BIOSTATISTICAL AND DATA MANAGEMENT CORE

所有SPOTRIAS项目的数据在过去五年里一直在管理，并将继续管理 在业务数据管理核心负责人霍华德·安德鲁斯博士的监督下设计和维护的单一哥伦比亚SPOTRIAS综合数据库在续订期间进行管理。安德鲁斯博士也是哥伦比亚大学梅尔曼公共卫生学院(MSPH)数据协调中心(DCC)的主任，该学院隶属于MSPH生物统计学系，也为哥伦比亚大学的附属机构纽约州精神病学研究所(NYSPl)提供服务。SPOTRIAS数据库驻留在NYSPl的IT员工维护的物理和电子安全的服务器集群上。核心B数据库经理Greg Neils先生与Andrews博士和SPOTRIAS调查人员和协调员协商，并在核心B程序员David Merie先生的协助下，设计和实施了哥伦比亚SPOTRIAS综合SPOTRIAS数据库以及过去五年纳入该数据库的主要功能。在MSPH生物统计部担任初级职务的高级统计师白明熙博士和张健博士传统上负责神经内科临床试验的统计咨询和数据分析，并在过去五年领导SPOTRIAS统计部分，并将在拟议的续期内继续这样做。埃里克·扎拉恩博士 神经学研究所副研究科学家，是神经成像数据分析方面的专家，包括统计参数图和动态因果建模。白博士将全面领导统计部分，即值得的统计设计咨询(项目3，中风中的出院教育策略，以鼓励减少血管事件)，并将监督数据分析师玛格丽特·多伊尔的工作，她负责项目1和项目2的分析。张博士是NeuSTART(项目1，急性恢复试验的他汀类药物神经保护疗法)的高级统计师，扎拉恩博士是项目2，急性中风后恢复：多模式调查的高级统计师。

Data for all SPOTRIAS projects has been managed for the previous five years, and will continue to be managed in the renewal period within a single integrated Columbia SPOTRIAS database designed and maintained under the oversight of BDM core leader Dr. Howard Andrews. Dr. Andrews is also director of the Data Coordinating Center (DCC) at the Columbia Mailman School of Public Health (MSPH), which is affiliated with the MSPH Biostatistics Department and which also serves the New York State Psychiatric Institute (NYSPl), a Columbia affiliate. The SPOTRIAS database resides on a physically and electronically secure server cluster maintained by the IT staff of NYSPl. Mr. Greg Neils, the Core B database manager, in consultation with Dr. Andrews and SPOTRIAS investigators and coordinators, and with the assistance of the Core B programmer, Mr. David Merie, designed and implemented the Columbia SPOTRIAS integrated SPOTRIAS database and the key functionalities that have been incorporated into the database over the past five years. Senior statisticians with primary appointments in the MSPH Biostatistics Department, Dr. Myunghee Paik and Dr. Ken Cheung, have traditionally overseen statistical consultation and data analysis for Clinical Trials in the Department of Neurology, have provided leadership for the SPOTRIAS statistical component for the past five years, and will continue to do so in the proposed renewal period. Dr. Eric Zarahn, Associate Research Scientist at the Neurological Institute, is an expert in neuroimaging data analysis, including Statistical Parametric Mapping and Dynamic Causal Modeling. Dr. Paik will provide overall leadership of the Statistics Component, statistical design consultation to DESERVE (Project 3, Discharge Educational Strategies in Stroke to Encourage Reduction of Vascular Events), and will oversee the work of the data analyst, Margaret Doyle, who conducts the analyses for Projects 1 and 2. Dr. Cheung is the senior statistician for NeuSTART (Project 1, Neuroprotection with Statin Therapy for Acute Recovery Trial), and Dr. Zarahn is senior statistician for Project 2, Recovery after Acute Stroke: a Multi-modal Investigation.