Protect Patient Safety Through Herb-Drug-Disease Interaction Detection and Alert

项目摘要 补充和替代医学（CAM）的使用在患者中很普遍。虽然许多 CAM实践被认为是安全的（例如瑜伽），基于生物学的CAM可以与 处方药和影响患者的结果。我们将集中讨论一种生物学上的- 基于CAM，草药产品，在这项研究。尽管存在安全问题，但缺乏病人- 关于CAM的临床医生沟通使得难以评估和减轻草药的风险， 药物-疾病相互作用此外，许多供应商和消费者缺乏草药知识， 药我们提出了一个信息化的解决方案，以改善CAM通信， 医生和患者的潜在安全问题。随着时间的推移，改进后的文档可以 也为生物基CAM的有效性和安全性研究提供数据。在这 项目，我们将专注于心血管疾病患者。具体目标是：1. 开发一个计算机访问应用程序，直接从患者那里收集CAM数据; 2.发展 警报系统，用于检测草药-药物-疾病的相互作用，并向医生和患者发出警报; 3.评估CAM数据收集和警报系统是否可以帮助患者和医生识别 服用可能有害的产品，增加患者与医生关于CAM的沟通， 并触发防止草药-药物-疾病相互作用的行动。

Project Abstract Complementary and alternative medicine (CAM) usage is prevalent in patients. While many CAM practices are considered safe (e.g. yoga), biologically-based CAM could interact with prescription medications and impact patients' outcomes. We will focus on a type of biologically- based CAM, herbal products, in this study. Despite the safety concerns, the lack of patient- clinician communication regarding CAM makes it difficult to assess and mitigate the risk of herb- drug-disease interactions. In addition, many providers and consumers lack knowledge of herbal medicine. We propose an informatics solution to improve CAM communication, and alert physicians and patients of potential safety issues. Over time, the improved documentation could also provide data for research on the efficacy and safety of biologically-based CAM. In this project, we will focus on patients with cardiovascular diseases. The specific aims are: 1. Develop a computer interview application to collect CAM data directly from patients; 2. Develop an alert system to detect herb-drug-disease interactions and alert both physicians and patients; 3. Evaluate if the CAM data collection and alert system can help patients and physicians identify potentially harmful products being taken, increase patient-physician communication about CAM, and trigger actions to prevent herb-drug-disease interactions.