Age, Gene/environment Susceptibility Study In Iceland - Ocular Component

冰岛的年龄、基因/环境易感性研究 - 眼部成分

• 批准号: 9175886
• 负责人: VILMUNDUR GUDNASON
• 金额: $ 50.86万
• 依托单位: ICELANDIC HEART ASSOCIATION
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9175886
• 关键词: Adult Children; Affect; Age; Age related macular degeneration; Aging; Ancillary Study; Atherosclerosis; Bibliography; Blood Vessels; Body Composition; Brain; Caliber; Candidate Disease Gene; Clinic; Clinic Visits; Clinical; Cohort Studies; Consult; Contracts; Cross-Sectional Studies; DNA; Data; Degenerative polyarthritis; Dementia; Deposition; Diabetes Mellitus; Diabetic Retinopathy; Disease; Elderly; Enrollment; Environment; Epidemiology; Event; Exhibits; Eye; Eye diseases; Functional disorder; Funding; Fundus; Genes; Genetic; Genomics; Genotype; Health; Heart; Hip region structure; Home environment; Hyperglycemia; Iceland; Individual; Institutes; International; Joints; Kidney; Lesion; Lipids; MEDLINE; Measures; Medical; Mental Depression; Meta-Analysis; Metabolic Diseases; Musculoskeletal Diseases; National Heart, Lung, and Blood Institute; National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; Neurocognitive; Obesity; Paper; Participant; Pathology; Pattern; Persons; Phenotype; Physical Function; Planet Mars; Predisposition; Prevalence; PubMed; Publishing; Pupil; Relative (related person); Research; Research Design; Retina; Retinal; Retinal Diseases; Risk; Risk Factors; Running; Schedule; Serum; Specimen; Subgroup; Survivors; Target Populations; Testing; United States National Institutes of Health; Ventricular; Vertebral column; Visit; aging gene; base; bead chip; body system; cardiovascular health; cognitive ability; cohort; digital imaging; exome; follow-up; genetic profiling; genetic variant; indexing; interest; lifestyle factors; macula; member; multidisciplinary; normal aging; phenomics; retina blood vessel structure; sarcopenia; web site

The Age Gene/Environment Susceptibility -Reykjavik Study (AGES) was conceived as a cross-sectional study to assess the relative contribution of candidate genes and interrelationships of diseases common in old age by reexamining the Icelandic Reykjavik Cohort established in 1967. This is a collaborative project between the Icelandic Heart Association (IHA) and the NIA (funded under a contract mechanism). Other NIH Institutes (NIDCD, NHLBI, NINDS, and NEI) have added components also. At the study outset, the target population was to be the roughly 9,500 surviving members of the Reykjavik Study Cohort (then ages 65-94) of whom up to 8,000 would undergo a complete clinic examination over three clinic visits and 1,500 of the very old or physically frail would undergo a modified examination in their home. Enrollment into the main study began in September 2002. Three separate visits were required to complete the extensive battery of study testing. The three study visits were run concurrently and each of the three visits was scheduled to occur within an approximately two month window. In December 2002, the NEI added an ocular component. Recruitment ended in 2006, earlier than planned, due to fiscal constraints. Enrolled are 5,764 elderly Icelanders. Detailed health and medical information from previous examinations of the cohort as well as stored serum and other biologic specimens are available. Phenotypes of interest for the study include: neurocognitive conditions (dementia, depression, neurosensory profile), cardiovascular health (atherosclerosis, arterial distensibility, ventricular and valvular disease), musculoskeletal conditions (spine and hip osteoprosis, joint osteoarthritis, strength and function), and body composition and metabolic disease (obesity, sarcopenia, hyperglycemia, diabetes). The eye component included an acuity assessment and capturing digital images of the fundus and macular regions of the retina as taken through dilated pupils in both eyes. An objective of this project is to estimate the prevalence of retinal phenotypes, particularly age-related macular degeneration and diabetic retinopathy, in this elderly cohort and determine whether specific genetic profiles increase risk of pathology. Of perhaps greater interest, is the rich opportunity to explore patterns among multiple phenotypes and multiple genotypes that influence overall health in the elder years. For example, do vascular phenomena observed in retina vessels correlate with vascular changes elsewhere in the body and are the same genes involved? Are circulating measures of lipid predictive of lipid deposits elsewhere in the body, including the retinal and brain, and are these patterns part of normal aging or indicative of disease? What is the neurosensory profile of people in this aging cohort, how does it affect physical or cognitive ability, and are there genetic or lifestyle factors which mitigate risk? The AGES cohort has been followed for clinical events and survival. A group of AGES survivors were re-examined in a longitudinal follow-up between 2008 and 2011. Adult Offspring of selected AGES participants are participating in an ancillary study in 2014-2015. DNA on a subgroup of the AGES participants was genotyped in 2009 using an Illumina 370CNV BeadChip array. Exome chip genotyping data became available in 2013. For addition information about the conceptual framework for AGES, consult Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics. Harris TB, Launer LJ, Eiriksdottir G, Kjartansson O, Jonsson PV, Sigurdsson G, Thorgeirsson G, Aspelund T, Garcia ME, Cotch MF, Hoffman HJ, Gudnason V.Am J Epidemiol. 2007 May 1;165(9):1076-87. Epub 2007 Mar 10. PMID: 17351290 PubMed - indexed for MEDLINE Free PMC Article.

