UAB Cardiovascular Disease Predoctoral Training Program in Biostatistics and Epidemiology

大数据的可用性越来越高，这改变了我们提高对 心血管疾病(CVD)的病理生理学、患者水平的识别与公共卫生 预防心脑血管疾病发生的方法和护理质量方面的心血管疾病患者及其危险因素。 拟议的国家心肺和血液研究所T32心血管疾病培训补助金的目标是 让生物统计学和流行病学专业的学生在这两个学科都有扎实的基础，并赋予他们能力 他们将负责设计、实施和分析正在收集的 21世纪。位于美国东南部，心脏病死亡率最高的地区， 阿拉巴马大学伯明翰分校(UAB)一直处于心血管疾病生物统计学和流行病学的前沿 研究了超过25年。生物统计学和流行病学系是国际公认的 领导随机试验协调中心，作为协调中心和现场站点 流行病学研究，对健康保险索赔和电子病历数据进行分析，以及 开发统计遗传学/基因组学的新方法。对于此T32计划，我们正在申请资金用于 5年内共有12名博士前实习生，其中1年级每年新增2名实习生 通过4年级和5年级每年的3和3名新学员。参加T32计划的学员将获得 对心血管疾病的病理生理学和流行病学有扎实的基础，具备设计和实施观察法的技能 研究、培训心血管疾病研究的严密性和重复性，熟悉真实世界的数据 收集和分析，有进行大数据分析的经验，包括组学数据、拨款申请 UAB和更大的心血管疾病研究人员科学界内的经验和网络机会。 博士前实习生将完成为他们的生物统计学博士项目提供附加值的活动 和流行病学，包括教学交叉培训课程、赠款撰写课程和研讨会、研究 沉浸在大数据、专业发展研讨会、CVD研讨会和一份期刊这三个领域 俱乐部。我们为这笔T32赠款设计了三个工作坊，包括一个为期8周的暑期培训计划 CVD，一个高性能计算新兵训练营和一个关于团队科学和交流的研讨会。这个 培训计划的顶峰经验是一个有指导的研究项目，导致同行审查 手稿。该项目将由生物统计学全职教授赫曼特·蒂瓦里博士和保罗·蒙特纳博士领导 和流行病学，分别有很强的指导记录和项目开发经验。我们 已收到来自以下部门的14名初级导师和11名中学导师的承诺 生物统计学和流行病学。来自UAB各地的另外21名教职员工承诺为 作为内容导师。拟议的博士前T32培训计划将培养一批生物统计学家干部 流行病学家准备领导心血管疾病研究，解决NHLBI的优先事项。

The increasing availability of “big data” has transformed the training required to advance our understanding of the pathophysiology of cardiovascular disease (CVD), the identification of patient-level and public health approaches to prevent its occurrence and aspects of quality of care for patients with CVD and its risk factors. The goal of the proposed pre-doctoral National Heart, Lung, and Blood Institute T32 CVD training grant is to engage and empower biostatistics and epidemiology students with a strong foundation in both disciplines so they will be positioned to lead the design, conduct and analysis of the big data that are being collected in the 21st century. Located in the Southeastern US, an area with the highest heart disease death rates, the University of Alabama at Birmingham (UAB) has been at the forefront of CVD biostatistics and epidemiology research for over 25 years. The Departments of Biostatistics and Epidemiology are internationally recognized for leading randomized trial coordinating centers, serving as the coordinating center and field sites for epidemiology studies, conducting analyses of health insurance claims and electronic medical record data, and developing new methods for statistical genetics/genomics. For this T32 program, we are requesting funding for a total of 12 pre-doctoral trainees over the course of 5 years including 2 new trainees in each of years 1 through 3 and 3 new trainees in each of years 4 and 5. Trainees enrolled in the T32 program will receive a strong foundation in the pathophysiology and epidemiology of CVD, skills to design and conduct observational research, training on rigor and reproducibility in CVD research, familiarity with how real-world data are collected and analyzed, experience conducting big data analytics including omics data, grant writing experience, and networking opportunities within UAB and the larger scientific community of CVD researchers. Pre-doctoral trainees will complete activities that provide added value to their doctoral programs in biostatistics and epidemiology including didactic cross-training courses, a grant writing class and workshop, research immersions in three areas of big data, professional development workshops, and CVD seminars and a journal club. We have designed three workshops for this T32 grant including an 8-week summer training program on CVD, a high performance computing boot camp and a workshop on team science and communication. The training program’s capstone experience is a mentored research project resulting in a peer-reviewed manuscript. The program will be led by Drs. Hemant Tiwari and Paul Muntner, full professors in Biostatistics and Epidemiology, respectively, with strong mentoring records and program development experience. We have received the commitment from 14 primary mentors and 11 secondary mentors from the Departments of Biostatistics and Epidemiology. An additional 21 faculty members from across UAB have committed to serve as content mentors. The proposed pre-doctoral T32 Training Program will produce a cadre of biostatisticians and epidemiologists prepared to lead CVD research studies that address the priorities of NHLBI.