Mechanisms Underlying the Vascular Pathology of Alzheimer's Disease
Mechanisms Underlying the Vascular Pathology of Alzheimer's Disease
批准号:
7907843
负责人:
Gregory A. Elder
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-10-01 至 2013-03-31
关键词:
AccountingAddressAffectAge of OnsetAgingAlzheimer&aposs DiseaseAmyloid beta-Protein PrecursorBasal laminaBasement membraneBlood VesselsBrainBrain regionCD29 AntigenCell LineCerebral Amyloid AngiopathyCerebral hemisphere hemorrhageClinicalDementiaDiseaseDown SyndromeEmbryoEndothelial CellsEventExhibitsExtracellular MatrixFibronectin ReceptorsFibronectinsFunctional disorderGenesGenetic Predisposition to DiseaseGrowth FactorHumanHuman PathologyImpaired cognitionIn VitroInheritedIntegrin alpha5beta1IntegrinsLeadMissionModelingMolecularMusMutant Strains MiceMutationNeurofibrillary TanglesNeuronsPathologyPathway interactionsPatientsPopulationPresenile Alzheimer DementiaProcessProductionProteinsRecurrenceRegulationRelative (related person)RoleSenile PlaquesSignal TransductionSyndromeTestingTransgenic AnimalsTransgenic MiceTransgenic ModelTransgenic OrganismsVascular remodelingVeteransage relatedbasebrain tissuecerebral atrophydensityearly onseteffective therapyfamilial Alzheimer diseasein vivomutantnew therapeutic targetoverexpressionpresenilin-1presenilin-2programspublic health relevanceresponse
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