Protect Patient Safety Through Herb-Drug-Disease Interaction Detection and Alert

描述(由申请人提供)：补充和替代医学(CAM)的使用在患者中很普遍。虽然许多CAM实践被认为是安全的(例如瑜伽)，但基于生物的CAM可能会与处方药相互作用，并影响患者的结果。在这项研究中，我们将重点研究一种基于生物的CAM-草药产品。尽管存在安全问题，但缺乏关于CAM的患者-临床医生沟通，使得评估和减轻草药-药物-疾病相互作用的风险变得困难。此外，许多供应商和消费者缺乏草药知识。我们提出了一种信息学解决方案来改善CAM通信，并提醒医生和患者潜在的安全问题。随着时间的推移，改进的文件还可以为基于生物的CAM的有效性和安全性的研究提供数据。在这个项目中，我们将重点关注心血管疾病患者。具体目标是：1.开发计算机访谈应用程序，直接从患者那里收集CAM数据；2.开发警报系统，以检测草药-药物-疾病相互作用，并向医生和患者发出警报；3.评估CAM数据收集和警报系统是否可以帮助患者和医生识别正在服用的潜在有害产品，增加患者-医生关于CAM的沟通，并触发防止草药-药物-疾病相互作用的行动。

DESCRIPTION (provided by applicant): Complementary and alternative medicine (CAM) usage is prevalent in patients. While many CAM practices are considered safe (e.g. yoga), biologically-based CAM could interact with prescription medications and impact patients' outcomes. We will focus on a type of biologically-based CAM, herbal products, in this study. Despite the safety concerns, the lack of patient-clinician communication regarding CAM makes it difficult to assess and mitigate the risk of herb-drug-disease interactions. In addition, many providers and consumers lack knowledge of herbal medicine. We propose an informatics solution to improve CAM communication, and alert physicians and patients of potential safety issues. Over time, the improved documentation could also provide data for research on the efficacy and safety of biologically-based CAM. In this project, we will focus on patients with cardiovascular diseases. The specific aims are: 1. Develop a computer interview application to collect CAM data directly from patients; 2. Develop an alert system to detect herb-drug-disease interactions and alert both physicians and patients; 3. Evaluate if the CAM data collection and alert system can help patients and physicians identify potentially harmful products being taken, increase patient-physician communication about CAM, and trigger actions to prevent herb-drug-disease interactions.