FaceBase 2 Coordinating Center

描述(由申请人提供)：FaceBase联盟是一个研究头面部发育和畸形的研究人员的分布式网络。该联盟包括通过资助的“辐条”项目直接参与的研究项目，以及整个颅面研究社区的成员。收集、共享和集成来自人类和动物模型的异质数据，包括遗传、成像和解剖学数据，对于推进颅面研究是至关重要的。我们将开发和维护FaceBase 2数据管理和集成中心基础设施，该基础设施将适当地存储、表示这些数据并为研究社区提供服务，此外还提供可视化、集成、注释、链接和分析数据的工具。我们的三大目标不仅将提供所需的数据迁移和管理，还将提供一套以用户为中心的数据可视化、比较和注释工具。它们是：目标1：创建由易用性和以用户为中心的设计原则驱动的基础设施，以在数据的整个生命周期中管理数据。通过采取以用户为中心的方法并支持在数据的整个生命周期中使用数据，可以最大限度地提高集线器的发现速度和利用率。目标2：在中心内提供工具，通过启用数据注释、集成和分析来加速颅面研究。为了最大限度地发挥中心对分支项目和外部用户的效用，我们提议的基础设施将允许任何用户定义个人工作空间，将数据集可视化工具和分析工具组织到特定的用户驱动的工作流程中。目标3：促进整个FaceBase研究网络的使用和协作。该中心将向财团提供广泛的协作工具和服务，并组织面对面的会议，以加强协作。我们组建了一支经验丰富的生物信息学、成像、遗传学、小鼠和人体研究专家团队，其中包括FaceBase参与者，他们将头面部研究社区的需求带来了第一手知识。FaceBase团队特意多样化，为每个分支小组提供至少一名知情联系人，他们将在中心的开发和实施中发挥不可或缺的作用，从而确保每个分支项目的数据将对研究人员社区产生最大影响。

DESCRIPTION (provided by applicant): The FaceBase consortium is a distributed network of researchers investigating craniofacial development and dysmorphology. The consortium includes research projects directly participating via funded "spoke" projects as well as members of the craniofacial research community at large. The collection, sharing and integration of heterogeneous data, including genetic, imaging, and anatomical, from human and animal models are essential for advancing craniofacial research. We will develop and maintain a FaceBase 2 Data Management and Integration Hub infrastructure that will properly store, represent, and serve these data to the research community, and in addition provide access to tools for visualizing, integrating, annotating, linking and analyzing the data. Our three broad aims will provide not only the needed data migration and management, but also a set of user-centered tools for data visualization, comparison and annotation. These are: Aim 1: Create an infrastructure driven by principles of ease of use and user centered design to manage data throughout its lifecycle. By taking a user centric approach and supporting the use of data throughout its lifecycle, the rate of discovery and utility of the hub can be maximized. Aim 2: Provide tools within the Hub that accelerate craniofacial research by enabling data annotation, integration and analysis. To maximize the utility of the Hub for both spoke projects and outside users, our proposed infrastructure will allow any user to define a personal workspace, organize datasets visualization tools and analysis tools into specific user-driven workflows. Aim 3: Promote use and collaboration across the FaceBase research network. The Hub will provide a wide range of collaboration tools and services to the consortium as well as organizing face-to-face meetings in order to enhance collaboration. We have assembled an experienced team of experts in bioinformatics, imaging, genetics, mouse and human studies, including FaceBase participants who bring firsthand knowledge of the needs within the craniofacial research community. The FaceBase team is intentionally diverse, to provide each spoke group at least one informed contact who will play an integral role in the development and implementation of the Hub, thereby ensuring that the data of each spoke project will have maximum impact on the community of researchers.