Incorporation of a Hypertension Working Group into the Jackson Heart Study

将高血压工作组纳入杰克逊心脏研究

• 批准号: 8862527
• 负责人: Paul Muntner
• 金额: $ 47.54万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8862527
• 关键词: Address; Adherence; Advisory Committees; African; African American; Age-Years; Alabama; Ambulatory Blood Pressure Monitoring; Ancillary Study; Antihypertensive Agents; Applications Grants; Area; Atherosclerosis; Awareness; Behavioral; Biological Markers; Biometry; Blood; Blood Pressure; Cardiology; Cardiovascular Diseases; Cardiovascular system; Childhood; Clinical; Collaborations; Communities; Complex; Coronary heart disease; Data; Development; Diagnosis; Disease Outcome; Drug Formulations; Elements; End stage renal failure; Enrollment; Epidemiologic Studies; Epidemiology; Faculty; Funding; Future; Grant; Guidelines; Health; Healthcare; Heart Diseases; Heart failure; High Prevalence; Hour; Hypertension; Incidence; Individual; International; Investigation; Jackson Heart Study; Kidney; Kidney Diseases; Kidney Failure; Lead; Leadership; Manuscripts; Measurement; Measures; Mental Depression; Mentors; Mentorship; Minority; Monitor; Neighborhoods; New York; Outcome; Paper; Participant; Pattern; Persons; Pharmaceutical Preparations; Phenotype; Population; Prevention program; Principal Investigator; Process; Productivity; Protocols documentation; Psychosocial Factor; Public Health; Publishing; Race; Recording of previous events; Reporting; Research; Research Personnel; Resistant Hypertension; Risk Factors; Sampling; Solid; Specimen; Staging; Stress; Stroke; Universities; Urine; Visit; Writing; abstracting; base; blood pressure reduction; blood pressure regulation; cardiovascular disorder risk; cohesion; cohort; design; evidence base; experience; health belief; health disparity; hypertension control; hypertension treatment; improved; interest; lifetime risk; masked hypertension; medication compliance; meetings; minority health; multidisciplinary; novel; novel strategies; population based; preference; psychosocial; symposium; treatment program; working group

DESCRIPTION (provided by applicant): Beginning in childhood, African Americans have higher blood pressure (BP) levels than whites. In a recent analysis by our group, African Americans without hypertension at 45 years of age had > 90% lifetime risk for developing incident hypertension. Further, African Americans treated with antihypertensive medications are less likely to achieve guideline recommended BP levels when compared to whites on antihypertensive medications. The health care implications associated with hypertension in African Americans are profound; hypertension is a strong risk factor for stroke, heart failure, and end-stage renal disease (ESRD), conditions that occur more frequently among African Americans than whites. In this application, we propose to incorporate a Hypertension Working Group into the Jackson Heart Study (JHS-HWG). Four thematic areas of investigation are proposed: 1. Risk factors for incident hypertension; 2. BP phenotypes using 24 hour ambulatory BP monitoring (ABPM); 3. Uncontrolled treated hypertension including treatment resistant hypertension; and 4. Medication adherence. As the dysregulations underlying hypertension and BP control in African American are complex and likely multi-dimensional, we propose a multi- disciplinary team of investigators with complementary expertise in hypertension, health disparities, psychosocial health, epidemiology, biostatistics, and clinical cardiology. The JHS is an ideal population-based study to further our understanding of BP issues in African Americans. JHS enrolled 5,301 African Americans in 2000-2004 and data were collected on medication use and adherence, sub-clinical atherosclerosis measures, psychosocial variables, and blood and urine biomarkers during three study visits at 4 year intervals. Participants are being actively followed for the occurrence of clinical outcomes (e.g., coronary heart disease, hospitalized heart failure, and stroke). Additionally, ABPM was conducted at baseline in a sub-sample of 1,076 JHS participants, making this one of the largest population-based studies with ABPM in the US. ABPM can be used to estimate BP variability and diurnal BP, and diagnose white coat and masked hypertension, emerging cardiovascular disease risk factors that are understudied in African Americans. Another primary objective of the JHS - HWG will be to provide mentorship to early stage investigators (ESIs), with a special emphasis on under-represented researchers. This will include having ESIs lead JHS writing groups and JHS ancillary grant applications, to aid in their transition towards independence. The ESIs included in this application were chosen for their research potential, interest in minority health and the thematic areas in the application The principal investigators, who have an excellent track record of mentorship, will also be supported by an Advisory Committee and expert panel of Senior Faculty Mentors, who all have a strong history of mentorship as well as research productivity in minority health and hypertension-related areas. Finally, we plan to submit ancillary studies to JHS that make the JHS-HWG self-sustaining beyond the funding period.

描述（由申请人提供）：从童年开始，非洲裔美国人的血压（BP）水平高于白人。在我们小组最近的一项分析中，45岁时没有高血压的非裔美国人一生中发生高血压的风险为90%。此外，与服用降压药物的白人相比，接受降压药物治疗的非裔美国人达到指南推荐血压水平的可能性更小。与非裔美国人高血压相关的卫生保健影响是深远的；高血压是中风、心力衰竭和高血压的重要危险因素