Conducting Research in Pediatric Hematology/Oncology

进行儿科血液学/肿瘤学研究

• 批准号: 8547785
• 负责人: Debra L. Friedman
• 金额: $ 13.79万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8547785
• 关键词: Pediatric Hematology/Oncology; Research

DESCRIPTION (provided by applicant): There has been an explosion in molecular biology together with the sequencing of the human genome, development of increasingly complex bioinformatics techniques, translation of laboratory discoveries to targeting anti-neoplastic therapies and advances in multi-modality therapies. To accelerate such progress, it is essential to have scientifically rigorous, highly integrated, multidisciplinary training programs in the key areas outlined by the National Cancer Institute (NCI): cancer biology, cancer prevention and control, cancer diagnosis, prognosis and treatment. This training grant will advance the mission of personalized medicine to individualize understanding of disease pathogenesis, treatment and outcomes for the next generation of academic pediatric hematologists/oncologists. The goal of the proposed training program is to establish a unique interdisciplinary program that leverages the strengths of the Vanderbilt School of Medicine and the Vanderbilt-Ingram Cancer Center and our current fellowship in Pediatric Hematology/Oncology. Our objective is to prepare trainees to become successful independently-funded scientific investigators in basic, translational, clinical population-based cancer research. All eligible trainees will have already obtained an M.D. degree as well as completed residency training in pediatrics or combined medicine/pediatrics. It is anticipated that two new trainees per year will participate in the training program, which consists of three years of training, of which funding for Years 2 and 3 will be supported from funds from this T32 grant. The available programs of research include research in Cancer Epidemiology, Prevention and Control, Host-Tumor Interactions, Signal Transduction and Cell Proliferation, Genome Maintenance, Gastrointestinal, Thoracic and Head & Neck and Breast Cancer. In addition, trainees have the opportunity to work with scientists in the Departments of Pediatrics, Medicine, Surgery, Biochemistry, Psychology, Chemistry, Physics, Pathology, Radiation Oncology, Cell and Developmental Biology, Physiology, Pharmacology, Neurology, and Immunology. There are two defined training pathways under which these research opportunities fall: 1) Basic and Translational Research and, 2) Clinical and Population Based Research. The Basic and Translational Research Science Pathway will focus on three main thematic areas: genomic sciences, chemical biology and proteomics and translational medicine with animal models and will provide the trainee with an intensive mentored research experience that focuses on discovery in the laboratory and the translation of laboratory discoveries to targeted anti-neoplastic therapies. The Clinical and Population-Based Science Pathway is designed to provide the trainee with an intensive mentored research experience that focuses on cancer throughout the control continuum, including prevention, diagnosis and treatment, supportive care, survivorship and palliative care. Each of the pathways has programmatic goals with an over-riding emphasis to provide a deep research training experience through both didactic teaching and mentored research.

描述（由申请人提供）：分子生物学爆炸以及人类基因组的测序，越来越复杂的生物信息学技术的发展，实验室发现的转化为靶向抗神经肿瘤疗法以及多模式疗法的进步。为了加快这种进步，必须在国家癌症研究所（NCI）概述的关键领域进行科学严格，高度综合的多学科培训计划：癌症生物学，预防癌症预防和控制，癌症诊断，预后和治疗。这项培训补助金将推进个性化医学的使命，以个性化对疾病发病机理，治疗和下一代学术儿科血液学家/肿瘤学家的结局的理解。拟议的培训计划的目的是建立一个独特的跨学科计划，该计划利用范德比尔特医学院和范德比尔特 - 伊吉拉姆癌症中心的优势以及我们目前在儿科血液学/肿瘤学领域的研究金。我们的目标是使学员在基础，基于临床人群的基础癌症研究中成为成功的独立科学研究者。所有合格的学员都将获得医学博士学位，并完成了儿科或联合医学/儿科的居住培训。预计，每年有两名新学员将参加培训计划，该计划包括三年的培训，其中2年和3年的资金将得到这笔T32赠款的资金。可用的研究计划包括癌症流行病学，预防和控制，宿主肿瘤相互作用，信号转导和细胞增殖，基因组维持，胃肠道，胸腔和头颈和乳腺癌。此外，学员有机会与儿科，医学，手术，生物化学，心理学，化学，物理学，病理学，辐射肿瘤学，细胞和发育生物学，生理学，药理学，神经病学和免疫学的科学家合作。这些研究机会有两个定义的培训途径：1）基础和转化研究以及2）基于临床和人群的研究。基本和转化研究科学途径将重点关注三个主要主题领域：基因组科学，化学生物学和蛋白质组学和动物模型的转化医学，并将为受训者提供密集的指导研究经验，重点是实验室中的发现以及实验室发现对靶向抗神经肿瘤疗法的翻译。基于临床和人群的科学途径旨在为学员提供密集的指导研究经验，该研究经验集中在整个控制连续性中，包括预防，诊断和治疗，支持性护理，生存和姑息治疗。每种途径都具有程序化目标，并具有过高的重点，可以通过教学教学和指导研究提供深入的研究培训经验。