UAB Institutional Career Development Program in HIV-Related Heart, Lung, Blood and Research

UAB 艾滋病毒相关心脏、肺、血液和研究机构职业发展计划

• 批准号: 10216327
• 负责人: Paul Muntner
• 金额: $ 40.38万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10216327
• 关键词: Acquired Immunodeficiency Syndrome; Adult; African American; Alabama; Area; Blood; Cardiovascular Diseases; Centers for Disease Control and Prevention (U.S.); Clinic; Cohort Studies; Collaborations; Disease; Educational workshop; Ethnic group; Fostering; Foundations; Funding; Geographic Locations; Goals; Grant; HIV; Heart; Heart Diseases; Hematological Disease; Hypertension; Incidence; Individual; Lead; Life Expectancy; Lipids; Lung; Lung diseases; Mentored Clinical Scientist Development Program; Mentors; Mentorship; NCI Scholars Program; National Heart, Lung, and Blood Institute; Patients; Prevalence; Principal Investigator; Program Development; Race; Records; Research; Research Methodology; Research Personnel; Research Project Grants; Research Training; Rotation; SECTM1 gene; Science; Site; Sleep; Sleep Disorders; Southeastern United States; Training; Training Programs; Universities; antiretroviral therapy; career development; design; didactic education; experience; high risk; method development; online course; programs; recruit; skill acquisition; training opportunity

The Centers for Disease Control (CDC) has estimated there were more than 1.1 million people in the US living with HIV in 2014. Effective antiretroviral therapy (ART) has increased the life expectancy of HIV+ individuals and the number of US adults living with HIV is projected to increase by almost 40% over the next decade. This has created a new challenge for people living with HIV in the US. People living with HIV have a high risk for heart, lung, blood and sleep related diseases (NHLBI-targeted diseases). Furthermore, the prevalence and incidence of both HIV and NHLBI-targeted diseases are higher among African Americans compared with other race/ethnic groups and in the South compared with other regions of the US. Despite the recognized importance of NHLBI-targeted diseases in people with HIV, few researchers have been trained in this area. The University of Alabama at Birmingham (UAB) is exceptionally well-suited to lead an institutional K12 Career Development Program in HIV-related heart, lung, blood and sleep research. The burden of HIV and NHLBI- targeted diseases is higher in the Southeast US compared with other geographic regions. The overall objective of this K12 grant is to develop and sustain a training program for scholars to gain interdisciplinary, intensive mentored research training and career development to become research leaders in the field of HIV- related heart, lung, blood and sleep disease. To accomplish this goal, we have designed a career development program that is interdisciplinary, involves didactic and experiential training opportunities, and contains intensive mentorship. The key activities we propose include to (1) develop and deliver an intensive, didactic curriculum with research rotations for additional skill development, (2) identify and recruit five scholars for training to conduct heart, lung, blood and sleep-related research in the context of HIV, (3) provide career development support through individual and team mentoring, (4) foster interdisciplinary team-science, and (5) provide tailored research projects for scholars to lead. The UAB program will collaborate with the other K12 awardees from this NHLBI program to maximize opportunities and experiences received by scholars through coordinating activities, including online courses. We will build this program on a strong foundation at UAB including (1) the Center for AIDS Research (CFAR), (2) a clinic site for major HIV studies (e.g., WIHS and REPRIEVE), (3) ongoing NHLBI-funded cohort studies (e.g., CARDIA), (4) a large pool of established senior mentors, (5) established research methods and career development workshops, (5) long-standing T32 and K12 training programs and (6) a CTSA. Also, the co-Principal Investigators for this grant have complimentary experience leading cardiovascular disease (Dr. Muntner) and HIV (Dr. Overton) research, strong track-records mentoring scholars towards independence, and an established research collaboration involving lipids and hypertension among patients with HIV. By completion of the K12 program, scholars be prepared to assemble, launch and lead interdisciplinary teams conducting HIV-related heart, lung, blood and sleep research.

疾病控制中心（CDC）估计，美国有超过110万人生活在 2014年感染艾滋病毒。有效的抗逆转录病毒疗法（ART）延长了HIV阳性个体的预期寿命 预计在未来十年，美国成年艾滋病毒携带者的数量将增加近40%。这 这给美国的艾滋病病毒感染者带来了新的挑战。艾滋病毒感染者有很高的风险 心脏、肺、血液和睡眠相关疾病（NHLBI靶向疾病）。此外，患病率和 非裔美国人的艾滋病毒和NHLBI目标疾病的发病率高于其他人， 种族/民族群体和南方与美国其他地区相比。尽管公认的 尽管NHLBI在艾滋病毒感染者中针对疾病的重要性，但很少有研究人员接受过这方面的培训。 亚拉巴马大学伯明翰分校（UAB）非常适合领导机构K12职业生涯 艾滋病相关心脏、肺、血液和睡眠研究发展计划。艾滋病毒和NHLBI的负担- 与其他地理区域相比，美国东南部的目标疾病更高。整体 这个K12赠款的目标是开发和维持一个培训计划，为学者获得跨学科， 强化指导研究培训和职业发展，成为艾滋病毒领域的研究领导者， 与心脏、肺、血液和睡眠有关的疾病。为了实现这一目标，我们设计了一个职业生涯 发展计划是跨学科的，涉及教学和经验的培训机会， 包含密集的指导。我们建议的主要活动包括（1）开发和提供一个密集的， 教学课程与研究轮换额外的技能发展，（2）确定和招聘五名学者 培训进行心脏，肺，血液和睡眠相关的研究，在艾滋病毒的背景下，（3）提供职业生涯 通过个人和团队指导提供发展支持，（4）培养跨学科团队科学，以及（5） 为学者提供量身定制的研究项目。UAB计划将与其他K12合作 获奖者从这个NHLBI计划，以最大限度地提高机会和经验的学者收到，通过 协调各项活动，包括在线课程。我们将在UAB的坚实基础上建立这个项目 包括（1）艾滋病研究中心（CFAR），（2）用于主要HIV研究的诊所站点（例如，WIHS和 REPRIEVE），（3）正在进行的NHLBI资助的队列研究（例如，（4）一个大型的高级人才库， 导师，（5）既定的研究方法和职业发展讲习班，（5）长期的T32和 K12培训计划和（6）CTSA。此外，该补助金的共同主要研究者 领导心血管疾病（Muntner博士）和HIV（Overton博士）研究的经验，强大的跟踪记录 指导学者走向独立，并建立了涉及脂质和 艾滋病病毒感染者的高血压。在K12项目完成后，学者们准备集合， 发起和领导跨学科小组，开展与艾滋病毒有关的心脏、肺、血液和睡眠研究。