年龄基因/环境易感性-雷克雅未克研究(AGES)被设想为一项横断面研究，通过重新审查1967年建立的冰岛雷克雅未克队列，评估候选基因的相对贡献和老年常见疾病的相互关系。这是冰岛心脏协会(IHA)和NIA(根据合同机制提供资金)之间的合作项目。其他NIH研究所(NIDCD、NHLBI、NINDS和NEI)也增加了组件。 在研究开始时，目标人群是雷克雅未克研究队列中大约9500名幸存成员(当时年龄在65岁至94岁之间)，其中多达8000人将在三次诊所就诊后接受全面临床检查，1500名高龄或身体虚弱的人将在家中接受改装检查。2002年9月开始注册参加主要研究。需要三次单独的访问才能完成广泛的研究测试。三次考察访问是同时进行的，每一次访问都计划在大约两个月的窗口内进行。2002年12月，NEI增加了一个眼部部件。由于财政限制，征聘工作于2006年结束，比原计划提前。登记的有5764名冰岛老年人。 从以前的队列检查以及储存的血清和其他生物标本中可以获得详细的健康和医学信息。这项研究感兴趣的表型包括：神经认知状况(痴呆症、抑郁症、神经感觉状况)、心血管健康状况(动脉粥样硬化、动脉扩张性、脑室和瓣膜疾病)、肌肉骨骼状况(脊柱和髋部骨质疏松症、关节骨关节炎、力量和功能)以及身体成分和代谢疾病(肥胖、骨质疏松症、高血糖、糖尿病)。眼睛部分包括视力评估和通过双眼扩大的瞳孔拍摄的视网膜眼底和黄斑区的数字图像。 该项目的一个目标是评估视网膜表型的患病率，特别是年龄相关性黄斑变性和糖尿病视网膜病变，并确定特定的基因特征是否会增加病理风险。也许更令人感兴趣的是探索影响老年人整体健康的多种表型和多种基因型之间的模式的丰富机会。例如，视网膜血管中观察到的血管现象是否与身体其他部位的血管变化相关，是否涉及相同的基因？循环中的脂类指标是否预示着体内其他部位的脂类沉积，包括视网膜和大脑，这些模式是正常衰老的一部分还是疾病的迹象？在这个老龄化队列中的人的神经感觉特征是什么，它如何影响身体或认知能力，是否有遗传或生活方式因素来降低风险？ 对于临床事件和存活率，已经跟踪了年龄队列。在2008至2011年间的纵向随访中，对一组年龄幸存者进行了重新检查。选定年龄的参与者的成年后代将参加2014-2015年的一项辅助研究。 2009年，使用Illumina 370CNV珠芯片阵列对AGEs参与者的一个亚组的DNA进行了基因分型。Exome芯片基因分型数据于2013年提供。 有关AGEs概念框架的更多信息，请咨询年龄、基因/环境易感性-雷克雅未克研究：多学科应用表型组学。首页--期刊主要分类--期刊细介绍--期刊题录与文摘--期刊详细文摘内容2007年5月1日；165(9)：1076-87。EPub 2007年3月10日 PMID：17351290 PubMed-索引为MEDLINE Free PMC文章。