Nanoparticle scavengers for in vivo sequestration of overdosed drug molecules

用于体内隔离过量药物分子的纳米颗粒清除剂

基本信息

  • 批准号:
    8524099
  • 负责人:
  • 金额:
    $ 12.84万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2013
  • 资助国家:
    美国
  • 起止时间:
    2013-08-01 至 2016-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Drug toxicity due to either overdose or abusive use represents a major healthcare problem. According to the Toxic Exposure Surveillance System data pharmaceuticals are implicated in 42% of all poisoning cases with >123,000 annual cases caused by therapeutic errors. The National Center for Health Statistics report that 22,000 people died of drug overdose in the U.S. in 2005 alone, and the number is growing rapidly. General rescue therapies such as cardiopulmonary resuscitation, intravenous catecholamines to support homeostasis are used to treat drug intoxications in emergency room. These supportive therapies work to some extent; but there is a clearly unmet need for alternative emergency medicine that can effectively and rapidly lower the toxic concentrations of overdosed drugs. In particular, accidental overdose of bupivacaine, a local anesthetic has been reported to cause many cases of cardiac arrest and death. Intralipid is the only therapeutic scavenger with demonstrated clinical success in attenuating toxicities induced by overdosed lipophilic drugs. However improvements are needed to enhance the sequestration efficiency, reduce the dosing volume, and shorten the treatment period. Luna proposes to develop core-shell therapeutic nanoparticles that are capable of extracting lipophilic molecules from body fluids to its lipophili core, and thus overdosed drug is sequestered and its effective concentration is lowered. We hypothesized that the significantly enhanced surface area to volume ratio of Luna's nanoparticles relative to Intralipid will dramatically improve the sequestration efficiency, so tha drug toxicities can be ameliorated more effectively and rapidly. Luna's nanoparticle scavenger has the potential for a successful clinical translation as an antidote to overdosed drugs. Success of such a therapeutic product would be a valuable addition to the existing clinical armamentarium in emergency room.
描述(由申请人提供):由于过量或滥用导致的药物毒性是一个主要的医疗保健问题。根据有毒物质接触监测系统的数据,42%的中毒病例与药物有关,每年有超过123,000例病例是由治疗错误引起的。国家卫生统计中心报告说,仅在2005年,美国就有22,000人死于药物过量,而且这个数字还在迅速增长。一般的抢救治疗,如心肺复苏,静脉注射儿茶酚胺,以支持体内平衡,用于治疗药物中毒在急诊室。这些支持疗法在一定程度上起作用;但对替代急诊医学的需求显然没有得到满足,这种替代急诊医学可以有效和快速地降低过量药物的毒性浓度。特别是,意外过量的布比卡因,一种局部麻醉剂已被报道导致许多心脏骤停和死亡的病例。Intraperoid是唯一的治疗性清除剂,在减轻过量亲脂性药物诱导的毒性方面取得了临床成功。然而,需要改进以提高封存效率,减少投加体积,并缩短处理周期。Luna提出开发核-壳治疗性纳米颗粒,其能够从体液中提取亲脂性分子到其亲脂性核心,从而隔离过量的药物并降低其有效浓度。我们假设,Luna纳米颗粒相对于Intraperoid的显著增加的表面积与体积比将显著提高螯合效率,从而可以更有效和更快速地改善药物毒性。Luna的纳米颗粒清除剂具有成功的临床转化潜力,可作为过量药物的解毒剂。这种治疗产品的成功将是对急诊室现有临床设备的有价值的补充。

项目成果

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Zhiguo Zhou其他文献

Zhiguo Zhou的其他文献

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{{ truncateString('Zhiguo Zhou', 18)}}的其他基金

Fullerene-based Radioprotectors for Use during Brain Radiotherapy, Period of Performance 09/15/2014 - 05/15/2015
用于脑部放射治疗期间使用的富勒烯放射防护剂,执行期间 09/15/2014 - 05/15/2015
  • 批准号:
    8948732
  • 财政年份:
    2014
  • 资助金额:
    $ 12.84万
  • 项目类别:
Developing New Assessment Tools for Carbon Nanomaterial-Based Contaminants
开发基于碳纳米材料的污染物的新评估工具
  • 批准号:
    8714259
  • 财政年份:
    2014
  • 资助金额:
    $ 12.84万
  • 项目类别:
Improved Metallofullerene MRI Contrast Agent for Cancer Diagnosis
用于癌症诊断的改进金属富勒烯 MRI 造影剂
  • 批准号:
    8686795
  • 财政年份:
    2013
  • 资助金额:
    $ 12.84万
  • 项目类别:
Nanoparticle scavengers for medical countermeasures against mycotoxin
用于霉菌毒素医疗对策的纳米颗粒清除剂
  • 批准号:
    8524115
  • 财政年份:
    2013
  • 资助金额:
    $ 12.84万
  • 项目类别:
Enhanced bioscavenger for medical countermeasures against organophosphorus agents
用于针对有机磷制剂的医疗对策的增强型生物清除剂
  • 批准号:
    8524618
  • 财政年份:
    2013
  • 资助金额:
    $ 12.84万
  • 项目类别:
Improved Metallofullerene MRI Contrast Agent for Cancer Diagnosis
用于癌症诊断的改进金属富勒烯 MRI 造影剂
  • 批准号:
    8507969
  • 财政年份:
    2013
  • 资助金额:
    $ 12.84万
  • 项目类别:
TAS::75 0849::TAS MULTIFUNCTIONAL NANODEVICE FOR TARGETED CANCER MR IMAGING AND
TAS::75 0849::TAS 用于靶向癌症 MR 成像的多功能纳米设备
  • 批准号:
    8165882
  • 财政年份:
    2010
  • 资助金额:
    $ 12.84万
  • 项目类别:

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