The USC (Re)Building the Kidney Coordinating Center

南加州大学（重建）肾脏协调中心

• 批准号: 9146890
• 负责人: Carl Kesselman
• 金额: $ 125.29万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-23 至 2020-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9146890
• 关键词: Acute; Address; Award; Biological Models; Birth; Blood Vessels; Cell physiology; Chronic; Collaborations; Collection; Communication; Communication Tools; Communities; Complement; Complex; Coordination and Collaboration; Data; Data Coordinating Center; Development; Diagnosis; Dialysis procedure; Education and Outreach; Elements; Ensure; Epithelial; FaceBase; Feedback; Feeds; Genomics; Goals; Health; Image; Individual; Injury; Institutes; International; Internet; Interview; Kidney; Kidney Diseases; Kidney Transplantation; Knowledge; Leadership; Life; Methods; Molecular; Monitor; National Institute of Diabetes and Digestive and Kidney Diseases; Nephrons; Organ; Patients; Pattern; Play; Policies; Population; Procedures; Process; Publications; Publishing; Renal function; Renal tubule structure; Research; Research Infrastructure; Research Personnel; Research Project Grants; Secure; Security; Staging; Structure; Suggestion; Surveys; Survival Rate; Teleconferences; Time; Transplantation; Work; data access; data portal; data sharing; design; empowered; experience; fetal; forging; human data; innovation; kidney repair; meetings; member; nephrogenesis; novel strategies; operation; organizational structure; progenitor; programs; repaired; restoration; stem; tool; user centered design; web site; working group

 DESCRIPTION (provided by applicant): The functional unit of the mammalian kidney is the nephron - a complex, composite structure comprising an epithelial renal tubule with a closely associated specialized vascular network. Nephrons arise from a nephrogenic stem/progenitor population that only exists during fetal life. Consequently, the entire complement of nephrons is formed prior to birth. Thereafter, restoration of existing nephron structures is the organ's intrinic strategy for kidney repair following acute, and likely chronic, injury episodes. From studies in non-human model systems, we have a general framework for the molecular and cellular processes at play during kidney development and an understanding is emerging of intrinsic repair processes that maintain normal kidney function. Unfortunately, normal repair processes are inadequate: 1,000,000 patients are currently diagnosed with end state renal disease (ESRD), approximately 400,000 of these are on dialysis with a mean 5-year survival rates of 38%. The only option beyond dialysis for the ESRD patient is kidney transplant, but the number of transplants - approximately 20,000/year - does not match patient need. The long-term goal of the (Re)Building the Kidney Consortium is to harness our knowledge of nephron development and repair to forge innovative new approaches to treat injury and disease of the kidney. The consortium is being developed with the underlying thesis that a coordinated, focused, adaptive and interactive program of research by several groups has the potential to yield results in a timeframe that would not be possible through a static collection of independent single investigator sponsored research projects. Coordination across the research consortium demands the ability to rapidly integrate new research projects, communicate results, and share knowledge and data across the consortium. It is not enough to publish results at the end of a study, but rather, it must be possible to incrementally share at all stages of the research process. To address these issues, we propose to create a ReBuilding the Kidney Coordinating Center (RBKC) to ensure the consortium operates effectively as a coordinated research network, maximizing the value of individual projects, and communicates consortium activities to the broad research community. Specifically, the RBKC aims to: 1) create organizational structure and processes that will enable seamless and frequent communication and collaboration between RBKC researchers, the NIDDK and the broader research community, 2) create a data portal that will empower changing collections of researchers to rapidly create, analyze, share and discover diverse types of data, 3) broaden the research community and create a framework for targeted shorter term research results by establishing and managing an opportunity pool program, 4) disseminate consortium results to the broader research community. In total, the impact of these elements of the RBKC will accelerate the rate of discovery within the consortium and by the broader community.

 描述（由申请人提供）：哺乳动物肾脏的功能单位是肾单位-一种复杂的复合结构，包括上皮肾小管和密切相关的特化血管网。肾单位产生于仅存在于胎儿生命期间的生肾干/祖细胞群。因此，肾单位的整个补充在出生前形成。此后，现有肾单位结构的恢复是器官在急性和可能的慢性损伤事件后用于肾修复的内在策略。从非人类模型系统的研究中，我们对肾脏发育过程中起作用的分子和细胞过程有了一个总体框架，并且对维持正常肾功能的内在修复过程有了新的理解。不幸的是，正常的修复过程是不够的：目前有1，000，000名患者被诊断患有终末期肾病（ESRD），其中约400，000人正在接受透析，平均5年生存率为38%。ESRD患者除透析外的唯一选择是肾移植，但移植数量（约20，000/年）与患者需求不符。（重新）建立肾脏联盟的长期目标是利用我们对肾单位发育和修复的知识，打造治疗肾脏损伤和疾病的创新方法。该联盟正在发展的基本论点是，一个协调的，有重点的，自适应的和互动的研究计划，由几个团体有可能产生的结果，在一个时间框架内，这将是不可能通过一个独立的单一研究者赞助的研究项目的静态集合。跨研究联盟的协调需要能够快速整合新的研究项目，交流结果，并在联盟中共享知识和数据。仅仅在研究结束时公布结果是不够的，还必须能够在研究过程的各个阶段逐步分享。为了解决这些问题，我们建议建立一个重建肾脏协调中心（RBKC），以确保联盟作为一个协调的研究网络有效运作，最大限度地提高单个项目的价值，并将联盟活动传达给广大的研究界。具体而言，喀堪皇家银行的目标是：1）创建组织结构和流程，使RBKC研究人员，NIDDK和更广泛的研究社区之间能够进行无缝和频繁的沟通和协作，2）创建数据门户，使不断变化的研究人员能够快速创建，分析，共享和发现各种类型的数据，3）通过建立和管理机会池计划，扩大研究社区并为有针对性的短期研究成果创建框架，4）将联盟成果传播给更广泛的研究社区。总的来说，RBKC的这些元素的影响将加快联盟内部和更广泛社区的发现速度。