TAS::75 0849::TAS MULTIFUNCTIONAL NANODEVICE FOR TARGETED CANCER MR IMAGING AND

TAS::75 0849::TAS 用于靶向癌症 MR 成像的多功能纳米设备

• 批准号: 8165882
• 负责人: Zhiguo Zhou
• 金额: $ 20万
• 依托单位: LUNA INNOVATIONS, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-24 至 2011-06-23
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8165882
• 关键词: Adverse effects; Animals; Antineoplastic Agents; Cancer Cell Growth; Cancerous; Cell Culture Techniques; Cells; Diagnosis; Diagnostic; Drug Controls; Foundations; Growth; Image; In Vitro; Magnetic Resonance Imaging; Malignant Neoplasms; Micelles; Monitor; Outcome; Patients; Pharmaceutical Preparations; Phase; Site; Testing; Therapeutic; Therapeutic Index; design; drug efficacy; improved; in vivo; innovation; nanodevice; premature; prevent; research and development; research study; targeted delivery; tumor

Multifunctional theranostic nanodevices carrying therapeutic payloads, diagnostic agents, and targeted and controlled drug release functions can simultaneously and effectively diagnose and treat cancers. The targeted delivery of chemotherapeutics to tumors can significantly increase the efficacy of drugs while minimizing the severe side effects associated with the drug itself. The integration of the four functions into one single platform holds great promise for increasing therapeutic index and improving patient outcome. The proposed theranostic nanodevice by Luna Innovations will be tested in both cell culture experiments and in vivo small animal studies during the Phase I period. Each component of the integrated nanodevice has been designed to carry its specific function of loading anticancer drugs, preventing the drug from premature release, triggering drug release when it reaches its intended region of action, guiding the nanodevice to tumor sites, inhibiting the growth of cancerous cells, or monitoring the tumor regression by MR imaging. Luna anticipates that both of the in vitro and in vivo results will validate the design of the multifunctional nanodevice and demonstrate the feasibility of the nanodevice for simultaneous diagnosis and treatment of tumors. These results will provide a foundation for full R&D efforts in Phase II.

携带治疗有效载荷、诊断试剂以及靶向和受控药物释放功能的多功能治疗纳米设备可以同时有效地诊断和治疗癌症。这个 靶向向肿瘤输送化疗药物可以显著提高药物的疗效，同时将与药物本身相关的严重副作用降至最低。将四大职能整合为 一个单一的平台在增加治疗指数和改善患者预后方面有着巨大的希望。露娜创新公司提出的声学纳米器件将在细胞培养实验和 第一阶段期间的体内小动物研究。集成纳米设备的每个组件都被设计成携带其特定的功能，即装载抗癌药物，防止药物过早上市 这些技术包括药物释放、达到预期作用区域时触发药物释放、将纳米设备引导至肿瘤部位、抑制癌细胞生长或通过核磁共振成像监测肿瘤消退。露娜预计，体外和体内的结果都将验证多功能纳米设备的设计，并证明该纳米设备同时用于肿瘤诊断和治疗的可行性。这些成果将为第二阶段的全面研发工作奠定基础。