Cell Biologic approaches to Diabetes Research

糖尿病研究的细胞生物学方法

• 批准号: 7850377
• 负责人: MICHAEL L. MCDANIEL
• 金额: $ 22.47万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7850377
• 关键词: Cells; Diabetes Mellitus; Research

DESCRIPTION (provided by applicant): This renewal application for years 31-35 of a structured, basic research-oriented Diabetes Training Program consists of 14 faculty members to train Ph.D. scientists & physicians to investigate problems of Types 1 & 2 diabetes. Faculty number & composition has been trimmed to enhance research directly related to diabetes including: 1) insulin secretion & (-cell proliferation, 2) development of endodermal lineages including (-cells, 3) processing & presentation of antigens by histocompatibility molecules in Type 1 diabetes, 4) immune tolerance & autoimmunity in Type 1 diabetes, 5) KATP channels & neonatal diabetes, 6) Ca¿+-independent phospholipase A2 & (-cells 7) insulin resistance/diabetes in adult HIV disease, 8) diabetic neuropathy, 9) glucose transporters & Type 2 diabetes , 10) lipid synthesis, metabolism & vascular diseases in diabetes, 11) obesity, diabetes & nutrition, 12) diabetes-induced pregnancy loss & malformations. The mainstay of training is an independent research project in a mentor's laboratory & opportunities to collaborate with other mentors & basic scientists. The trainees & faculty actively participate by presenting their ongoing work at biweekly (-cell biology meetings. To broaden & strengthen their independent research projects, trainees also participate in weekly seminars on both basic & clinical issues in diabetes, endocrinology, metabolism and immunology. Trainees will present their research at national meetings, & career development will be enhanced by structured workshops in grant & manuscript writing and reviewing. All trainees will participate in "The Program for the Ethical and Responsible Conduct of Science & Scholarship". Trainees are generally recent graduates with PhD and/or MD degrees in areas of molecular biology & basic sciences & a commitment to research careers in diabetes and metabolic diseases. The duration of training is 3 years. Support is requested for 4 postdoctoral trainees. Our basic research-oriented postdoctoral training program complements & interacts with the Diabetes Research and Training Center, & a parallel clinically-oriented diabetes training program in the Department of Medicine. Washington University School of Medicine is an institution known for its excellence in basic & clinical diabetes research. Goals of this program are to provide postdoctoral trainees with research experience & skills necessary to gain extramural funding & career opportunities to develop into independent investigators with a career commitment to research & teaching in diabetes. PUBLIC HEALTH RELEVANCE: The consequences of the debilitating complications resulting from diabetes including increased incidence of stroke, cardiovascular disease, and peripheral neuropathy are staggering. It is critical that academic research institutions and the diabetes health profession actively train well-qualified research scientists and physicians in the prevention and treatment of this major health problem. The goal of this proposal is to train research scientists and physicians in the prevention and treatment of Types 1 & 2 diabetes.

描述（由申请人提供）：这是一个结构化的，以基础研究为导向的糖尿病培训计划的31-35年的更新申请，由14名教师组成，以培养博士。科学家和医生调查1型和2型糖尿病的问题。教师人数和组成已被削减，以加强直接相关的研究糖尿病，包括：1）胰岛素分泌和（-细胞增殖，2）内胚层谱系的发育，包括1型糖尿病中的组织相容性分子对抗原的加工和呈递，1型糖尿病中的免疫耐受和自身免疫，5）KATP通道和新生儿糖尿病，6）Ca？+-非依赖性磷脂酶A2和（-细胞7）成人HIV疾病中的胰岛素抵抗/糖尿病，8）糖尿病神经病变，9）葡萄糖转运蛋白和2型糖尿病，10）糖尿病中的脂质合成、代谢和血管疾病，11）肥胖、糖尿病和营养，12）糖尿病引起的妊娠丢失和畸形。培训的主要内容是在导师的实验室进行独立的研究项目，并有机会与其他导师和基础科学家合作。学员和教师积极参与，在每两周一次的细胞生物学会议上介绍他们正在进行的工作。为了扩大和加强他们的独立研究项目，学员还参加每周一次的糖尿病，内分泌学，代谢和免疫学基础和临床问题研讨会。学员将在国家会议上展示他们的研究，职业发展将通过赠款和手稿写作和审查的结构化研讨会得到加强。所有学员将参加“科学与奖学金的道德和负责任行为计划”。 受训人员通常是分子生物学和基础科学领域的博士和/或医学博士学位的应届毕业生，并致力于糖尿病和代谢疾病的研究事业。培训时间为3年。需要为4名博士后学员提供支助。我们的基础研究为导向的博士后培训计划补充和互动与糖尿病研究和培训中心，以及在医学系平行临床为导向的糖尿病培训计划。华盛顿大学医学院是一所以基础和临床糖尿病研究而闻名的机构。该计划的目标是为博士后学员提供必要的研究经验和技能，以获得校外资金和职业机会，发展成为独立的研究人员，致力于糖尿病的研究和教学。 公共卫生相关性：由糖尿病引起的衰弱性并发症的后果，包括中风、心血管疾病和周围神经病变的发病率增加，是惊人的。至关重要的是，学术研究机构和糖尿病卫生专业积极培训合格的研究科学家和医生，以预防和治疗这一重大健康问题。该提案的目标是培训研究科学家和医生预防和治疗1型和2型糖尿病。