CORE--DATA MANAGEMENT AND STATISTICS CORE

核心--数据管理与统计核心

• 批准号: 6932708
• 负责人: HOWARD F. ANDREWS
• 金额: $ 11.75万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6932708
• 关键词: Alzheimer' s disease; Internet; biomedical facility; data collection methodology /evaluation; data management; data quality /integrity; epidemiology; medical outreach /case finding; neuropathology; statistics /biometry

The Database Management and Statistics Core (DMS) will formalize central data management and biostatistical resources and functions that have existed within the Clinical Core since the inception of the Columbia ADRC in 1989. The new DMS Core will be composed of two component and well-coordinated arms, one for biostatistical/epidemiological and the other for data management functions. The Data Management Component will continue to manage a large, highly structured relational database currently containing all clinical evaluation and neuropathological examination data on a large cohort of over 3,800 subjects. In the proposed funding period the Database Management Component will integrate data collected from the new Isabella Home Care (IHC) cohort into the central database, will continue to provide data files required by the National Alzheimer's Coordinating Center (NACC) in a timely manner, and will serve as a central resource for data, epidemiological and statistical resources to the projects described in this application, as well as to approved collaborations with external investigators and NACC-initiated research projects. The Statistics and Epidemiology Component will work closely with the investigators of each project to design and implement statistical analyses, and to assist in the preparation and review of manuscripts for publication. The Statistics and Epidemiology Component will also be a resource for collaborative NACC projects and participate in the design and analysis of collaborative ad hoc research efforts with external and internal investigators. Staff of both components of the DMS Core will continue to participate in weekly, scheduled meetings with leaders of the other cores and projects to review and discuss all data-related issues, including: 1) recruitment and followup of the new IHC cohort; 2) continued recruitment and followup of Memory Clinics subjects who have consented to brain autopsy; 3) coordination of data flow between the clinical and neuropathological cores, and 4) the needs of the projects and collaborators for data, statistical planning and data analysis.

数据库管理和统计核心（DMS）将正式确定自1989年哥伦比亚ADRC成立以来临床核心中存在的中央数据管理和生物统计资源和功能。新的目的地管理系统核心将由两个组成部分和协调良好的部门组成，一个负责生物统计/流行病学，另一个负责数据管理职能。数据管理部分将继续管理一个大型、高度结构化的关系数据库，该数据库目前包含3 800多名受试者的所有临床评价和神经病理学检查数据。在拟议的资助期内，数据库管理组件将把从新的Isabella家庭护理（IHC）队列收集的数据整合到中央数据库中，并将继续提供数据文件 国家阿尔茨海默氏症协调中心（NACC）要求及时提供，并将作为本申请中描述的项目的数据、流行病学和统计资源的中心资源，以及与外部研究者和NACC发起的研究项目的批准合作。统计和流行病学部分将与每个项目的调查人员密切合作，设计和执行统计分析，并协助编写和审查供出版的手稿。统计和流行病学部分也将是NACC合作项目的一个资源，并参与设计和分析与外部和内部的合作特设研究工作。 investigators. DMS核心的两个组成部分的工作人员将继续参加与其他核心和项目领导人的每周定期会议，以审查和讨论所有数据相关问题，包括：1）新IHC队列的招募和随访; 2）继续招募和随访同意进行脑尸检的记忆诊所受试者; 3）临床和神经病理学核心之间的数据流协调，以及4）项目和合作者对数据、统计规划和数据分析的需求。