DCTD Animal Support

DCTD 动物支持

• 批准号: 8008864
• 负责人: LARRY ARTHUR
• 金额: $ 97.8万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2018-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8008864
• 关键词: Accreditation; Animal Experimentation; Animal Husbandry; Animal Model; Animals; Antibody Formation; Antineoplastic Agents; Area; Autoimmune Process; Autopsy; Bacterial Toxins; Biological; Biological Assay; Biological Testing; Caring; Charge; Chemistry; Clinical Trials; Communities; Consultations; Contracts; Development; Developmental Therapeutics Program; Diabetes Mellitus; Diagnostic; Diagnostic Services; Dichloroacetate; Disease; Disease Progression; Dose; Drug Kinetics; Early Diagnosis; Fluorescence; Funding; Gas Chromatography; Government Agencies; HIV; Health; Health Status; Helicobacter; High Pressure Liquid Chromatography; IACUC; Individual; Infection; Institution; International; Investigation; Knowledge; Laboratories; Laboratory Animal Medicine; Laboratory Animal Science; Laboratory Animals; Lead; Liquid substance; Malignant Neoplasms; Mass Spectrum Analysis; Metabolic; Metabolic Diseases; Methodology; Microbiology; Molecular; Monitor; Mus; Needs Assessment; Parasitology; Pharmaceutical Preparations; Pharmacology; Phase; Plasma; Play; Preclinical Testing; Production; Proteomics; Quarantine; Research; Resources; Rodent; Role; Route; Sampling; Schedule; Sentinel; Serologic tests; Services; Source; Spectrum Analysis; Support Groups; Testing; Time; United States; United States National Institutes of Health; Urine; Viral; Virus Diseases; Weight; animal care; animal efficacy; animal facility; base; biosecurity; drug candidate; human disease; in vivo; interest; pathogen; pre-clinical; preclinical study; prevent; programs; response; small molecule; square foot; ultraviolet

BTB Support - The Biological Testing Branch Support Group is responsible for providing information relating to the preclinical chemistry and pharmacology of new anticancer agents identified by the Developmental Therapeutics Program. The analysis of drug candidates in biological fluids involves creating, applying, and validating methodology for each drug candidate. This analytical methodology then permits investigation into possible inter-relationships between dose, bio-fluid (such as plasma or urine) concentration, and bio-effect. The results of such studies may lead to a better understanding of drug activity as well as suggest the best route and dose schedule for administration. Such efforts requires extensive knowledge of high performance liquid chromatography (HPLC), gas chromatography (GC), and molecular spectroscopy such as ultraviolet (UV), fluorescence, and all forms of mass spectrometry. Additionally, this group was charged with providing pharmacological support to the recently implemented NCI-sponsored Phase 0 clinical trials. In addition to the scientific studies supported by this effort, this group is also responsible for providing administrative support to the DCTD Animal Production Program. This program supplies rodents to the NCI, NIH, USAMRIID, FDA and other government agencies. In addition, surplus animals are provided to NIH grantees on an as-available basis. This effort supports many of the preclinical studies required to develop drugs to treat cancer, HIV and other viral diseases, bacterial and toxin-induced diseases, metabolic diseases including diabetes, immunologically induced conditions including autoimmune conditions, and other disease states supported by Federal research funds. DTP Animal QC - Animal models of human disease continue to play a pivotal role in our understanding of disease progression and treatment. As part of the support to the diverse array of animal model studies, DCTD has animal production contracts that provide rodents to the NCI, NIH, FDA, USAMRIID, other Federal agencies as well as NIH grantees on an as available basis. As part of this effort, DCTD routinely assesses the health status of the animals being distributed so as to assure the research community of the quality and biosecurity of the research animals they receive. To this end, the Laboratory Animal Sciences Program (LASP) provides diagnostic services for routine and special-need assessments of the health status of the animal production colonies. These assays include murine antibody production (MAP) tests which identify occult viral infections, PCR-based assays for Helicobacter and certain viral agents as well as bacteriological assessment of rodent and fomite-derived samples to assure the status of the production colonies. In addition, this laboratory monitors the health of all rodent colonies at NCI-Frederick which further protects the DCTD Animal Production Program by identifying and eliminating possible sources of infection within the Frederick campus. Animal Health Diagnostic Laboratory (AHDL) - The Animal Health Diagnostic Laboratory (AHDL) is responsible for monitoring the health of all rodents at NCI-Frederick, NCI-Bethesda, NCI-DTP Rodent Producers, and several NCI contract facilities. The AHDL also provides diagnostic resources to several other NIH facilities and USAMRIID. The major focus of the diagnostic services includes microbiology, parasitology, serology, and health-monitoring necropsies. The AHDL has been a consistent resource to the scientific community for more than 30 years. BTB Animal Care Support - SAIC-Frederick, Inc., and NCI Bethesda are among the 730 organizations, institutions, and companies worldwide that are accredited by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). The animal support areas of LASP consist of the Animal Health Diagnostic Laboratory (AHDL), Animal Molecular Diagnostic Laboratory (AMDL), Receiving and Quarantine (R&Q), Laboratory Animal Medicine (LAM), and NCI animal facilities. The Laboratory Animal Sciences Program provides animal care support to the BTB in vivo preclinical testing effort as well as the PK studies group. This includes direct animal care at the individual cage level as well as support for cage washing and autoclaving as well as maintaining facility supplies of animal care related materials.

