USC GUDMAP Coordinating Center

项目摘要 肾脏和泌尿道的先天性异常是常见的出生缺陷。这些缺陷是一个重大的 影响美国人的公共卫生问题，可能未被发现，但会增加慢性疾病的风险。 生活中的疾病自成立以来，生殖泌尿发育分子解剖学项目 （GUDMAP）已经为广泛的表达数据提供了框架和储存库，以提供分子生物学方法。 小鼠泌尿生殖系统发育的解剖学，长期目标是利用和分享我们的 泌尿生殖系统发育的知识，以打造创新的新方法来治疗疾病。这项工作 推进了我们对发育中的肾单位、下泌尿系统和其他组织中的亚群和模式化事件的理解。 生殖道和生殖腺。对肾脏形成的分子驱动因素的深入了解有助于告知当前的 在该领域的努力，以创造肾脏类器官的治疗和疾病的研究。 我们建议运行一个GUDMAP数据库，该数据库将促进协调、重点突出、适应性强和 由几个小组进行的交互式研究计划，比静态的独立研究计划更快地产生结果。 研究项目。跨研究联盟的协调要求能够快速整合新的 研究项目，交流成果，并在整个联盟中共享知识和数据。我们的工作将 在小鼠和人类数据之间建立联系，将功能与疾病联系起来， 病因和治疗靶点。通过提供工具来合并和链接不同的数据集，我们将提供 有效和简单的方法来提出问题和进一步的研究。GUDMAP数据库将进行Meta- 分析，以产生信息的方式使用我们建立的工具，并提出新的可检验的假设 关于泌尿生殖系统发育和疾病。 我们提出的生殖泌尿发育分子解剖学项目（GUDMAP）数据库将：1）创建 组织结构和流程，以实现无缝和频繁的沟通， GUDMAP研究人员与国家糖尿病、消化和肾脏研究所合作， 疾病（NIDDK）和更广泛的研究社区; 2）创建一个高度可用的数据库， 改变研究人员的集合，以快速上传，组织和搜索异构数据类型; 3）构建 一个全面的工具包，用于数据注释、管理、分析、可视化和交叉验证; 4）拓宽 研究界，并通过建立一个有针对性的短期研究成果框架， 机会库计划; 5）向更广泛的研究界传播联盟资源。总的来说， GUDMAP的这些要素的影响将加快联合体内部的发现速度， 更广泛的社区。

Project Summary Congenital anomalies of the kidney and urinary tract are common birth defects. These defects are a significant public health problem affecting Americans and further, may go undetected but increase the risk of chronic diseases later in life. Since its inception, the GenitoUrinary Development Molecular Anatomy Project (GUDMAP) has provided a framework and repository for extensive expression data to provide a molecular anatomy of genitourinary development in the mouse with the long-term goal to harness and share our knowledge of urogenital development to forge innovative new approaches to treat disease. This work has advanced our understanding of subpopulations and patterning events in the developing nephron, lower urinary tract, and gonads. A deep understanding of the molecular drivers of kidney formation serves to inform current efforts in the field to create kidney organoids for therapeutic and disease studies. We propose to operate a GUDMAP Database that will facilitate a coordinated, focused, adaptive and interactive program of research by several groups, yielding results faster than a static collection of independent research projects. Coordination across the research consortium demands the ability to rapidly integrate new research projects, communicate results, and share knowledge and data across the consortium. Our work will generate connections between mouse and human data to link function to disease and thus identify potential causal and therapeutic targets. By providing tools to coalesce and link disparate datasets, we will provide efficient and easy methods to pose questions and further research. The GUDMAP Database will conduct meta- analysis to produce both informative ways to use the tools we build, and propose new testable hypotheses regarding urogenital development and disease. Our proposed GenitoUrinary Development Molecular Anatomy Project (GUDMAP) Database that will: 1) create organizational structure and processes that will enable seamless and frequent communication and collaboration between GUDMAP researchers, the National Institute for Diabetes and Digestive and Kidney Diseases (NIDDK) and the broader research community; 2) create a highly usable database that will empower changing collections of researchers to rapidly upload, organize, and search heterogeneous data types; 3) build a comprehensive toolkit for data annotation, curation, analysis, visualization, and cross validation; 4) broaden the research community and create a framework for targeted shorter term research results by establishing an opportunity pool program; 5) disseminate consortium resources to the wider research community. In total, the impact of these elements of the GUDMAP will accelerate the rate of discovery within the consortium and the broader community.