Childhood Infection Research Program

申请者描述(由申请人提供)：本申请请求支持Vanderbilt“儿童感染研究计划”(CHIRP)，这是一个新的博士后科学家培训计划，旨在为儿科传染病临床研究员和博士后科学家提供基础和临床-翻译科学方面的培训。Vanderbilt Chirp的目标是培训和促进致力于与儿童感染相关的研究的未来学术生物医学科学领导者的职业生涯。范德比尔特没有专注于儿童感染的培训计划，CHIRP为未来的基础和临床研究人员建立了一个独特的培训利基市场。本申请提出了一项创新计划，该计划同时使用了1)指导研究培训和2)“同行指导和培训”(PMT)，这是一项新的计划，将与临床研究员和博士后科学家合作，促进跨学科(医学研究生、研究生医学)培训和经验。Chirp-PMT培训将培养对临床传染病有培训和深入了解的基础科学家，以及对微生物发病的基本机制有广泛知识的临床翻译研究人员。培训计划的关键要素将是使用主要导师、个人发展计划和负责定期审查科学进步和职业发展的指导委员会。召集起来的教师导师小组是根据已证明的卓越研究以及在培养博士后科学家和临床研究员从事研究工作方面的长期成功而挑选出来的。调查人员在儿科、内科、微生物学和免疫学以及预防医学系担任初级职务，总共持有约3400万美元的外部资金。负责任地进行研究的培训将纳入整个培训学期，并将建立新兴领域的能力，如高度生物安全遏制、两用研究和国际合作中的研究伦理。申请者集中招聘MD和MD/PhD儿科传染病同事候选人，以及申请单独实验室的博士和MD/博士后科学家，并通过Vanderbilt博士后事务办公室等新项目获得结果。招聘将侧重于临床研究员和博士后候选人，他们来自研究中代表性较低的群体。该提案要求每年为两名博士后实习生提供资助职位，在第一年之后的每一年里，该项目总共有四名实习生。CHIRP的目标是每年培养一名临床研究员和一名博士后科学家，并建立一批临床和博士后科学家，致力于整合教职员工和同行导师的研究文化和经验。对CHIRP的支持请求是基于申请者的实力、培训儿童感染科学家的特殊机会以及对儿童感染研究带头人的教育的机构承诺。相关性：该计划的广泛意义将通过受训者的学术成就和对基本疾病机制的发现以及与传染病的预防和治疗直接相关的转化-临床结果来实现。 公共卫生相关性：该申请提出了一个新的T32“儿童感染研究计划”(CHIRP)。该项目的目标是培养儿童微生物发病机制和传染病领域的博士后科学家。该申请提出了一项创新计划，允许联合培训临床ID研究员和博士后科学家，从而培养能够进行高影响力研究并培训下一代科学家的研究人员。

DESCRIPTION (provided by applicant): This application requests support for the Vanderbilt "Childhood Infections Research Program" (ChIRP) a new postdoctoral scientist training program in basic and clinical-translational science for MD and MD/PhD clinical fellows in Pediatric Infectious Diseases and PhD postdoctoral scientists. The goal of the Vanderbilt ChIRP is to train and foster the careers of future leaders in academic biomedical science who are committed to research relevant to infections of children. There is no training program at Vanderbilt focused on the childhood infections, and ChIRP establishes a unique training niche for future basic and clinical investigators. This application proposes an innovative program that uses both 1) mentored research training and 2) "Peer Mentoring and Training" (PMT), a novel program that will partner clinical fellows and postdoctoral scientists to facilitate cross-disciplinary (Med-Grad, Grad-Med) training and experience. ChIRP-PMT training will result in basic scientists with training and in-depth understanding of clinical infectious disease, as well as clinical-translational investigators with a broad knowledge of the basic mechanisms of microbial pathogenesis. Key elements of the training program will be the use of primary mentors, individual development plans, and mentoring committees charged with regular review of scientific progress and career development. The assembled group of faculty mentors has been selected based on demonstrated research excellence, as well as long-term success in training of postdoctoral scientists and clinical fellows for research careers. The investigators hold primary appointments in the Departments of Pediatrics, Medicine, Microbiology and Immunology, and Preventive Medicine and together hold ~$34 million in extramural funding. Training in responsible conduct of research will be incorporated throughout the training term and will establish competencies in emerging areas such as high-biosafety containment, dual-use research, and research ethics in international collaborations. The applicant pool results from recruiting efforts focused on MD and MD/PhD Pediatric Infectious Diseases Fellow candidates and from PhD and MD/PhD postdoctoral scientists who apply to individual labs and through novel programs such as the Vanderbilt Office of Postdoctoral Affairs. Recruiting will emphasize clinical fellows and postdoctoral candidates from groups underrepresented in research. The proposal requests funded positions for two postdoctoral trainees each year, with four trainees total in the program during each year after year 1. The goal of ChIRP is to train one clinical fellow and one postdoctoral scientist per year, and to establish a group of clinical and postdoctoral scientists committed to an integrated faculty-and-peer mentoring research culture and experience. This request for support for ChIRP is based on the strength of the applicant pool, exceptional opportunities for training scientists in childhood infections, and an institutional commitment to the education of leaders in research in childhood infections. Relevance: The broad significance of this program will be realized through the academic and scholarly accomplishments of the trainees and discoveries of basic disease mechanisms and translational-clinical results directly relevant prevention and treatment of infectious diseases. PUBLIC HEALTH RELEVANCE: This application proposes a new T32 "Childhood Infections Research Program" (ChIRP). The goal of the program is to train postdoctoral scientists in areas of microbial pathogenesis and infectious diseases of children. The application proposes an innovative program that allows joint training of clinical ID fellows and postdoctoral scientists, resulting in investigators who are able to perform high impact research and train the next generation of scientists.