ADVANCED IMAGING

高级成像设施核心（AIFC）是综合设施核心计划的一部分，该计划包括 集成发现管道中的假设生成、测试和转换资源，旨在 加速和推进创新理念从假设到实践。AIFC的主要目标是 为CTEHR研究人员提供最先进的成像技术，可用于可视化和 量化活的和固定的细胞和组织中外源性物质的影响。通过结合最先进的技术 通过一个用于数据挖掘和共享的复杂信息学程序，该核心还将使研究人员能够 解决EHS研究中一些最具挑战性的问题。AIFC将发挥不可或缺的作用， 通过实现以下目标，支持中心的人权使命： 目标1：保持广泛的最先进的显微镜技术和专业知识，以解决 CTEHR研究的多样化成像需求; 目标2：为CTEHR研究人员提供具有成本效益的，优先获得分析显微镜工具， 为实验设计提供高效的仪器培训和咨询服务， 应用程序开发和数据分析; 目标3：教育CTEHR成员了解现有和新兴显微技术的能力 和应用程序，并支持中心研究人员的职业发展和指导活动; 目标4：促进转化研究活动和下一代光学显微镜计划， 与其他CTEHR设施核心和生物医学光学研究人员的互动， 中心的技术主题重点领域。 AIFC通过提供先进的技术、专业的培训和技术支持， 在细胞毒性、遗传毒性、致突变性和内分泌干扰物分析方面具有广泛的专业知识， 各种环境化学品的活动。广泛的显微镜硬件/软件， 光学和电子显微镜和全自动高通量图像为基础的筛选设施将使它 中心研究人员可以以较低的成本获得昂贵的、快速发展的仪器和专业知识， 有效的时尚。使用强大的AIFC成像基础设施， 测试关于细胞与环境因素之间关键相互作用的新假设， 人类健康和疾病。

The Advanced Imaging Facility Core (AIFC) is part of an integrated Facility Core program consisting of hypothesis generating, testing, and translational resources within an Integrated Discovery Pipeline, designed to accelerate and advance innovative ideas from hypothesis to practice. The primary goal of the AIFC is to provide CTEHR investigators with state-of-the-art imaging technologies that can be used to visualize and quantify the effects of xenobiotics in live and fixed cells and tissues. By combining state-of-the-art technologies with a sophisticated program of informatics for data mining and sharing, this Core will also allow researchers to tackle some of the most challenging questions in EHS research. The AIFC will play an integral role in supporting the CTEHR mission by carrying out the following aims: Aim 1: Maintain a wide range of state-of-the-art microscopy technologies and expertise to address the diverse imaging needs of CTEHR research; Aim 2: Provide CTEHR investigators with cost effective, prioritized access to analytical microscopy tools, efficient and effective instrument training and consulting services for experimental design, applications development and data analysis; Aim 3: Educate CTEHR members about the capabilities of existing and emerging microscopy technologies and applications and support the career development and mentoring activities of Center investigators; Aim 4: Facilitate translational research activities and next generation optical microscopy initiatives through interactions with the other CTEHR Facility Cores and biomedical optics investigators in the Enabling Technologies Thematic Focus Area of the Center. The AIFC fills a critical need for CTEHR investigators by delivering advanced technologies, specialized training and extensive expertise in the analysis of the cytotoxic, genotoxic, mutagenic, and endocrine disrupting activities of a variety of environmental chemicals. A wide range of microscopy hardware/software for advanced light and electron microscopy and fully automated high throughput image-based screening facilities will make it possible for Center investigators to access expensive, rapidly evolving instrumentation and expertise in a cost effective fashion. Access to the powerful AIFC imaging infrastructure provides the opportunity to develop and test novel hypotheses about the critical interactions between cells and environmental factors that contribute to human health and disease.