BTB支持 - 生物测试分支支持小组负责提供与发育疗法计划确定的新抗癌剂的临床前化学和药理学有关的信息。对生物液中候选药物的分析涉及为每个候选药物创建，应用和验证方法。然后，这种分析方法允许研究剂量，生物流体（例如血浆或尿液）浓度和生物效应之间可能存在的相互关系。此类研究的结果可能会导致对药物活性的更好理解，并提出最佳的途径和剂量时间表。这样的努力需要广泛了解高性能液相色谱（HPLC），气相色谱法（GC）和分子光谱法，例如紫外线（UV），荧光以及所有形式的质谱法。此外，该组还负责为最近实施的NCI发起的0期临床试验提供药理支持。除了这项工作支持的科学研究外，该小组还负责为DCTD动物生产计划提供行政支持。该计划将啮齿动物提供给NCI，NIH，USAMRIID，FDA和其他政府机构。此外，还以可提供的基础向NIH授予者提供了剩余的动物。这项工作支持开发用于治疗癌症，艾滋病毒和其他病毒疾病的药物所需的许多临床前研究，细菌和毒素诱导的疾病，包括糖尿病在内的代谢疾病，包括自身免疫性疾病在内的免疫诱发疾病以及联邦研究基金支持的其他疾病国家。 DTP动物QC-人类疾病的动物模型在我们对疾病进展和治疗的理解中继续发挥关键作用。作为对各种动物模型研究的支持的一部分，DCTD拥有动物生产合同，可为NCI，NIH，FDA，USAMRIID，其他联邦机构以及NIH授予者提供啮齿动物生产合同。作为这项工作的一部分，DCTD通常评估分发动物的健康状况，以确保研究社区获得所接受的研究动物的质量和生物安全性。为此，实验室动物科学计划（LASP）为动物生产殖民地健康状况的常规和特殊评估提供了诊断服务。这些测定包括鼠抗体的产生（MAP）测试，这些测试鉴定了隐匿性病毒感染，基于PCR的螺旋杆菌和某些病毒剂的测定法，以及对啮齿动物和富米特衍生样品的细菌学评估，以确保生产菌落的状态。此外，该实验室可以监视NCI-Frederick的所有啮齿动物菌落的健康，该菌落通过识别和消除弗雷德里克校园内可能的感染来源来进一步保护DCTD动物生产计划。 动物健康诊断实验室（AHDL） - 动物健康诊断实验室（AHDL）负责监测NCI-Frederick，NCI-Bethesda，NCI-DTP啮齿动物生产商和几个NCI合同的所有啮齿动物的健康。 AHDL还向其他几个NIH设施和USAMRIID提供诊断资源。诊断服务的主要重点包括微生物学，寄生虫学，血清学和健康监测死灵。 30多年来，AHDL一直是科学界的一致资源。 BTB动物护理支持-Saic -Frederick，Inc。和NCI Bethesda是全球的730个组织，机构和公司之一，这些组织，机构和公司是由实验室动物护理国际（AAAALAC International）评估和认证协会认可的。 LASP的动物支持区域包括动物健康诊断实验室（AHDL），动物分子诊断实验室（AMDL），接收和隔离（R＆Q），实验室动物医学（LAM）和NCI动物设施。实验室动物科学计划为BTB在体内临床前测试工作以及PK研究小组提供动物护理支持。这包括在各个笼子水平上的直接动物护理，以及对清洗和高压灭菌的支持以及维护与动物护理相关材料的设施供应。