The role of reduced phagocytosis in the pathogenesis of Age-related Macular Degeneration

吞噬作用减少在年龄相关性黄斑变性发病机制中的作用

• 批准号: nhmrc : 1120095
• 负责人: Dr Ben Gu
• 金额: $ 53.68万
• 依托单位: Centre for Eye Research Australia Ltd
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-reduced-phagocytosis-macular-degeneration/946432
• 关键词: role; reduced; phagocytosis; pathogenesis; Age

Understanding the underlying mechanisms which lead to age-related macular degeneration (AMD) is critical if we are to ultimately develop novel treatments. We hypothesise that there is a defective ability to remove debris that accumulates in the retina as we age and this is a crucial step in the development of AMD. We will investigate this hypothesis in an AMD cohort and in a pre-clinical model where we will test the efficacy of an intervention that improves the ability to clear debris.

如果我们最终要开发新的治疗方法，了解导致年龄相关性黄斑变性（AMD）的潜在机制是至关重要的。我们假设，随着年龄的增长，清除积聚在视网膜上的碎片的能力存在缺陷，这是AMD发展的关键一步。我们将在AMD队列和临床前模型中研究这一假设，在临床前模型中，我们将测试提高清除碎片能力的干预措施的有效性。