Nanoparticle scavengers for medical countermeasures against mycotoxin

用于霉菌毒素医疗对策的纳米颗粒清除剂

• 批准号: 8524115
• 负责人: Zhiguo Zhou
• 金额: $ 23.49万
• 依托单位: LUNA INNOVATIONS, INC.
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8524115
• 关键词: Acute; Affinity; Air; Antidotes; Area; Attenuated; Behavioral; Binding; Biochemical; Biological Assay; Bioterrorism; Blood Circulation; Body Fluids; Carcinogens; Chemistry; Chronic; Clinical; Development; Dissociation; Dose; Drug Formulations; Drug Kinetics; Drug toxicity; Emergency Situation; Event; Excretory function; Exposure to; Extravasation; Fat emulsion; Food; Future; Goals; Government; Health; Immunotoxins; In Vitro; Incidence; Injection of therapeutic agent; Investigational Drugs; Investigational New Drug Application; Life; Link; Medical; Military Personnel; Molecular; Mycotoxins; Nanotechnology; Neurotoxins; Organism; Overdose; Particle Size; Persons; Pharmaceutical Preparations; Phase; Physiological; Poisoning; Preparation; Process; Property; Protocols documentation; Public Health; Quality Control; Rattus; Readiness; Rodent; Safety; Surface; Technology; Therapeutic; Toxic effect; Toxin; Translations; Water; base; biocompatible polymer; chemical stability; clinical application; clinically relevant; crosslink; cytotoxicity; empowered; fungus; hepatotoxin; immunogenic; improved; in vivo; innovation; interest; meetings; nanoparticle; nanoscale; particle; preclinical study; prevent; programs; prophylactic; public health relevance; response; small molecule; sterility testing; success; therapeutic effectiveness; tool

DESCRIPTION (provided by applicant): Mycotoxin is naturally occurring and is a toxic small molecule produced by fungi. These fungal toxins are representative of a large number of lipophilic agents that pose significant acute and chronic dangers to military combatants as potential warfare agents. There are many examples of mycotoxins, some more acutely potent than others. Mycotoxin is classified as hepatotoxins, nephrotoxins, neurotoxins, immunotoxins, and carcinogens. Mycotoxin could also be a threat to the public health due to food, water or air contamination. Currently, there are no treatments for mycotoxin exposure in either the acute or chronic setting, and the lack of an effective therapeutic could be catastrophic. In order to protec the safety and health of military personnel and civilians, there is a need to develop a therapeutic and prophylactic drug, which can effectively reduce concentrations below its toxic level and minimize the incidence of clinical toxicity. Luna proposes to develop nanoparticle scavengers that can efficiently sequester the lipophilic mycotoxins in vivo and facilitate their clearance. Ths nanotechnology-based approach offers the potential to treat people under suspicion of actual or potential mycotoxin poisoning. Phase I efforts will focus on demonstrating proof-of-concept in vivo efficacy at attenuating mycotoxin-induced acute toxicities, and demonstrating the safe use of Luna's nanoparticles in one rodent species. Phase II efforts will focus on IND-enabling preclinical studies. Success of the program will provide a valuable medical countermeasure tool against mycotoxins, and it may also find clinical applications for other lipophilic toxins or for overdosed drug toxicities. The nanoparticle antidotes could be important for the Strategic National Stockpile in preparing for an emergency involving bioterrorism. Thus, this proposed technology is of great interest to the public health, and also enhances the nation's preparedness against potential mycotoxin attacks.

描述（由申请人提供）：真菌毒素是自然产生的，是一种由真菌产生的有毒小分子。这些真菌毒素是大量亲脂剂的代表，它们作为潜在的战争剂对军事战斗人员构成严重的急性和慢性危险。真菌毒素的例子很多，有些比其他的更强烈。真菌毒素分为肝毒素、肾毒素、神经毒素、免疫毒素和致癌物。由于食物、水或空气污染，霉菌毒素也可能对公众健康构成威胁。目前，无论是急性还是慢性真菌毒素暴露都没有治疗方法，缺乏有效的治疗方法可能是灾难性的。为了保护军事人员和平民的安全和健康，有必要开发一种治疗方法