and data sharing initiatives organized by the Administrative Core. The CCCEH northern Manhattan cohort database currently includes information from birth through age 5 from multiple data sources, including repeated measurement of exposures that will be extended under the DISCOVER project, as well as many new measures that will be collected on cohort children for the first time. In order to ensure continuity of observation of the cohort, the DMS Core will work closely with the Administrative Core by providing a state-of-the-art interactive tracking information system separate from the research database that allows direct, secure access to extensive contact information and indicators of information types collected in previous followups, and allows direct updating of current information. In order to ensure the highest quality of stored cohort research information in the DISCOVER initiative, and to facilitate the availability of cohort data for statistical analysis and translational activities, the DMS core will: 1) maintain a comprehensive quality assurance program; 2) establish standardized protocols for electronic data submission from participating projects and laboratories; 3) use SIR2002 relational database management software to create a self-documenting central database and to quickly produce analytic-ready statistical files with appropriate content, format and internal documentation for statistical analysis; 4) establish mechanisms for coordinating all project publication efforts and publication review.

数据管理和生物统计（DMS）核心将维护一个集中的综合数据库，其中包含过去八年中收集的哥伦比亚儿童环境健康中心（CCCEH）北方曼哈顿曼哈顿700多名儿童和母亲队列的所有暴露、生物标志物、哮喘和其他健康相关问卷数据，包括在拟议的DISCOVER项目下将获得的关于这些儿童的广泛的额外信息。DMS核心将作为高质量数据管理、队列跟踪和协调、统计规划、数据分析和发布的中心资源 对四个项目进行审查。目的地管理系统核心还将为行政核心组织的翻译和数据共享举措提供技术支持。 CCCEH北方曼哈顿队列数据库目前包括来自多个数据源的从出生到5岁的信息，包括将在DISCOVER项目下扩展的暴露的重复测量，以及将首次收集的队列儿童的许多新测量。 为了确保队列观察的连续性，数据管理系统核心将与行政核心密切合作，提供一个独立于研究数据库的最先进的互动跟踪信息系统，使人们能够直接、安全地获取广泛的联系信息和以往后续行动中收集的信息类型指标，并直接更新当前信息。 为了确保DISCOVER计划中存储的队列研究信息的最高质量，并促进队列数据用于统计分析和翻译活动的可用性，DMS核心将：1）维护全面的质量保证计划; 2）为参与项目和实验室的电子数据提交建立标准化协议; 3）使用SIR 2002关系数据库管理软件，建立一个自我记录的中央数据库，并迅速生成具有适当内容、格式和内部文件的可供分析的统计文件，以供统计分析使用; 建立协调所有项目出版工作和出版物审查的机制。