Age, GenelEnvironment Susceptibility-Reykjavik Study Continuation

启动了年龄、基因/环境易感性(AGEs)-雷克雅未克研究，以检查潜在的遗传易感性和基因/环境相互作用，因为这些因素导致疾病、残疾和死亡风险。这项研究的前提是，许多老年疾病，如心血管疾病、骨质疏松症和阿尔茨海默病，可能具有共同的病理生理机制，如炎症和血糖失调，以及共同的遗传因素支撑这些机制。了解基因对老年慢性病的贡献可以创造新的干预措施来预防疾病和限制残疾。

The Age, Gene/Environment Susceptibility (AGES) -Reykjavik Study was initiated to examine potential genetic susceptibility and gene/environment interaction as these contribute to disease, disability, and risk of death. The study is based on the premise that many conditions in old age, such as cardiovascular disease, osteoporosis, and Alzheimer's disease, may share common pathophysiologic mechanisms such as inflammation and glucose dysregulation, and that common genetic factors underlie these mechanisms. Understanding the genetic contribution to chronic diseases of old age could create novel interventions to prevent disease and limit disability.