Conducting Research in Pediatric Hematology/Oncology

描述（由申请人提供）：分子生物学与人类基因组测序、日益复杂的生物信息学技术的发展、实验室发现向靶向抗肿瘤治疗的转化以及多模态治疗的进展一起出现了爆炸式发展。为了加速这一进展，必须在国家癌症研究所（NCI）概述的关键领域（癌症生物学，癌症预防和控制，癌症诊断，预后和治疗）开展科学严谨，高度综合的多学科培训计划。这项培训补助金将推进个性化医疗的使命，使下一代学术儿科血液学家/肿瘤学家对疾病发病机制、治疗和结局的理解个性化。拟议的培训计划的目标是建立一个独特的跨学科计划，利用医学和范德比尔特-英格拉姆癌症中心的范德比尔特学校的优势，我们目前在儿科血液学/肿瘤学的奖学金。我们的目标是培养学员成为成功的独立资助的科学研究人员在基础，转化，临床人群为基础的癌症研究。所有符合条件的学员都将获得医学博士学位。学位以及完成儿科或综合医学/儿科住院医师培训。预计每年将有两名新学员参加培训计划，该计划包括三年的培训，其中第二年和第三年的资金将由T32赠款提供。现有的研究计划包括癌症流行病学，预防和控制，宿主-肿瘤相互作用，信号转导和细胞增殖，基因组维护，胃肠道，胸部和头颈部以及乳腺癌的研究。此外，学员有机会与儿科，内科，外科，生物化学，心理学，化学，物理学，病理学，放射肿瘤学，细胞和发育生物学，生理学，药理学，神经学和免疫学部门的科学家合作。有两个明确的培训途径，这些研究机会属于：1）基础和转化研究，2）临床和基于人口的研究。基础和转化研究科学途径将侧重于三个主要的主题领域：基因组科学，化学生物学和蛋白质组学以及动物模型转化医学，并将为学员提供密集的指导研究经验，重点是实验室发现和实验室发现的翻译有针对性的抗肿瘤疗法。临床和基于人口的科学途径旨在为学员提供密集的指导研究经验，重点关注整个控制过程中的癌症，包括预防，诊断和治疗，支持性护理，生存和姑息治疗。每个途径都有一个压倒一切的重点，通过教学和指导研究提供深入的研究培训经验的计划目标。 公共卫生相关性：诊断、治疗和支持性护理的进步使大多数癌症和血液病儿童的预后得到显著改善。为了继续加快这一进展，必须有科学严谨、高度综合、多学科的培训方案，重点是癌症生物学、预防和控制、诊断、预后、治疗、生存和姑息治疗。拟议的儿科血液学/肿瘤学培训计划的目标是建立这样一个培训计划，利用范德比尔特医学院和范德比尔特-英格拉姆癌症中心的机构优势，学员将成为成功的独立资助的基础，转化，临床或基于人群的癌症研究的科学研究者。

DESCRIPTION (provided by applicant): There has been an explosion in molecular biology together with the sequencing of the human genome, development of increasingly complex bioinformatics techniques, translation of laboratory discoveries to targeting anti-neoplastic therapies and advances in multi-modality therapies. To accelerate such progress, it is essential to have scientifically rigorous, highly integrated, multidisciplinary training programs in the key areas outlined by the National Cancer Institute (NCI): cancer biology, cancer prevention and control, cancer diagnosis, prognosis and treatment. This training grant will advance the mission of personalized medicine to individualize understanding of disease pathogenesis, treatment and outcomes for the next generation of academic pediatric hematologists/oncologists. The goal of the proposed training program is to establish a unique interdisciplinary program that leverages the strengths of the Vanderbilt School of Medicine and the Vanderbilt-Ingram Cancer Center and our current fellowship in Pediatric Hematology/Oncology. Our objective is to prepare trainees to become successful independently-funded scientific investigators in basic, translational, clinical population-based cancer research. All eligible trainees will have already obtained an M.D. degree as well as completed residency training in pediatrics or combined medicine/pediatrics. It is anticipated that two new trainees per year will participate in the training program, which consists of three years of training, of which funding for Years 2 and 3 will be supported from funds from this T32 grant. The available programs of research include research in Cancer Epidemiology, Prevention and Control, Host-Tumor Interactions, Signal Transduction and Cell Proliferation, Genome Maintenance, Gastrointestinal, Thoracic and Head & Neck and Breast Cancer. In addition, trainees have the opportunity to work with scientists in the Departments of Pediatrics, Medicine, Surgery, Biochemistry, Psychology, Chemistry, Physics, Pathology, Radiation Oncology, Cell and Developmental Biology, Physiology, Pharmacology, Neurology, and Immunology. There are two defined training pathways under which these research opportunities fall: 1) Basic and Translational Research and, 2) Clinical and Population Based Research. The Basic and Translational Research Science Pathway will focus on three main thematic areas: genomic sciences, chemical biology and proteomics and translational medicine with animal models and will provide the trainee with an intensive mentored research experience that focuses on discovery in the laboratory and the translation of laboratory discoveries to targeted anti-neoplastic therapies. The Clinical and Population-Based Science Pathway is designed to provide the trainee with an intensive mentored research experience that focuses on cancer throughout the control continuum, including prevention, diagnosis and treatment, supportive care, survivorship and palliative care. Each of the pathways has programmatic goals with an over-riding emphasis to provide a deep research training experience through both didactic teaching and mentored research. PUBLIC HEALTH RELEVANCE: Advances in diagnosis, treatment and supportive care have led to significant improvement in outcome for the majority of children with cancer and blood disorders. To continue to accelerate such progress, it is essential to have scientifically rigorous, highly integrated, multi-disciplinary training programs focused on cancer biology, prevention and control, diagnosis, prognosis, treatment, survivorship and palliative care. The goal of the proposed pediatric hematology/oncology training program is to establish such a training program that leverages the institutional strengths of the Vanderbilt School of Medicine and the Vanderbilt-Ingram Cancer Center, where trainees will become successful independently-funded scientific investigators in basic, translational, clinical or population-based cancer research.