Breast Cancer Research (Project-005)

乳腺癌研究（项目-005）

• 批准号: 8928337
• 负责人: TIMOTHY J EBERLEIN
• 金额: $ 8.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-02 至 2020-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8928337
• 关键词: Achievement; Area; Basic Science; Benign; Biological Assay; Biological Markers; Body Weight decreased; Breast; Breast Cancer Treatment; Breast Cancer survivor; Cancer Biology; Cancer Center Support Grant; Cancer Research Project; Case Study; Cells; Childhood; Clinical; Clinical Oncology; Clinical Research; Clinical Sciences; Clinical Treatment; Clinical Trials; Collaborations; DNA Vaccines; Descriptor; Development; Diagnosis; Diet; Disease; Drug-sensitive; Etiology; Funding; Future; Genome; Genomic approach; Genomics; Genotype; Goals; Growth; Height; Human Subject Research; Image; Intervention; Invasive Lesion; Journal of the National Cancer Institute; Journals; Lesion; Life Style; Malignant Neoplasms; Malignant neoplasm of prostate; Nature; Neoplasm Metastasis; Pathology; Patients; Peer Review; Population Sciences; Predisposition; Premalignant; Prevention program; Prevention strategy; Proteomics; Publications; Reporting; Research; Risk; Role; Schools; Signal Transduction Pathway; Somatic Mutation; Staging; Therapeutic; Translational Research; Treatment Protocols; Universities; Vaccines; Validation; Washington; Woman; Xenograft procedure; abstracting; base; cancer genomics; cancer risk; clinical investigation; clinically relevant; cohort; design; immunogenic; improved; malignant breast neoplasm; member; novel strategies; novel therapeutic intervention; pre-clinical; programs; prospective; risk variant; tumor microenvironment; working group

THIS COMPONENT IS ENTITLED BREAST CANCER RESEARCH PROGRAM ABSTRACT The long-term goals of the Breast Cancer Research Program (BCRP) are to elucidate the basic mechanisms that regulate breast cancer pathology and to use this information to develop strategies for prevention, diagnosis and treatment of all stages and subtypes of breast cancer. Working groups in clinical, basic and population sciences have been established to identify and develop novel strategies for implementation in the diagnosis and treatment of breast cancer. These three groups work in collaboration guided by the hypothesis that advances in basic and population science can be leveraged to have a unique clinical impact in successfully treating breast cancer. These translational efforts are categorized in three specific aims: Aim 1. To expand clinical treatment of breast cancer using research-based paradigms. Aim 2. To utilize institutional expertise in basic sciences to identify new translational targets and treatment regimens and help advance these clinically. Aim 3. To reduce risk and ethnic disparities in breast cancer through targeted prevention and genomic strategies. There are 23 CCSG members from 8 departments and 3 schools. Currently BCRP funding exceeds $13.5 million including $4.7 million in NCI funding and $6 million in other peer-reviewed funding. BCRP publications from 2009-2014 include 365 total publications, with 39% inter-programmatic publications and 14% intra- programmatic publications that included contributions to Nature, Cell Reports, Journal of Clinical Investigation, Journal of Clinical Oncology and Journal of the National Cancer Institute. In the summary of the broad ranging achievements and future objectives of the program, program descriptors are organized into three main areas of research: clinical and translational research, basic research and population science.

本部分题为乳腺癌研究摘要 乳腺癌研究计划（BCRP）的长期目标是阐明基本的 调节乳腺癌病理学的机制，并利用这些信息制定策略， 预防、诊断和治疗所有阶段和亚型的乳腺癌。临床工作组， 建立了基础科学和人口科学，以确定和发展新的战略， 在乳腺癌的诊断和治疗中的应用。这三个小组协同工作 在基础科学和人口科学的进步可以被杠杆化的假设的指导下， 成功治疗乳腺癌的临床影响。这些翻译工作分为三种 具体目标： 目标1.使用基于研究的范例扩大乳腺癌的临床治疗。 目标2.利用机构在基础科学方面的专业知识，确定新的转化靶点和治疗方法 方案，并帮助推进这些临床。 目标3。通过有针对性的预防和基因组治疗减少乳腺癌的风险和种族差异 战略布局 有23名CCSG成员来自8个部门和3所学校。目前BCRP的资金超过13.5美元 其中包括470万美元的NCI资金和600万美元的其他同行评审资金。BCRP出版物 2009-2014年的出版物总数为365种，其中39%为计划间出版物，14%为计划内出版物。 程序性出版物，包括对Nature，Cell Reports，Journal of Clinical Investigation， 临床肿瘤学杂志和国家癌症研究所杂志。在广泛的总结 的成就和未来的目标，计划描述被组织成三个主要领域， 研究：临床和转化研究、基础研究和人口科学。