Eastern Cooperative Oncology Group (Main Institution)

描述(由申请人提供)：匹兹堡大学癌症研究所(UPCI)成立于1985年，自那以来的23年里，已经积累了400多名基础和临床研究人员，他们拥有与ECOG的许多疾病和模式委员会相关的广泛的基础和临床专业知识。东部合作肿瘤学小组(ECOG)是UPCI成人实体肿瘤多模式临床研究的主要外部焦点。UPCI的总部设在匹兹堡大学医学中心(UPMC)的医院，该医疗系统由UPMC长老会(PUH)、UPMC Montefiore(MUH)、眼耳医院和研究所、UPMC Shadyside医院、西方精神科医院和诊所、Falk诊所和Magee妇女医院组成。2002年，UPMC癌症中心成立，其中包括超过45个地点，作为UPCI全职和临床教职员工的业务基地，他们活跃在匹兹堡和整个地区的ECOG。这些医院包括UPMC Shadyside、UPMC Bedford Memory、UPMC Braddock、UPMC Horizon-Greenville和Shenango Valley、UPMC Lee Region、UPMC McKeesport、UPMC西北富兰克林和石油城、UPMC Passaant、Cranberry、UPMC Southside、匹兹堡儿童医院、UPMC圣玛格丽特医院、UPMC Mercy、Magee妇女医院、比弗谷、拉特罗布地区医院、遗产谷医疗系统、Westmorland医院、Jameson Health System、Jefferson区域医疗中心、纪念医疗中心、华盛顿医院、Union town医院、Frick医院以及UPMC康复医院。这些设施提供了一个垃圾区，从西弗吉尼亚州延伸到俄亥俄州和纽约州，横跨宾夕法尼亚州西部。奥克兰退伍军人管理医疗中心是ECOG的联盟成员，为VA系统的患者提供ECOG研究。UPMC于1993年将住院患者的临床设施迁至UMH，并于2003年将其迁至Hillman癌症中心-UPMC Shadyside医学中心，提供全方位服务的住院肿瘤学、外科肿瘤学和血液学/BMT，以及位于门诊Hillman癌症中心门诊护理设施的卫星临床翻译科学研究所(CTSI)。在这项CTSI上正在进行一系列带有实验室组成部分的ECOG研究，为ECOG试验中患者的方案治疗提供支持，超出了第三方支付者覆盖范围的范围。UPCI的基础癌症研究空间已整合到2002年建成的希尔曼癌症中心研究展馆中，提供与门诊和住院设施相邻的最先进的研究实验室。与ECOG直接相关的机构包括作为ECOG核心免疫监测实验室的临床免疫监测实验室(IMCPL)、血清和组织库以及流式细胞仪FACS/杂交瘤设施。分别位于UPMC校园内的是结晶学、肽合成和寡核苷酸合成设施。临床研究服务部现在位于希尔曼癌症中心库珀门诊展馆，而生物统计办公室位于斯特林大楼，距离奥克兰校区更近几个街区。UPCI和UPMC已经发展成为矩阵组织，其中血液学/肿瘤学、外科肿瘤学和放射肿瘤学的传统学术部门和部门按照以疾病为导向的路线进行配置，以促进以疾病为导向的跨学科和医疗方案的增长和发展。 相关性：东部合作肿瘤学小组(ECOG)是UPCI成人实体肿瘤多模式临床研究的主要外部焦点。UPCI总部设在匹兹堡大学医学中心(UPMC)的医院。

DESCRIPTION (provided by applicant): The University of Pittsburgh Cancer Institute (UPCI) was formed in 1985, and over the twenty-three years since then has amassed a cadre of more than 400 basic and clinical investigators with broad basic and clinical expertise that relates to the ECOG in relation to many of its disease and modality committees. The Eastern Cooperative Oncology Group (ECOG) is the major extramural focus of multi-modal clinical investigations in adult solid tumors of the UPCI. UPCI is based in the hospitals of the University of Pittsburgh Medical Center (UPMC), a health system consisting of UPMC Presbyterian (PUH), UPMC Montefiore (MUH), the Eye and Ear Hospital and Institute, UPMC Shadyside Hospital, Western Psychiatric Hospital and Clinic, Falk Clinic, and the Magee Women's Hospital. In 2002, The UPMC Cancer Centers were formed, including a broad array of more than 45 locations that serve as the base of operations for full-time and clinical faculty of the UPCI who are active in ECOG within Pittsburgh and across the region. These include UPMC Shadyside, UPMC Bedford Memorial, UPMC Braddock, UPMC Horizon-Greenville and Shenango Valley, UPMC Lee Regional, UPMC McKeesport, UPMC Northwest Franklin and Oil City, UPMC Passavant, Cranberry, UPMC Southside, Children's Hospital of Pittsburgh, UPMC St. Margaret's, UPMC Mercy, Magee Women's Hospital, Beaver Valley, Latrobe Area Hospital, Heritage Valley Health System, Westmorland Hospital, Jameson Health System, Jefferson Regional Medical Center, Memorial Medical Center, The Washington Hospital, Uniontown Hospital and Frick Hospital as well as the UPMC Rehabilitation Hospital. These facilities provide for a cachement area that extends across Western Pennsylvania from W. Virginia to Ohio and New York State. The Oakland Veterans Administration Medical Center is a consortium member of ECOG, affording access to ECOG studies for patients of the VA system. UPMC relocated inpatient UPCI clinical facilities to MUH in 1993, and to the Hillman Cancer Center - UPMC Shadyside Medical Center in 2003, with full service inpatient Medical Oncology, Surgical Oncology, and Hematology/BMT as well as a satellite Clinical Translational Science Institute (CTSI) in the outpatient Hillman Cancer Center Ambulatory Care Facility. A range of ECOG studies with laboratory components are being conducted on this CTSI, providing support for protocol therapy of patients on ECOG trials beyond what would be possible with third party payer coverage. The basic cancer research space of UPCI has been consolidated in the Hillman Cancer Center Research Pavilion that was completed in 2002, offering state-of-the-art research laboratories contiguous with the outpatient and inpatient facilities. Those that relate directly to ECOG include the Clinical Immunologic Monitoring Laboratory (IMCPL) which serves as the Core Immunological Monitoring Laboratory for ECOG, the Serum and Tissue Bank, and Flow Cytometry FACS/Hybridoma facilities. Separately located on the campus of the UPMC are Crystallography, Peptide Synthesis, and Oligonucleotide Synthesis facilities. The Clinical Research Services are now located in the Hillman Cancer Center Cooper Ambulatory Pavilion, while the Biostatistical Office is located at the Sterling Building several blocks closer to the Oakland Campus. UPCI and UPMC have developed as matrix organizations in which the traditional academic departments and divisions of Hematology/Oncology, Surgical Oncology, and Radiation Oncology are configured along disease-oriented lines to facilitate the growth and development of interdisciplinary disease-oriented and modality programs. RELEVANCE: The Eastern Cooperative Oncology Group (ECOG) is the major extramural focus of multi-modal clinical Investigations In adult solid tumors of the UPCI. UPCI is based in the hospitals of the University of Pittsburgh Medical Center (UPMC).