METABOLIC RESPONSE TO WESTERN VS INDIGENOUS DIETS IN HISPANIC WOMEN

摘要：本研究旨在了解西班牙裔女性饮食模式与肥胖风险之间的关系。这是健康差异领域的一个重要问题，因为美国近80%的西班牙裔妇女超重或肥胖，肥胖增加了许多慢性疾病的风险，包括乳腺癌。该项目的总体目标是测试西班牙裔妇女对西方和墨西哥土著饮食的代谢反应。我们还将研究祖先遗传变异是否介导了对每种饮食的反应。我们假设，西方饮食模式的生物学反应产生了有利于脂肪沉积的有害代谢谱，从而导致不良健康事件的风险增加，包括乳腺癌的风险增加。相反，我们假设对墨西哥土著饮食的生理反应将产生有利的代谢剖面。我们进一步假设，遗传祖先介导了这种对西方饮食模式的生物学反应。我们的主要目的是：(1)在一项随机交叉实验喂养研究中测试50名居住在大西雅图地区的第一代和第二代西班牙裔妇女对墨西哥土著饮食和西方饮食的代谢反应。代谢反应将通过在每个饲喂期前后评估以下生物标志物的血液浓度来测量：胰岛素、葡萄糖、IGFI、IGFBP3、瘦素、脂联素、IL-6、CRP和SAA；(2)研究遗传特征是否介导了对每种被测饮食的代谢反应。作为次要施舍，我们将在每个饮食测试期间检查饥饿和饱腹感的测量以及肥胖的遗传预测因素。该项目将为了解西班牙裔女性肥胖的病因提供重要数据，可用于设计有效的预防方案。

Abstract: This proposal focuses on understanding the relationship between dietary patterns and risk of obesity in Hispanic women. This is an important issue in the realm of health disparities because neariy 80% of Hispanic women in the United States are ovenweight or obese and obesity increases risk for numerous chronic diseases, including breast cancer. The overall goal of this project Is to test the metabolic response to Western -and Indigenous Mexican diets in Hispanic women. We will also investigate whether ancestral genetic variation mediates the response to each diet. We hypothesize that the biological response to a Western dietary pattern produces detrimental metabolic profiles favoring adipose deposition, which leads to increased risk of adverse health events, including increased risk of breast cancer. Conversely, we hypothesize that the physiologic response to an Indigenous Mexican diet will produce a favorable metabolic profile. We further hypothesize that genetic ancestry mediates this biological response to a Western dietary pattern. Our primary aims are: (1) To test in a randomized cross-over experimental feeding study the metabolic response to an Indigenous Mexican diet vs. a Western diet in 50 first and second generation Hispanic women living in the greater Seattle area. The metabolic response will be measured by blood concentrations ofthe following biomarkers assessed before and after each feeding period: insulin, glucose, IGFI, IGFBP3, leptin, adiponectin, IL-6, CRP and SAA; and (2) To investigate whether genetic characteristics, as assessed with Ancestry Informative Markers, mediate the metabolic response to each tested diet. As secondary alms we will examine measures of hunger and satiety during each diet test period and genetic predictors of adiposity. This project will provide important data for understanding the etiology of obesity in i-lispanic women, which can be used to design effective programs for prevention.