Childhood Infection Research Program

描述（由申请人提供）：本申请要求支持范德比尔特“儿童感染研究计划”（ChIRP），这是一个新的博士后科学家培训计划，旨在为儿科传染病医学博士和医学博士/博士临床研究员和博士后科学家提供基础和临床转化科学。范德比尔特ChIRP的目标是培养和培养学术生物医学科学领域未来的领导者，他们致力于研究与儿童感染相关的问题。范德比尔特大学没有针对儿童感染的培训项目，而ChIRP为未来的基础和临床研究人员建立了一个独特的培训利基。这个申请提出了一个创新的项目，它使用了1)有指导的研究培训和2)“同伴指导和培训”（PMT），这是一个新颖的项目，将合作临床研究员和博士后科学家促进跨学科（医学研究生，研究生医学）的培训和经验。ChIRP-PMT培训将培养对临床传染病有深入了解的基础科学家，以及对微生物发病基本机制有广泛了解的临床转化研究人员。培训计划的关键要素将是使用主要导师、个人发展计划和负责定期审查科学进步和职业发展的指导委员会。教师导师团队的选择是基于卓越的研究成果，以及在培养博士后科学家和临床研究人员方面的长期成功。研究人员在儿科、医学、微生物学和免疫学以及预防医学等部门担任初级职位，总共拥有约3400万美元的校外资金。负责任的研究行为方面的培训将纳入整个培训学期，并将在诸如高生物安全性控制、双重用途研究和国际合作中的研究伦理等新兴领域建立能力。申请者主要来自于医学博士和医学博士/博士儿科传染病研究员候选人的招募工作，以及通过范德比尔特博士后事务办公室等新项目申请到个人实验室的博士和医学博士/博士后科学家。招聘将强调临床研究员和博士后候选人，他们来自研究中代表性不足的群体。该提案要求每年为两名博士后培训生提供资助职位，在第一年后每年有四名培训生参加该计划。ChIRP的目标是每年培养一名临床研究员和一名博士后科学家，并建立一组临床和博士后科学家，致力于整合教师和同行指导的研究文化和经验。这项对ChIRP的支持请求是基于申请人的实力，培训儿童感染科学家的特殊机会，以及对儿童感染研究领导者教育的机构承诺。相关性：通过学员的学术和学术成就以及与传染病预防和治疗直接相关的基本疾病机制和转化临床结果的发现，实现本项目的广泛意义。

DESCRIPTION (provided by applicant): This application requests support for the Vanderbilt "Childhood Infections Research Program" (ChIRP) a new postdoctoral scientist training program in basic and clinical-translational science for MD and MD/PhD clinical fellows in Pediatric Infectious Diseases and PhD postdoctoral scientists. The goal of the Vanderbilt ChIRP is to train and foster the careers of future leaders in academic biomedical science who are committed to research relevant to infections of children. There is no training program at Vanderbilt focused on the childhood infections, and ChIRP establishes a unique training niche for future basic and clinical investigators. This application proposes an innovative program that uses both 1) mentored research training and 2) "Peer Mentoring and Training" (PMT), a novel program that will partner clinical fellows and postdoctoral scientists to facilitate cross-disciplinary (Med-Grad, Grad-Med) training and experience. ChIRP-PMT training will result in basic scientists with training and in-depth understanding of clinical infectious disease, as well as clinical-translational investigators with a broad knowledge of the basic mechanisms of microbial pathogenesis. Key elements of the training program will be the use of primary mentors, individual development plans, and mentoring committees charged with regular review of scientific progress and career development. The assembled group of faculty mentors has been selected based on demonstrated research excellence, as well as long-term success in training of postdoctoral scientists and clinical fellows for research careers. The investigators hold primary appointments in the Departments of Pediatrics, Medicine, Microbiology and Immunology, and Preventive Medicine and together hold ~$34 million in extramural funding. Training in responsible conduct of research will be incorporated throughout the training term and will establish competencies in emerging areas such as high-biosafety containment, dual-use research, and research ethics in international collaborations. The applicant pool results from recruiting efforts focused on MD and MD/PhD Pediatric Infectious Diseases Fellow candidates and from PhD and MD/PhD postdoctoral scientists who apply to individual labs and through novel programs such as the Vanderbilt Office of Postdoctoral Affairs. Recruiting will emphasize clinical fellows and postdoctoral candidates from groups underrepresented in research. The proposal requests funded positions for two postdoctoral trainees each year, with four trainees total in the program during each year after year 1. The goal of ChIRP is to train one clinical fellow and one postdoctoral scientist per year, and to establish a group of clinical and postdoctoral scientists committed to an integrated faculty-and-peer mentoring research culture and experience. This request for support for ChIRP is based on the strength of the applicant pool, exceptional opportunities for training scientists in childhood infections, and an institutional commitment to the education of leaders in research in childhood infections. Relevance: The broad significance of this program will be realized through the academic and scholarly accomplishments of the trainees and discoveries of basic disease mechanisms and translational-clinical results directly relevant prevention and treatment of infectious diseases. PUBLIC HEALTH RELEVANCE: This application proposes a new T32 "Childhood Infections Research Program" (ChIRP). The goal of the program is to train postdoctoral scientists in areas of microbial pathogenesis and infectious diseases of children. The application proposes an innovative program that allows joint training of clinical ID fellows and postdoctoral scientists, resulting in investigators who are able to perform high impact research and train the next generation of scientists.