P2X7 mediated phagocytosis of apoptotic cells: a common mechanism underlies neurological and eye disorders

P2X7 介导的凋亡细胞吞噬作用：神经和眼部疾病的常见机制

• 批准号: nhmrc : 1048082
• 负责人: Dr Ben Gu
• 金额: $ 35.14万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/p2x7-mediated-phagocytosis-eye-disorders/111996
• 关键词: P2X7; mediated; phagocytosis; apoptotic; cells

We have found a strong genetic linkage between a protein called P2X7 and a number of neurological disorders, in line with our recent discovery of a novel function of this protein in clearance of dying cells as removal of unhealthy neurons is essential to keep brain function promptly. Further study using genetic association, cell biology and animal models will lead to a conceptual advance on how neurological diseases are occurred and developed.

我们发现一种名为 P2X7 的蛋白质与许多神经系统疾病之间存在很强的遗传联系，这与我们最近发现的这种蛋白质清除垂死细胞的新功能一致，因为清除不健康的神经元对于及时保持大脑功能至关重要。使用遗传关联、细胞生物学和动物模型的进一步研究将导致神经系统疾病如何发生和发展的概念上的进步。