TAS::75 0872::TAS GENTAC (8470187)

塔斯::75 0872::塔斯 GENTAC (8470187)

• 批准号: 8165783
• 负责人: BARBARA L KRONER
• 金额: $ 404.36万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2015-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8165783
• 关键词: Affect; Cardiovascular system; Cessation of life; Clinical Management; Clinical Research; Collection; Communities; Data; Data Quality; Data Set; Databases; Diagnosis; Echocardiography; Enrollment; Ensure; Genetic; Goals; Image; Knowledge; Magnetic Resonance Imaging; Morbidity - disease rate; Pathology; Patients; Persons; Phenotype; Registries; Research; Research Design; Resources; Sample Size; Subgroup; Thoracic Aortic Aneurysm; base; comparative effectiveness; improved; interest; premature; prospective; repository; treatment strategy

The goal of the renewal is to continue and expand the data and biospecimen collection of patients with genetically triggered TAAs. The overriding purpose of the GenTAC Registry is to establish a robust data bank and biospecimen repository, and facilitate fundamental and clinical research through use of these resources. The ultimate goal is to reduce cardiovascular complications, which represent the primary cause of morbidity and premature death in persons with genetically triggered thoracic aortic aneurysms. The Registry is a critical resource that can be used by the research community to further understand and study the genetic basis of TAAs and to improve the diagnosis and clinical management of affected patients.

更新的目标是继续和扩大数据和生物标本的收集， 遗传性TAA患者GenTAC注册中心的首要目的是 建立健全数据库和生物标本库，促进基础和临床 通过使用这些资源进行研究。最终目的是减少心血管 并发症，这是发病和过早死亡的主要原因， 遗传性胸主动脉瘤注册表是一项重要资源， 被研究界用来进一步了解和研究TAAs的遗传基础 并改善对受影响患者的诊断和临床管理。